Results 51 to 60 of about 19,286 (246)

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Fungal chitin dampens inflammation through IL-10 induction mediated by NOD2 and TLR9 activation.

PLoS Pathogens, 2014
Chitin is an essential structural polysaccharide of fungal pathogens and parasites, but its role in human immune responses remains largely unknown. It is the second most abundant polysaccharide in nature after cellulose and its derivatives today are ...
Jeanette Wagener, R K Subbarao Malireddi, Megan D Lenardon, Martin Köberle, Simon Vautier, Donna M MacCallum, Tilo Biedermann, Martin Schaller, Mihai G Netea, Thirumala-Devi Kanneganti, Gordon D Brown, Alistair J P Brown, Neil A R Gow   +12 more
doaj   +1 more source

Reciprocal Inhibition of Adiponectin and Innate Lung Immune Responses to Chitin and Aspergillus fumigatus

Frontiers in Immunology, 2019
Chitin is a structural biopolymer found in numerous organisms, including pathogenic fungi, and recognized as an immune-stimulating pathogen associated molecular pattern by pattern recognition molecules of the host immune system.
Nansalmaa Amarsaikhan, Dylan J. Stolz, Amber Wilcox, Ethan M. Sands, Angar Tsoggerel, Haley Gravely, Steven P. Templeton   +6 more
doaj   +1 more source

The grapevine LysM receptor-like kinase VvLYK5-1 recognizes chitin oligomers through its association with VvLYK1-1

Frontiers in Plant Science, 2023
The establishment of defense reactions to protect plants against pathogens requires the recognition of invasion patterns (IPs), mainly detected by plasma membrane-bound pattern recognition receptors (PRRs).
Thibault Roudaire, Tania Marzari, David Landry, Birgit Löffelhardt, Andrea A. Gust, Angelica Jermakow, Ian Dry, Pascale Winckler, Marie-Claire Héloir, Benoit Poinssot   +9 more
doaj   +1 more source

A Receptor-like Cytoplasmic Kinase Targeted by a Plant Pathogen Effector Is Directly Phosphorylated by the Chitin Receptor and Mediates Rice Immunity [PDF]

Cell Host & Microbe, 2013
CERK1 is a lysine motif-containing plant pattern recognition receptor for chitin and peptidoglycan. Chitin recognition by OsCERK1 triggers rapid engagement of a rice MAP kinase cascade, which leads to defense response activation. How the MAP kinase cascades are engaged downstream of OsCERK1 remains obscure.
Yamaguchi, Koji, Yamada, Kenta, Ishikawa, Kazuya, Yoshimura, Satomi, Hayashi, Nagao, Uchihashi, Kouhei, Ishihama, Nobuaki, Kishi-Kaboshi, Mitsuko, Takahashi, Akira, Tsuge, Seiji, Ochiai, Hirokazu, Tada, Yasuomi, Shimamoto, Ko, Yoshioka, Hirofumi, Kawasaki, Tsutomu   +14 more
openaire   +2 more sources

Microbial Hydrolysates as Amino Acid Source in Cell Culture Media for Cellular Agriculture

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The high cost of cultivation media remains one of the barriers to the commercialization of cultivated meat. Current serum‐free media reduce reliance on fetal bovine serum but only achieve modest cost savings. Especially at larger scales (> 20 m3), pharmaceutical‐grade amino acids and recombinant proteins remain major cost drivers.
Jelle C. Hoek, Jean‐Marc Daran, Marieke E. Klijn, Marcel A. Vieira‐Lara   +3 more
wiley   +1 more source

The soybean plasma membrane GmDR1 protein conferring broad-spectrum disease and pest resistance regulates several receptor kinases and NLR proteins

Scientific Reports
Overexpression of Glycine max disease resistant 1 (GmDR1) exhibits broad-spectrum resistance against Fusarium virguliforme, Heterodera glycines (soybean cyst nematode), Tetranychus urticae (Koch) (spider mites), and Aphis glycines Matsumura (soybean ...
Micheline N. Ngaki, Subodh K. Srivastava, Wang Feifei, Madan K. Bhattacharyya   +3 more
doaj   +1 more source

Current and emerging analytical technologies for analyzing chitin-protein binding interactions

Reviews in Analytical Chemistry, 2013
Chitin, a small organic molecule commonly found in fungal cell walls and insect exoskeletons, has the ability to elicit an immune response in plants by binding to specific membrane-bound receptors. Understanding how plants detect and fend off deleterious
Dahmen Jeremy L., Stacey Gary, Hunt Heather K.   +2 more
doaj   +1 more source

Cladosporium fulvum Avr4 Protects Fungal Cell Walls Against Hydrolysis by Plant Chitinases Accumulating During Infection

Molecular Plant-Microbe Interactions, 2006
Resistance against the leaf mold fungus Cladosporium fulvum is mediated by the tomato Cf proteins which belong to the class of receptor-like proteins and indirectly recognize extracellular avirulence proteins (Avrs) of the fungus.
Harrold A. van den Burg, Stuart J. Harrison, Matthieu H. A. J. Joosten, Jacques Vervoort, Pierre J. G. M. de Wit   +4 more
doaj   +1 more source

Advanced nanotherapeutics for combating ocular infections: Rational design, antimicrobial mechanisms, and therapeutic breakthroughs

BMEMat, EarlyView.
Nanomaterials revolutionize ocular infection treatment by enabling targeted drug delivery and enhanced antimicrobial efficacy against resistant pathogens. This review systematically explores their rational design, multimodal mechanisms, and translational potential for next‐generation anti‐infective therapies.
Yujia Liu, Xuetian Wen, Yue Tan, Rui Zeng, Yijuan Zhang, Tong Lin, Lan Gong, Zichao Luo   +7 more
wiley   +1 more source