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Background Chlamydia trachomatis, an obligate intracellular human pathogen, is the most prevalent bacterial sexually transmitted infection worldwide and a leading cause of preventable blindness.
Mathews Sarah A +3 more
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Pathogen-host reorganization during Chlamydia invasion revealed by cryo-electron tomography [PDF]
Invasion of host cells is a key early event during bacterial infection, but the underlying pathogen-host interactions are yet to be fully visualised in three-dimensional detail.
Hayward, Richard +5 more
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Chlamydia trachomatis diagnostics [PDF]
Nucleic acid amplification (NAA) assays for the diagnosis of Chlamydia trachomatis infections started to appear in the peer reviewed literature about 12 years ago and during that period we have seen an incredible effort put into the development and evaluation of commercially developed NAA kits to diagnose and treat infections.
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Costs of testing for ocular Chlamydia trachomatis infection compared to mass drug administration for trachoma in the Gambia: application of results from the PRET study. [PDF]
BACKGROUND: Mass drug administration (MDA) treatment of active trachoma with antibiotic is recommended to be initiated in any district where the prevalence of trachoma inflammation, follicular (TF) is ≥ 10% in children aged 1-9 years, and then to ...
Jaskiran K. Dhanjal +73 more
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Background: Genital Chlamydia trachomatis is a common bacterial cause of sexually transmitted infection worldwide which is associated with significant morbidity and has a great impact on human reproduction and fertility.
Attah RA, Ahmed MS, muhammad Z
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Immunity to Chlamydia trachomatis [PDF]
In this issue of the Journal, Geisler and colleagues [1] report convincing epidemiologicalevidencethatcervicalinfection with Chlamydia trachomatis produces immunity in at least a subset of naturally infected women. Over a 2.5-year period, they enrolled 243 C. trachomatis–infected women in a treatment study.
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Studies of human immune responses to various antigenic proteins of Chlamydia trachomatis [PDF]
Chlamydiae are gram-negative bacteria which cause diverse diseases of humans and animals. Chlamydia trachomatis, the focus of this work, causes the blinding eye disease trachoma, and reproductive tract infections.
Felton, John Mark
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Penicillin kills chlamydia following the fusion of bacteria with Lysosomes and prevents genital inflammatory lesions in C. muridarum-infected mice [PDF]
The obligate intracellular bacterium Chlamydia exists as two distinct forms. Elementary bodies (EBs) are infectious and extra-cellular, whereas reticulate bodies (RBs) replicate within a specialized intracellular compartment termed an ‘inclusion ...
Le Gall, SM +41 more
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The natural history of trachoma infection and disease in a Gambian cohort with frequent follow-up. [PDF]
BACKGROUND: The natural history of ocular Chlamydia trachomatis infections in endemic communities has not been well characterised and is an important determinant of the effectiveness of different mass treatment strategies to prevent blindness due to ...
Nicholas C Grassly +14 more
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Estrogens and Chlamydia trachomatis
Isolates of Chlamydia trachomatis were inoculated in nonreplicating McCoy cells and incubated for 48 hr with various concentrations of hormones. Only the estrogens, particularly 17-beta-estradiol, had an affect on the subsequent infection of the McCoy cells by the Chlamydia.
B, Sugarman, P, Agbor
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