Results 241 to 250 of about 24,793 (292)
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Response to Chlorambucil in Macroglobulinemia
JAMA, 1963MACROGLOBULINEMIA has been the subject of many reports and of several recent reviews. 1-3 Waldenstrom 4 first noted the occurrence of high molecular weight serum globulins as a prominent feature of certain blood dyscrasias. Despite the possibility of multiple etiologic factors, the well-defined biochemical abnormality and a generally recognized ...
Ovid O. Meyer, Dallas V. Clatanoff
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Chest, 1980
Ten patients with biopsy-proven sarcoidosis with progressive disease were treated with chlorambucil alone or in combination with corticosteroids. Eight of these ten patients showed some degree of improvement which may be attributable to chlorambucil. The responsive patients showed beneficial effects within three months of starting chlorambucil therapy.
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Ten patients with biopsy-proven sarcoidosis with progressive disease were treated with chlorambucil alone or in combination with corticosteroids. Eight of these ten patients showed some degree of improvement which may be attributable to chlorambucil. The responsive patients showed beneficial effects within three months of starting chlorambucil therapy.
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The comparative toxicity of chlorambucil and chlorambucil-spermidine conjugate to BALBc mice
Cancer Letters, 1994The acute intraperitoneal toxicities of chlorambucil and chlorambucil-spermidine conjugate have been compared, in mice. Both compounds were neurotoxic and also caused a prolonged fall in bodyweight and a depletion of lymphocyte numbers associated with a fall in the total leukocyte count and loss of spleen and thymus weight. Alanine aminotransferase and
Verschoyle, RD +4 more
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Malignancies induced by chlorambucil
Cancer Treatment Reviews, 1984There is a high incidence of acute myeloid leukaemia in patients who have been treated with chlorambucil. This appears at least in part to be directly due to the drug itself and cannot be attributed to the disease processes for which the drug is given.
R.G. Palmer, A.M. Denman
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Chemical Communications, 2019
Supramolecular drug delivery systems are becoming an increasingly important part in controlled drug release. In this work, we report a novel enzyme-responsive supramolecular assembly directly constructed using biocompatible sulfato-β-cyclodextrin (SCD ...
X. Guan +4 more
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Supramolecular drug delivery systems are becoming an increasingly important part in controlled drug release. In this work, we report a novel enzyme-responsive supramolecular assembly directly constructed using biocompatible sulfato-β-cyclodextrin (SCD ...
X. Guan +4 more
semanticscholar +1 more source
The alkylating properties of chlorambucil
Pharmacology Biochemistry and Behavior, 1994Previous work has indicated an aziridinium ion mechanism in the hydrolysis of chlorambucil, and the present work on the alkylation of nucleophiles fully supports this mechanism. This mechanism forms the basis for understanding the kinetics of alkylation reactions because their rates are limited by the rate of formation of the aziridinium ion and the ...
Irwin B. Wilson +2 more
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ACS Applied Polymer Materials, 2019
Utilization of nitrogen mustards as anticancer drugs opened the way for precise cancer chemotherapy owing to their ability to cross-link deoxyribonucleic acid (DNA).
B. Saha +4 more
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Utilization of nitrogen mustards as anticancer drugs opened the way for precise cancer chemotherapy owing to their ability to cross-link deoxyribonucleic acid (DNA).
B. Saha +4 more
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Supramolecular Hydrogel Based on Chlorambucil and Peptide Drug for Cancer Combination Therapy.
ACS Applied Materials and Interfaces, 2018Supramolecular hydrogels of self-assembling peptide-drug conjugates have been considered as effective self-delivery drug systems for cancer therapy in recent years.
Lijun Yang +8 more
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Interaction of chlorambucil with tRNA
Canadian Journal of Biochemistry, 1978Preincubation of purified mixed tRNAs from Escherichia coli K12-MO with 2.94 mM chlorambucil (CAB) for 2 h at 37 °C results in the inhibition of the capacity of mixed tRNAs to accept alanine, arginine, asparagine, aspartic acid, glutamic acid, glutamine, glycine, histidine, isoieucine, leucine, lysine, methionine, phenylalanine, proline, serine ...
Hunsaker Wr, Dotzlaf Af, Brecher As
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Interstitial Pneumonia and Chlorambucil
Chest, 1979A case of interstitial pneumonia partially and spontaneously cured in ten months is presented. Chlorambucil as a possible etiology is discussed.
F.B. Michel, J.P. Marty, Ph. Godard
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