Results 51 to 60 of about 23,706 (312)

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis

Advanced Science, EarlyView.
A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Ziqi Liang, Xitong Song, Shuming Cheng, Yiwen Shen, Jie Zhang, Yaru Wang, Huiying Luo, Bin Yao, Binju Wang, Tao Tu   +9 more
wiley   +1 more source

Cascade‐Responsive MXene@Cu‐MOF Heterostructure Integrates Antioxidant Activity, Infection Control, and Vascularization for Tracheal Repair

Advanced Science, EarlyView.
A cascade‐responsive MXene@Cu‐MOF/GelMA hydrogel is engineered as a “skeleton–backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu‐MOF component provides pH/NIR‐responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis.
Liang Guo, Yingran Shen, Jiaoyu Yi, Juanjuan Li, Ziming Wang, Erji Gao, Siqiang Zheng, Zhe‐Sheng Chen, Bo Tao   +8 more
wiley   +1 more source

A TtAgo‐Driven Autocatalytic Circuit with Thermal‐Enhanced Kinetics for One‐Pot Nucleic Acid Detection

Advanced Science, EarlyView.
This study proposes a universal catalytic DNA circuits termed TACTIC (Thermus thermophilus protein‐driven autocatalytic circuit) for one‐pot detection of DNA and RNA in multiple clinical samples. Integrated with machine learning, TACTIC accurately profile the distinct expression of four extracellular vesicle‐derived miRNAs across different samples and ...
Zuowei Xie, Ruijia Deng, Ben Niu, Yingjie Yang, Shuang Zhao, Hongzhao Yang, Meilin Gong, Jie Luo, Yu Tang, Jing Sheng, Yan Pi, Ming Chen, Kai Chang   +12 more
wiley   +1 more source

Assessing Agricultural Green Total Factor Productivity in Latin America

Agribusiness, EarlyView.
ABSTRACT The agricultural sector in Latin America plays a vital role in ensuring food security while impacting the environment. However, there remains a lack of analysis regarding the inputs responsible for pollution within its sub‐technologies. Hence, this article aims to assess agricultural green total factor productivity (TFP) through a novel ...
Tianxiang Li, Vanessa Ormeño‐Candelario, Xueli Chen   +2 more
wiley   +1 more source

Thirty Years of Mentoring by “Bob Chan” of Young Japanese Surgeons to Become Scientists: An Adventure of Love

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Over the past three decades, we have mentored a generation of young Japanese surgeons, guiding them to become internationally recognized surgeon‐scientists. Through a unique collaboration between Japanese academic institutions and our laboratories at AntiCancer Inc.
Robert M. Hoffman, Kentaro Miyake, Itaru Endo   +2 more
wiley   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

The Far East as Resource: On Byung-Chul Han’s and François Jullien’s Critical Philosophy

Journal of Integrative and Innovative Humanities, 2022
The turn to non-Western thought is a phenomenon among Western philosophers (such as François Jullien in France and Byung-Chul Han in Germany) in the 21st century, especially in the face of the development and expansion of neoliberal capitalism that has ...
Kengkij Kitirianglarp
doaj  

Deng Xiaoping Theory: Practical Philosophy and Renewed Ideology of the Chinese Communist Party [PDF]

, 2020
V. Kiktenko
openalex   +1 more source

Robust Reinforcement Learning Control Framework for a Quadrotor Unmanned Aerial Vehicle Using Critic Neural Network

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Quadrotor unmanned aerial vehicle control is critical to maintain flight safety and efficiency, especially when facing external disturbances and model uncertainties. This article presents a robust reinforcement learning control scheme to deal with these challenges.
Yu Cai, Yefeng Yang, Tao Huang, Boyang Li   +3 more
wiley   +1 more source