Results 41 to 50 of about 60,304 (195)

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

Allergy, EarlyView.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake, Alexandra C. Brown, Nikhil T. Awatade, Philip M. Hansbro, Katherine J. Baines, Richard Y. Kim, Nathan W. Bartlett, Jay C. Horvat, Peter A. B. Wark   +8 more
wiley   +1 more source

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Chlamydia Persistence: A Survival Strategy to Evade Antimicrobial Effects in-vitro and in-vivo

Frontiers in Microbiology, 2018
The Chlamydiaceae comprise a group of highly adapted bacterial pathogens sharing a unique intracellular lifestyle. Three Chlamydia species are pathogenic to humans: Chlamydia trachomatis, Chlamydia pneumoniae, and Chlamydia psittaci. C.
Maria Emilia Panzetta, Raphael H. Valdivia, Hector Alex Saka   +2 more
doaj   +1 more source

Loss‐of‐Function Variants in CCDC189 Cause Human Oligoasthenoteratozoospermia by Disrupting Sperm Flagellar and Acrosomal Architecture

Andrology, EarlyView.
ABSTRACT Background Oligoasthenoteratozoospermia (OAT), characterized by reduced sperm count, impaired motility, and abnormal morphology, is a major cause of male infertility with substantial genetic heterogeneity. However, the underlying genetic etiology remains unresolved in a large proportion of affected individuals.
Jianteng Zhou, Ghulam Mustafa, Tingting Lin, Jingwei Ye, Huan Zhang, Hanwei Jiang, Kexin Yang, Guoning Huang, Qinghua Shi   +8 more
wiley   +1 more source

When two diseases collide: Endometriosis as a risk factor for severe pelvic inflammatory disease

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Endometriosis is associated with a more severe clinical course of pelvic inflammatory disease in hospitalized patients, including higher rates of antibiotic treatment failure, longer hospital stay, and increased need for surgical intervention. Abstract Introduction Our objective was to compare the severity of pelvic inflammatory disease (PID) in ...
Marta Camacho, Mariona Rius, Maria Angeles Martínez‐Zamora, Meritxell Gracia, Lara Quintas‐Marquès, Cristian De Guirior, Francisco Carmona, Cristina Ros   +7 more
wiley   +1 more source

Chlamydia induces anchorage independence in 3T3 cells and detrimental cytological defects in an infection model. [PDF]

PLoS ONE, 2013
Chlamydia are gram negative, obligate intracellular bacterial organisms with different species causing a multitude of infections in both humans and animals.
Andrea E Knowlton, Larry J Fowler, Rahul K Patel, Shannon M Wallet, Scott S Grieshaber   +4 more
doaj   +1 more source

Women's experiences, responses, and coping strategies when testing positive for human papillomavirus in cervical cancer screening: A qualitative study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
This study demonstrates that women's experiences following an hrHPV diagnosis within cervical screening extend beyond individual reactions to medical information, encompassing complex psychological, social, and cultural dimensions that influence how women interpret and manage the diagnosis.
Joan Hansen, Beth J. Maclin, Birgitte Folmann, Jane Ege Møller, Ane Kersti Skaarup Knudsen, Vibeke Raaby, Anne Hammer   +6 more
wiley   +1 more source

Impact of oral Chlamydia vaccination on host gut microbiome and metabolite composition

mSystems
Chlamydia trachomatis, an intracellular pathogen, is recognized as the most common sexually transmitted bacterial infection among women worldwide. Chlamydia infections can lead to undesirable clinical outcomes, including pelvic inflammatory disease and ...
Youyou Huang, Jiao Wan, Chuqiang Shu, Xichun Yan, Jingyue Ma, Tian Zhang, Jiarong He, Ziqing Wan, Guang Li, Qi Zhang, Zengzi Zhou, Xin Sun, Jing Zhao, Pu Zhang, Luying Wang, Tianyuan Zhang, Qi Tian   +16 more
doaj   +1 more source

Prevalence of Chlamydia trachomatis in adults with chronic conjunctivitis in Nišava district [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2012
Introduction. Chlamydia trachomatis causes many infections, including eye infections. They manifest as inclusion conjunctivitis and trachoma. The agent is transmitted by dirty hands, eyeliners, medical instruments and via swimming-pool water or, in ...
Inđić Nikola, Igić Ljiljana, Veselinović Aleksandar, Veselinović Dragan   +3 more
doaj   +1 more source

Chronic Ulcer on the Vulva

JEADV Clinical Practice, EarlyView.
Farhanaz Panjshiri, Reed Gioe, Carole Bitar   +2 more
wiley   +1 more source