Results 61 to 70 of about 27,918 (208)
Persistent Cup Product Structures and Related Invariants [PDF]
One-dimensional persistent homology is arguably the most important and heavily used computational tool in topological data analysis. Additional information can be extracted from datasets by studying multi-dimensional persistence modules and by utilizing cohomological ideas, e.g.~the cohomological cup product.
arxiv
Persistent chlamydiae: from cell culture to a paradigm for chlamydial pathogenesis
Chlamydiae are medically important bacteria responsible for a wide range of human infections and diseases. Repeated episodes of infection promote chronic inflammation associated with detrimental immune system-mediated pathologic changes. However, the true nature of chlamydial pathogenesis may encompass repeated infection superimposed upon persistent ...
Gerald I. Byrne+2 more
openaire +3 more sources
The role of tryptophan in Chlamydia trachomatis persistence
Chlamydia trachomatis (C. trachomatis) is the most common etiological agent of bacterial sexually transmitted infections (STIs) and a worldwide public health issue. The natural course with C. trachomatis infection varies widely between individuals.
Li Wang+7 more
doaj +1 more source
New therapeutic strategies are needed to overcome drawbacks in treatment of infections with intracellular bacteria. Chlamydiaceae are Gram-negative bacteria implicated in acute and chronic diseases such as abortion in animals and trachoma in humans ...
Hanna Marti+4 more
doaj +1 more source
The microfluidic Cervix Chip is an in vitro model of the human cervix lined by cervical epithelium interfaced with stromal cells cultured under dynamic flow that represents a new preclinical platform for studying mucosal immunity, host‐microbiome interactions, infections, fertility, and pregnancy health.
Zohreh Izadifar+4 more
wiley +1 more source
Beyond Tryptophan Synthase: Identification of Genes That Contribute to Chlamydia trachomatis Survival during Gamma Interferon-Induced Persistence and Reactivation [PDF]
Chlamydia trachomatis can enter a viable but nonculturable state in vitro termed persistence. A common feature of C. trachomatis persistence models is that reticulate bodies fail to divide and make few infectious progeny until the persistence-inducing ...
Brothwell, Julie A.+5 more
core +1 more source
Abstract Objective Tubo‐ovarian abscesses (TOAs) cause significant morbidity. Surgical intervention is required if broad‐spectrum intravenous antibiotics are unsuccessful. This study aimed to describe admission characteristics that predict failed medical management and to evaluate a previously developed risk score for predicting the need for surgical ...
Anna Marshall+6 more
wiley +1 more source
Quantum Persistent Homology [PDF]
Persistent homology is a powerful mathematical tool that summarizes useful information about the shape of data allowing one to detect persistent topological features while one adjusts the resolution. However, the computation of such topological features is often a rather formidable task necessitating the subsampling the underlying data. To remedy this,
arxiv
Rare Infectious Diseases: Detection and Clinical Implications
Rare infectious diseases are infections that are uncommon, have a low incidence, and are caused by newly emerging pathogens, cross‐species or ectopic infections, or host immunodeficiencies. The detection and diagnosis of rare infections is one of the main reasons for misdiagnosis and missed diagnosis.
Xin Qian+7 more
wiley +1 more source
In vitro susceptibility of recent Chlamydia trachomatis clinical isolates to the CtHtrA inhibitor JO146 [PDF]
© 2015 Institut Pasteur. The present study aimed to establish if a previously identified Chlamydia trachomatis HtrA (CtHtrA) inhibitor, JO146, is effective against currently circulating clinical isolates to validate if CtHtrA is a clinically relevant ...
Allan, JA+8 more
core +3 more sources