RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops. [PDF]
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Zhang X +13 more
europepmc +2 more sources
Chitin Triggers Tissue-Specific Immunity in Wheat Associated With Fusarium Head Blight
Fusarium graminearum is one of the primary causal agents of Fusarium head blight (FHB) on wheat and barley. FHB reduces grain yield and contaminates grain with various mycotoxins, including deoxynivalenol (DON).
Guixia Hao +2 more
doaj +1 more source
Fungal pathogens are among the main destructive microorganisms for crops and ecosystems worldwide, causing substantial agricultural and economic losses.
Lei Pi +5 more
doaj +1 more source
Chitin induces accumulation in tissue of innate immune cells associated with allergy [PDF]
Allergic and parasitic worm immunity is characterized by infiltration of tissues with interleukin (IL)-4- and IL-13-expressing cells, including T-helper-2 cells, eosinophils and basophils. Tissue macrophages assume a distinct phenotype, designated alternatively activated macrophages.
Tiffany A, Reese +6 more
openaire +2 more sources
TLR-2 and IL-17A in Chitin-Induced Macrophage Activation and Acute Inflammation [PDF]
Abstract Chitin is a ubiquitous polysaccharide in fungi, insects, and parasites. To test the hypothesis that chitin is an important immune modulator, we characterized the ability of chitin fragments to regulate murine macrophage cytokine production in vitro and induce acute inflammation in vivo. In this study, we show that chitin is a
Carla A, Da Silva +4 more
openaire +2 more sources
Exposure to various antigens derived from house dust mites (HDM) is considered to be a risk factor for development of certain allergic diseases such as atopic asthma, atopic dermatitis, rhinitis and conjunctivitis.
Ken Arae +14 more
doaj +1 more source
A structural and biochemical model of processive chitin synthesis [PDF]
Chitin synthases (CHS) produce chitin, an essential component of the fungal cell wall. The molecular mechanism of processive chitin synthesis is not understood, limiting the discovery of new inhibitors of this enzyme class.
Ferenbach, Andrew T. +3 more
core +1 more source
Chitin induces upregulation of B7‐H1 on macrophages and inhibits T‐cell proliferation [PDF]
AbstractChitin is a highly abundant glycopolymer, which serves as structural component in fungi, arthropods and crustaceans but is not synthesized by vertebrates. However, vertebrates express chitinases and chitinase‐like proteins, some of which are induced by infection with helminths suggesting that chitinous structures may be targets of the immune ...
Claudia J, Wagner +3 more
openaire +2 more sources
Arabidopsis ubiquitin ligase PUB12 interacts with and negatively regulates Chitin Elicitor Receptor Kinase 1 (CERK1). [PDF]
In Arabidopsis, fungal chitin is recognized as a pathogen-associated molecular pattern (PAMP) by the chitin receptor complex containing the lysin-motif (LysM) receptor-like kinases CERK1 and LYK5.
Koji Yamaguchi +4 more
doaj +1 more source
Chitin nanofiber elucidates the elicitor activity of polymeric chitin in plants
Chitin, an N-acetyl-D-glucosamine polymer, is a component of fungal cell walls and a microbe/pathogen-associated molecular pattern that elicits plant defense responses.
Mayumi eEgusa +7 more
doaj +1 more source

