Results 81 to 90 of about 3,721,767 (308)

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

Allergy, EarlyView.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake, Alexandra C. Brown, Nikhil T. Awatade, Philip M. Hansbro, Katherine J. Baines, Richard Y. Kim, Nathan W. Bartlett, Jay C. Horvat, Peter A. B. Wark   +8 more
wiley   +1 more source

A multi-strategy antimicrobial discovery approach reveals new ways to treat Chlamydia.

PLoS Biology
While the excessive use of broad-spectrum antibiotics is a major driver of the global antibiotic resistance crisis, more selective therapies remain unavailable for the majority of bacterial pathogens.
Magnus Ölander, Daniel Rea Vázquez, Karsten Meier, Aakriti Singh, Amanda Silva de Sousa, Fabiola Puértolas-Balint, Milica Milivojevic, Lieke Mooij, Johanna Fredlund, Eduard Calpe Bosch, María Rayón Díaz, Moa Lundgren, Karin van der Wal, Shaochun Zhu, André Mateus, Bjoern O Schroeder, Jeremy R Lohman, Barbara S Sixt   +17 more
doaj   +1 more source

Levels of different cytokines in women and men with asymptomatic genital infection caused by Chlamydia

Journal of Infection in Developing Countries, 2019
Introduction: Immune response to genital Chlamydia trachomatis infection is involved in both immunity and pathology. The cytokine profile during infection has been implicated in the disease outcome, either resolution or severe sequelae.
Alessandra Bua, Sara Cannas, Stefania Zanetti, Paola Molicotti   +3 more
doaj   +1 more source

The Cost-Effectiveness of Screening for Genital Chlamydial Infection in the UK [PDF]

This PhD thesis explores the cost-effectiveness of Chlamydia trachomatis (CT) screening, in the context of the National Chlamydia Screening Programme (NCSP) currently being implemented in England.
Adams, Elisabeth Jane
core   +1 more source

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Infections sexuellement transmissibles à Chlamydia trachomatis [PDF]

, 2017
Depuis quelques années, le diagnostic d’infection sexuellement transmissible à Chlamydia trachomatis est de plus en plus souvent posé. Les infections à Chlamydia, qui touchent principalement les jeunes femmes, sont redoutées en raison du risque d ...
Michal Yaron, Brigitte Frey Tirri, Axel Jeremias Schmidt, Michal, Yaron, Pietro Vernazza, Aebi Popp, Karoline, Calmy, Alexandra, Peter Itin, Nicola Low, Itin, Peter, Frank Bally, Jan Fehr, Philip Tarr, Notter, Julia, Fehr, Jan, Frey Tirri, Brigitte, Julia Notter, Alexandra Calmy, Tarr, Philip, David Nadal, Schmidt, Axel Jeremias, Christoph Hauser, Hauser, Christoph, Karoline Aebi Popp, Vernazza, Pietro, Nadal, David, Low, Nicola, Cavassini, Matthias, Matthias Cavassini, Bally, Frank   +29 more
core   +1 more source

Loss‐of‐Function Variants in CCDC189 Cause Human Oligoasthenoteratozoospermia by Disrupting Sperm Flagellar and Acrosomal Architecture

Andrology, EarlyView.
ABSTRACT Background Oligoasthenoteratozoospermia (OAT), characterized by reduced sperm count, impaired motility, and abnormal morphology, is a major cause of male infertility with substantial genetic heterogeneity. However, the underlying genetic etiology remains unresolved in a large proportion of affected individuals.
Jianteng Zhou, Ghulam Mustafa, Tingting Lin, Jingwei Ye, Huan Zhang, Hanwei Jiang, Kexin Yang, Guoning Huang, Qinghua Shi   +8 more
wiley   +1 more source

Pathogen-host reorganization during Chlamydia invasion revealed by cryo-electron tomography [PDF]

, 2014
Invasion of host cells is a key early event during bacterial infection, but the underlying pathogen-host interactions are yet to be fully visualised in three-dimensional detail.
Hayward, Richard, Nans, Andrea, Saibil, HR, Hayward, RD, Saibil, Helen R., Nans, A   +5 more
core   +1 more source

Prevalence, Treatment, and Outcomes of Corneal Disease in Aboriginal and Torres Strait Islander Peoples in Australia: A Systematic Review

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background To synthesise available evidence on the prevalence, treatment strategies, and outcomes of corneal disease affecting Aboriginal and Torres Strait Islander peoples in Australia, and to identify gaps in the existing literature. Methods A systematic review with narrative synthesis was conducted in accordance with PRISMA 2020 guidelines.
Angus van der Nagel, Daniel Cool, Himal Kandel, Stephanie Watson   +3 more
wiley   +1 more source

A case of prosthetic joint septic arthritis caused by Gordonia jacobaea

Journal of Microbiology, Immunology and Infection, 2022
Jennifer Guiraud, Maëlig Lescure, Deborah Faganello, Cécile Bébéar, Sabine Pereyre, Armelle Ménard   +5 more
doaj   +1 more source