Results 31 to 40 of about 480,461 (318)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Speech emotion analysis using convolutional neural network (CNN) and gamma classifier-based error correcting output codes (ECOC)

Scientific Reports, 2023
Speech emotion analysis is one of the most basic requirements for the evolution of Artificial Intelligence (AI) in the field of human–machine interaction. Accurate emotion recognition in speech can be effective in applications such as online support, lie
Yunhao Zhao, Xiaoqing Shu
doaj   +1 more source

Zhao Yizhen and the Thunder Method Inherited from His Master Zhang Tianquan

Religions, 2023
Zhao Yizhen (?–1382) was one of the most important figures in the history of Daoism in the Yuan and Ming Dynasties. His master, Zhang Tianquan (1275–?), was recorded to be a disciple of Jin Pengtou (?–1341), a famous master of inner alchemy in the late ...
Wei Xu
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Comparative study of Danshen and Siwu decoction based on the molecular structures of the components and predicted targets

BMC Complementary Medicine and Therapies, 2021
Background The sentence of “Danshen (Salvia Miltiorrhizae Radix et Rhizoma) and Siwu decoction are similar in function” was first recorded in an ancient Chinese medical book “Fu Ren Ming Li Lun”.
Yang Li, Li Qiao, Cong Chen, Zhenguo Wang, Xianjun Fu   +4 more
doaj   +1 more source

When Paper Puppy Meets Beijing Doll: Reading Adolescent Female Sexuality in Two Chinese Youth Novels

International Journal of Young Adult Literature, 2022
Known for their frank portrayals of female sexuality, Paper Puppy (2019) by Yin Jianling and Beijing Doll (2004) by Chun Sue and are often considered among the landmark works of Chinese adolescent literature.
Yan Du
doaj   +1 more source

Chinese Literature

Procedia - Social and Behavioral Sciences, 2010
Emperor and General: Some Comments on the Formal and Thematic Continuities between the Vernacular Stories from Dunhuang and the Vernacular Stories from Later ...
openaire   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Sacred islands and island symbolism in Ancient and Imperial China: an exercise in decolonial island studies

Island Studies Journal, 2017
This paper explores conceptions of islands in Ancient and Imperial China. From at least the 3rd Century BCE, mainland Chinese culture regarded islands as sacred, unapproachable fairylands, home to the elixir of immortality.
Bin Luo, Adam Grydehøj
doaj   +1 more source