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British society for haematology 64th annual scientific meeting 2024. [PDF]
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The metabolism of chlorambucil
Biochemical Pharmacology, 1980Abstract After injection of chlorambucil into rats, metabolites have been isolated from blood and identified by g.l.c.-mass spectrometry as ( E )-4-[4 N , N -bis (2-chloroethyl)aminophenyl] 3-butenoic acid (3,4-dehydrochlorambucil) and 2-[4- N , N -bis (2-chloroethyl)aminophenyl] acetic acid (phenyl acetic acid mustard). Analysis of urine 24 hr after
Geoffrey Baker +3 more
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Cancer, 1997
Anecdotal reports of chlorambucil-induced seizures have sporadically appeared, mainly in the nononcologic literature. The majority of cases have occurred in patients treated with high dose therapy and in children with nephrotic syndrome. Because of its rarity, oncologists and hematologists may not be aware of this potential complication.Two elderly ...
E Salloum +2 more
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Anecdotal reports of chlorambucil-induced seizures have sporadically appeared, mainly in the nononcologic literature. The majority of cases have occurred in patients treated with high dose therapy and in children with nephrotic syndrome. Because of its rarity, oncologists and hematologists may not be aware of this potential complication.Two elderly ...
E Salloum +2 more
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Mechanism and reactivity of chlorambucil and chlorambucil–spermidine conjugate
J. Chem. Soc., Perkin Trans. 2, 1995The mechanism and kinetics of hydrolysis of chlorambucil and chlorambucil–spermidine conjugate in aqueous buffered solutions have been compared. In the absence of added chloride ion the reactions are shown to be first-order in the nitrogen mustard and independent of the nucleophile concentration.
CULLIS, PM, GREEN, RE, MALONE, ME
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Busulfan and Chlorambucil [PDF]
Hospital Pharmacy, 1999 The increasing complexity of cancer chemotherapy makes it mandatory that pharmacists be familiar with these highly toxic agents. This column reviews various issues related to the preparation, dispensing, and administration of cancer chemotherapy, both commercially available and investigational.
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Acta Haematologica, 1990
A 67-year-old man, who had received intermittent courses of oral chlorambucil and prednisone as therapy for chronic lymphocytic leukaemia over a period of 3.5 years, developed fatal lung fibrosis. A case report and brief review of the current data on chlorambucil-induced lung disease are presented.
Mark Power Smith +2 more
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A 67-year-old man, who had received intermittent courses of oral chlorambucil and prednisone as therapy for chronic lymphocytic leukaemia over a period of 3.5 years, developed fatal lung fibrosis. A case report and brief review of the current data on chlorambucil-induced lung disease are presented.
Mark Power Smith +2 more
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Response to Chlorambucil in Macroglobulinemia
JAMA, 1963MACROGLOBULINEMIA has been the subject of many reports and of several recent reviews. 1-3 Waldenstrom 4 first noted the occurrence of high molecular weight serum globulins as a prominent feature of certain blood dyscrasias. Despite the possibility of multiple etiologic factors, the well-defined biochemical abnormality and a generally recognized ...
Ovid O. Meyer, Dallas V. Clatanoff
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Chlorambucil-Associated Pneumonitis
Chest, 1994A patient developed an interstitial pneumonitis while receiving chlorambucil for a chronic lymphocytic leukemia (cumulative dose, 8,340 mg). Withdrawal of drug treatment was followed by rapid improvement in the clinical condition. Bronchoalveolar lavage showed a T-lymphocytic alveolitis, whereas blood lymphocytes were predominantly of the B phenotype ...
J. Frija +5 more
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Chest, 1980
Ten patients with biopsy-proven sarcoidosis with progressive disease were treated with chlorambucil alone or in combination with corticosteroids. Eight of these ten patients showed some degree of improvement which may be attributable to chlorambucil. The responsive patients showed beneficial effects within three months of starting chlorambucil therapy.
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Ten patients with biopsy-proven sarcoidosis with progressive disease were treated with chlorambucil alone or in combination with corticosteroids. Eight of these ten patients showed some degree of improvement which may be attributable to chlorambucil. The responsive patients showed beneficial effects within three months of starting chlorambucil therapy.
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Malignancies induced by chlorambucil
Cancer Treatment Reviews, 1984There is a high incidence of acute myeloid leukaemia in patients who have been treated with chlorambucil. This appears at least in part to be directly due to the drug itself and cannot be attributed to the disease processes for which the drug is given.
R.G. Palmer, A.M. Denman
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