Results 91 to 100 of about 574,514 (257)
ChIP-seq reveals extensive NF90/NF110 occupancy along the genome.
, 2018 (a) ChIP-seq signal (fold enrichment over input) of NF90/NF110 shown along chromosome one, along peaks called using Irreproducibility Discovery Rate (IDR) between biological replicates. UCSC known genes and transcripts are aligned.
Minyi Shi (179103) +6 more
core +1 more source
Advanced Healthcare Materials, EarlyView.We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett +7 more
wiley +1 more source
TAF-ChIP: an ultra-low input approach for genome-wide chromatin immunoprecipitation assay
Life Science Alliance, 2019 The authors present a novel method for obtaining chromatin profiles from low cell numbers without prior nuclei isolation. The method is successfully implemented in generating epigenetic profile from 100 cells with high signal-to-noise ratio.
Junaid Akhtar +10 more
doaj +1 more source
Methods, Challenges and Potentials of Single Cell RNA-seq [PDF]
, 2012 RNA-sequencing (RNA-seq) has become the tool of choice for transcriptomics. Several recent studies demonstrate its successful adaption to single cell analysis. This allows new biological insights into cell differentiation, cell-to-cell variation and gene
Daniel Hebenstreit, Hebenstreit, Daniel
core +1 more source
Advanced Healthcare Materials, EarlyView.A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull +11 more
wiley +1 more source
Androgen receptor DNA binding and chromatin accessibility profiling in prostate cancer
Genomics Data, 2016 Prostate cancer (PCa) is the second most common cancer in men. The Androgen Receptor (AR) is the major driver of PCa and the main target of therapy in the advanced setting.
Ekaterina Nevedomskaya +6 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li +9 more
wiley +1 more source
Bio-Protocol, 2017 Chromatin immunoprecipitation followed by massively parallel sequencing (ChIP-seq) is a powerful technology to profile genome-wide chromatin modification patterns and is increasingly being used to study the molecular mechanisms of brain diseases such as ...
Yong-Hwee Loh +3 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Three‐dimensional bioprinting transforms breast cancer modeling from simple constructs into spatially organized, multicellular, perfused, and patient‐derived platforms. This review shows how bioinks, cellular composition, architecture, and flow govern tumor behavior and drug response, while revealing why complexity alone is insufficient without ...
Mustafa Nakipoglu +7 more
wiley +1 more source