Results 231 to 240 of about 24,793 (292)

Pulmonary disease with chlorambucil therapy [PDF]

Cancer, 1978
A 73-year-old female developed pulmonary disease during treatment with chlorambucil for polycythemia vera. Cough and dyspnea were prominent symptoms. A chest roentgenogram revealed interstitial fibrosis. The diffusing capacity was markedly reduced. Pathologic findings included alveolar lining cell dysplasia, interstitial round cell infiltrates and ...
Alan U. Klatsky, Solon R. Cole, Thomas J. Myers   +2 more
openaire   +4 more sources

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Acalabrutinib ± obinutuzumab versus obinutuzumab + chlorambucil in treatment-naïve chronic lymphocytic leukemia: Elevate-TN four-year follow up.

, 2021
7509Background: Early results from ELEVATE-TN (NCT02475681) at a median follow-up of 28.3 mo demonstrated superior efficacy of acalabrutinib (A) ± obinutuzumab (O) compared with O + chlorambucil (C...
J. Sharman, M. Egyed, W. Jurczak, A. Skarbnik, J. Pagel, M. Kamdar, T. Munir, G. Corbett, L. Fogliatto, Y. Herishanu, V. Banerji, S. Coutre, P. Walker, K. Karlsson, P. Ghia, A. Janssens, W. Wierda, P. Patel, M. Wang, J. Byrd   +19 more
semanticscholar   +1 more source

The metabolism of chlorambucil

Biochemical Pharmacology, 1980
Abstract After injection of chlorambucil into rats, metabolites have been isolated from blood and identified by g.l.c.-mass spectrometry as ( E )-4-[4 N , N -bis (2-chloroethyl)aminophenyl] 3-butenoic acid (3,4-dehydrochlorambucil) and 2-[4- N , N -bis (2-chloroethyl)aminophenyl] acetic acid (phenyl acetic acid mustard). Analysis of urine 24 hr after
Geoffrey Baker, Angus Mclean, Thomas A. Connors, David R. Newell   +3 more
openaire   +3 more sources

A peptide-drug hydrogel to enhance the anti-cancer activity of chlorambucil.

Biomaterials Science, 2020
The clinical applications of nitrogen mustard antitumor drugs are limited by their poor aqueous solubility, poor cellular uptake, lack of targeting, and severe side effects.
Qingxiang Guo, Yifan Liu, Ganen Mu, Lijun Yang, Wei Wang, Jinjian Liu, Jianfeng Liu   +6 more
semanticscholar   +1 more source

Mechanism and reactivity of chlorambucil and chlorambucil–spermidine conjugate

J. Chem. Soc., Perkin Trans. 2, 1995
The mechanism and kinetics of hydrolysis of chlorambucil and chlorambucil–spermidine conjugate in aqueous buffered solutions have been compared. In the absence of added chloride ion the reactions are shown to be first-order in the nitrogen mustard and independent of the nucleophile concentration.
CULLIS, PM, GREEN, RE, MALONE, ME
openaire   +3 more sources

Chlorambucil-induced seizures

Cancer, 1997
Anecdotal reports of chlorambucil-induced seizures have sporadically appeared, mainly in the nononcologic literature. The majority of cases have occurred in patients treated with high dose therapy and in children with nephrotic syndrome. Because of its rarity, oncologists and hematologists may not be aware of this potential complication.Two elderly ...
E Salloum, Dennis L. Cooper, Kalsoom K. Khan   +2 more
openaire   +3 more sources

Busulfan and Chlorambucil [PDF]

Hospital Pharmacy, 1999
The increasing complexity of cancer chemotherapy makes it mandatory that pharmacists be familiar with these highly toxic agents. This column reviews various issues related to the preparation, dispensing, and administration of cancer chemotherapy, both commercially available and investigational.
openaire   +1 more source

Chlorambucil-Associated Pneumonitis

Chest, 1994
A patient developed an interstitial pneumonitis while receiving chlorambucil for a chronic lymphocytic leukemia (cumulative dose, 8,340 mg). Withdrawal of drug treatment was followed by rapid improvement in the clinical condition. Bronchoalveolar lavage showed a T-lymphocytic alveolitis, whereas blood lymphocytes were predominantly of the B phenotype ...
J. Frija, Bruno Crestani, Louis-Jean Couderc, Dominique Israel-Biet, Arnaud Jaccard, Jean-Pierre Clauvel   +5 more
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Photocontrolled Release of the Anticancer Drug Chlorambucil with Caged Harmonic Nanoparticles

, 2020
While chemotherapy is one of the most used treatments in oncology, the systemic administration of chemotherapeutics generally results in undesired damages to healthy tissues and cells, side effects such as severe nausea and leukopenia, and reduced ...
J. Vuilleumier, G. Gaulier, Raphaël De Matos, Y. Mugnier, G. Campargue, J. Wolf, L. Bonacina, S. Gerber‐Lemaire   +7 more
semanticscholar   +1 more source

Chlorambucil Lung Toxicity

Acta Haematologica, 1990
A 67-year-old man, who had received intermittent courses of oral chlorambucil and prednisone as therapy for chronic lymphocytic leukaemia over a period of 3.5 years, developed fatal lung fibrosis. A case report and brief review of the current data on chlorambucil-induced lung disease are presented.
Mark Power Smith, Ah Goldstone, F J Giles   +2 more
openaire   +3 more sources