Results 111 to 120 of about 103,657 (215)

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Automated chromatin profiling with spa-ChIP-seq uncovers the impacts of condition variations. [PDF]

Genome Res
Cao Y, Patel L, Alcoser L, Mendenhall E, Benner C, Heinz S, Goren A.   +6 more
europepmc   +1 more source

Validating a re-implementation of an algorithm to integrate transcriptome and ChIP-seq data. [PDF]

PeerJ, 2023
Ahmed M, Kim DR.
europepmc   +1 more source

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

Analysis of Putative CzcR Targets Under Zinc Sufficiency and Zinc Excess Conditions in <i>Pseudomonas aeruginosa</i> Using ChIP-Seq. [PDF]

Microorganisms
Mauffrey F, Ducret V, Milho CG, Perron K.   +3 more
europepmc   +1 more source

Motif elucidation in ChIP-seq datasets with a knockout control. [PDF]

Bioinform Adv, 2023
Denisko D, Viner C, Hoffman MM.
europepmc   +1 more source

Stage‐Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis

Advanced Science, EarlyView.
Stage‐specific succinylation of histone H3 at lysine 14 and 23 differentially controls insect metamorphosis and oogenesis through distinct GPCR‐PKC signaling cascades, revealing an evolutionarily conserved epigenetic mechanism that coordinates key life‐history traits.
Yu‐Pu Jing, Lunjie Li, Libin Yang, Lin‐Jie Zhang, Qiang Yan, Ci Zhang, Zanrong Wen, Guangze Yu, Qian Li, Shutang Zhou   +9 more
wiley   +1 more source

CHIP-seq and transcriptomics reveal a new role of circadian-regulated StBBX24 protein in potato reproduction. [PDF]

BMC Plant Biol
Grądzka K, Biegańska M, Koczyk G, Młodzińska A, Pawłowicz I, Kiełbowicz-Matuk A.   +5 more
europepmc   +1 more source

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Evaluating Reproducibility and Best Practices for Replicate Design in G-Quadruplex ChIP-Seq Studies. [PDF]

Int J Mol Sci
Xiao K, Zhang R, Tu J.
europepmc   +1 more source