Results 231 to 240 of about 380,469 (307)

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

INFLUENCE OF MECHANICAL PRESSURE APPLIED ON THE CHANNEL COURSE UPON THE ACUPUNCTURE EFFECT

针刺研究, 1987
You Zhengquan, Hu Xianglong, Wu Baohua, Ye Shitao (Fujian Institute of Traditional Chinese Medicine)Zhong Yuerong, Lin Pinzhen   +4 more
doaj  

Comment on Huttasch et al. Increased Early Postprandial Glucagon Concentrations in Humans With Newly Diagnosed Type 2 Diabetes and Steatotic Liver Disease. [PDF]

Diabetes Care
Cao YT, Zhou XQ.
europepmc   +1 more source

Architected Inverse Nacre Hydrogels With High Strength and Crack‐Insensitive Toughness

Advanced Science, EarlyView.
Hydrogels hold promise for biomedical and engineering applications, yet their practical use is fundamentally limited by the strength‐toughness trade‐off and poor fatigue resistance. In this study, a bioinspired inverse nacre architecture constructed via a scalable thermo‐calendering process is introduced, which overcomes these classic limitations ...
Haidi Wu, Qin Su, Cheng Guan, Biwang Pan, Wenjie Hu, Jun Yan, Yifan Feng, Longcheng Tang, Xuewu Huang, Jiefeng Gao, Wancheng Gu   +10 more
wiley   +1 more source

Clinical analysis of drug treatment trends for coronary heart disease in China. [PDF]

Front Med (Lausanne)
Li X, Lou J, Li X, Li S, Gu J, Zhang D, Luo Z, Cao J, Xie J.   +8 more
europepmc   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Mechanisms of traditional Chinese medicine in enhancing the efficacy and reducing the toxicity of immune checkpoint inhibitors <i>via</i> regulation of the tumor microenvironment and gut microbiota. [PDF]

J Enzyme Inhib Med Chem
Pan J, Yang L, Wang H, Chen Y.
europepmc   +1 more source

Integrating Network Pharmacology and Clinical Observation to Elucidate the Therapeutic Mechanisms of Yangzheng Xiaoji Decoction in Primary Liver Cancer. [PDF]

Int J Gen Med
Yang S, Liu R, Wen S, Wang Y, Tai N, Tian J.   +5 more
europepmc   +1 more source

Immersive virtual reality for cognitive rehabilitation in patients who had a stroke: study protocol for a randomised controlled trial. [PDF]

BMJ Open
Li JL, Meng FL, Ma J, Wu JJ, He S, Zhang JP, Xu ZJ, Zheng YX, Mei YD, Hua XY, Xu JG.   +10 more
europepmc   +1 more source

THE EFFECTS OF MOXIBUSTION AT "ZUSANLI" POINT ON SERUM ENDOCRINE HORMONS OF RATS

针刺研究, 1989
Zhang Xiaohu, Yang Kening, Li Xinmin, Ma wenhin Changchun Chinese Traditional Medicine College Normane Bethune University of Medticel Science   +3 more
doaj