Results 41 to 50 of about 3,453,209 (234)

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

CA9‐Targeted PET Imaging for Noninvasive Discrimination of Clear Cell Renal Cell Carcinoma and Associated Tumor Biological Features

Advanced Science, EarlyView.
CA9‐targeted PET imaging could be a noninvasive approach to characterize clear cell renal cell carcinoma and associated tumor biology. PET uptake correlates with tumor CA9 expression and is linked to angiogenic activity, immune remodeling, and metabolic reprogramming.
Kailei Chen, Sixuan Cheng, Jian Shi, Ruijie Liu, Yilong Wu, Xin Zheng, Xinlun Song, Yunxuan Zhang, Lei Liu, Zhihao Wei, Qi Wang, Xinwei Li, Zirui Dong, Yuenan Liu, Hongmei Yang, Xiaoli Lan, Chunxia Qin, Dawei Jiang, Keshan Wang, Xiaoping Zhang   +19 more
wiley   +1 more source

CLRe: A Synergistic Dual‐Engine Framework for One‐Step Retrosynthesis Prediction

Advanced Science, EarlyView.
CLRe uses a contrastive difficulty score to order pretrained seq2seq fine‐tuning for retrosynthesis. Reaction embeddings define the ranking score, and a cumulative easy‐to‐hard schedule expands from the easiest subset to the full training set while earlier examples remain active.
Tianhao Su, Xitao Wang, Musen Li, Guanhua Qin, Shunbo Hu, Tong‐Yi Zhang   +5 more
wiley   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Rethinking the Roles of Large Language Models in Chinese Grammatical Error Correction

Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics (Volume 6: Industry Track)
Recently, Large Language Models (LLMs) have been widely studied by researchers for their roles in various downstream NLP tasks. As a fundamental task in the NLP field, Chinese Grammatical Error Correction (CGEC) aims to correct all potential grammatical errors in the input sentences.
Yinghui Li, Shang Qin, Jingheng Ye, Haojing Huang 0001, Yangning Li, Shu-Yu Guo, Libo Qin 0001, Xuming Hu, Wenhao Jiang, Hai-Tao Zheng 0002, Philip S. Yu   +10 more
openaire   +3 more sources

Human Evaluation of Grammatical Error Correction Systems [PDF]

, 2015
The paper presents the results of the first large-scale human evaluation of automatic grammatical error correction (GEC) systems. Twelve participating systems and the unchanged input of the CoNLL-2014 shared task have been reassessed in a WMT-inspired ...
Junczys-Dowmunt, Marcin, Grundkiewicz, Roman, Roman Grundkiewicz, Gillian, Edward, Edward Gillian, Marcin Junczys-Dowmunt   +5 more
core   +3 more sources

Mining Error Templates for Grammatical Error Correction

, 2022
Some grammatical error correction (GEC) systems incorporate hand-crafted rules and achieve positive results. However, manually defining rules is time-consuming and laborious.
Jiang, Haochen, Li, Chen, Bao, Zuyi, Zhang, Yue, Li, Zhenghua, Zhang, Bo   +5 more
core  

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

EXCGEC: A Benchmark for Edit-Wise Explainable Chinese Grammatical Error Correction

Proceedings of the AAAI Conference on Artificial Intelligence
Existing studies explore the explainability of Grammatical Error Correction (GEC) in a limited scenario, where they ignore the interaction between corrections and explanations and have not established a corresponding comprehensive benchmark. To bridge the gap, this paper first introduces the task of EXplainable GEC (EXGEC), which focuses on the ...
Jingheng Ye, Shang Qin, Yinghui Li, Xuxin Cheng, Libo Qin 0001, Hai-Tao Zheng 0002, Ying Shen 0001, Peng Xing, Zishan Xu, Guo Cheng, Wenhao Jiang   +10 more
openaire   +3 more sources