Results 101 to 110 of about 604,881 (306)
Advanced Science, EarlyView.This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao +7 more
wiley +1 more source
Informative sequence-based models for fragment distributions in ChIP-seq, RNA-seq and ChIP-chip data [PDF]
Many high throughput sequencing protocols for RNA and DNA require that the polynucleic acid is fragmented so that the identity of a limited number of nucleic acids of one or both of the ends of the fragments can be determined by sequencing. The nucleic
Dyer, Nigel
core
Nuclear RNA sequencing of the mouse erythroid cell transcriptome [PDF]
, 2012 Copyright @ 2012 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Umlauf David +39 more
core +2 more sources
ChIP-seq analysis using PbAP2-FG2::GFP.
, 2023 (A) IGV images showing peaks identified in the ChIP-seq experiment 1 and 2 of PbAP2-FG2 on the chromosome 1. Read coverage for the ChIP data is shown. (B) IDR1D analysis between the ChIP-seq experiment 1 and 2.
Izumi Kaneko (121023) +3 more
core +1 more source
TAF-ChIP: an ultra-low input approach for genome-wide chromatin immunoprecipitation assay
Life Science Alliance, 2019 The authors present a novel method for obtaining chromatin profiles from low cell numbers without prior nuclei isolation. The method is successfully implemented in generating epigenetic profile from 100 cells with high signal-to-noise ratio.
Junaid Akhtar +10 more
doaj +1 more source
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source
, 2014 (A) Schematic of our RNA-seq and ChIP-seq assays, showing the various antibodies used for ChIP-seq and the total number of peaks obtained for each antibody and treatment. (B) Overlap between DMSO and rifampin treated ChIP-seq peaks for each antibody.
Anuradha Ramamoorthy (638650) +14 more
core +1 more source
ATAC-seq and NFKB1 ChIP-seq peak pairwise normalized read count comparisons.
, 2022 Each dot represents a peak that is present in either of the two samples. The X- and Y-axis indicate the number of normalized read counts for that peak in the two samples.
Daniel Miller (424185) +18 more
core +1 more source
Androgen receptor DNA binding and chromatin accessibility profiling in prostate cancer
Genomics Data, 2016 Prostate cancer (PCa) is the second most common cancer in men. The Androgen Receptor (AR) is the major driver of PCa and the main target of therapy in the advanced setting.
Ekaterina Nevedomskaya +6 more
doaj +1 more source
Advanced Science, EarlyView.. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li +15 more
wiley +1 more source