Results 41 to 50 of about 5,826,092 (334)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Olfactory dysfunction and the role of stem cells in the regeneration of olfactory neurons

Heliyon
The prevalence of COVID-19 has drawn increasing attention to olfactory dysfunction among researchers. Olfactory dysfunction manifests in various clinical types, influenced by numerous pathogenic factors.
Pengju Yu, Weiguan Chen, Ling Jiang, Yufeng Jia, Xiaoyan Xu, Weiye Shen, Ni Jin, Hongjie Du   +7 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Nursing-led multidisciplinary ERAS collaboration improves early recovery after laparoscopic radical prostatectomy for localized prostate cancer: a retrospective cohort study

Frontiers in Medicine
BackgroundPostoperative recovery after laparoscopic radical prostatectomy (LRP) is influenced by perioperative nursing care. Therefore, this retrospective study aimed to compare outcomes from nursing-led perioperative multidisciplinary nursing ...
Chunmei Chen, Yumei Li, Xueyan Chen, Ping Zhang, Shuang Zhu   +4 more
doaj   +1 more source

Assessing the Sustainability of the Built Environment in Mountainous Rural Villages in Southwest China

Mountain Research and Development, 2016
Mountainous rural areas such as those in southwest China are developing rapidly. This requires scientific understanding and a framework for assessing the sustainability of the built environment that is suitable to such areas.
Li Wan, Edward Ng
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Psychometric evaluation of the perceived perioperative competence scale-revised among the Chinese operating room nurses: a methodological research

BMC Nursing, 2022
Background Perioperative competence is necessary to evaluate operating room nurses. The Perceived Perioperative Competence Scale-Revised (PPCS-R) is the only available tool developed specifically for the perioperative setting. However, there is a lack of
Qiaomeng Yu, Ran Wei, Yongting Wei, Xiuhong Wu, Tao Liang   +4 more
doaj   +1 more source

Turing Test, Chinese Room Argument, Symbol Grounding Problem. Meanings in Artificial Agents [PDF]

, 2012
The Turing Test (TT), the Chinese Room Argument (CRA), and the Symbol Grounding Problem (SGP) are about the question “can machines think?”. We propose to look at that question through the capability for Artificial Agents (AAs) to generate meaningful ...
Menant, Mr Christophe
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Exploring The Application Of Zen Aesthetic Interiors In Commercial Spaces The Interior Design Of A Tea Room in China

Anales de Investigación en Arquitectura, 2023
This study explores how a tea room in China integrates traditional Chinese culture and Zen aesthetics into interior design to give end users a good experience.
Yan Jia, Firzan Abdul Aziz
doaj