Results 251 to 260 of about 24,793 (292)
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Degradation of Chlorambucil in Aqueous Solution
Journal of Pharmaceutical Sciences, 1980The stability of chlorambucil and its degradation product 4-[p-(2-chloroethyl-2-hydroxyethylamino)phenyl]butyric acid (I) was studied using reversed-phase high-pressure liquid chromatography. The degradation rate of chlorambucil was unaffected by pH between pH 5 and 10 but decreased at lower pH. The degradation rates of chlorambucil and I differed only
Staffan Eksborg +3 more
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Cutaneous Reaction to Chlorambucil
Archives of Dermatology, 1977To the Editor.— Chlorambucil is an oral alkylating agent that has been used since early 1950, particularly for the treatment of chronic lymphatic leukemia. The side effects are gastrointestinal symptoms, such as nausea and vomiting, and bone marrow depression. Allergic skin reactions are extremely rare.
S. M. Rajah, L. G. Millard
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ACS Applied Nano Materials, 2018
In this paper, we have developed photoresponsive fluorescent organic nanoconjugates based on a single-component system for effective cancer treatment by a synergistic combination of photodynamic therapy (PDT) and chemotherapy. Our single-component system
A. Chaudhuri +6 more
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In this paper, we have developed photoresponsive fluorescent organic nanoconjugates based on a single-component system for effective cancer treatment by a synergistic combination of photodynamic therapy (PDT) and chemotherapy. Our single-component system
A. Chaudhuri +6 more
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Chlorambucil and Acute Intermittent Porphyria
Clinical Oncology, 2002A 54-year-old women with quiescent acute intermittent porphyria (AIP) developed low-grade non-Hodgkin's lymphoma. She was successfully treated with chlorambucil without any significant rise in urinary proto-porphyrins. The case is described and a review of chemotherapy use in AIP is presented.
S.J. Whitaker, J.H. Davies
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THE ONCOGENICITY OF CHLORAMBUCIL IN RHEUMATOID ARTHRITIS
Rheumatology, 1988Chlorambucil is useful in patients with rheumatoid arthritis (RA) refractory to other agents but there is concern about the risk of haematological malignancy with this agent. A retrospective survey was performed to assess the incidence of all types of malignancy in 39 patients treated with chlorambucil (mean daily dose 4.25 mg, mean duration of ...
Milton Cohen +6 more
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The pharmacokinetics of prednimustine and chlorambucil in the rat
Cancer Chemotherapy and Pharmacology, 1981In the rat prednimustine, the prednisolone ester of chlorambucil, is much less toxic than equimolar doses of chlorambucil, when administered subcutaneously (SC). This is due to differences in alkylating agent pharmacokinetics. Prednimustine injected SC produced low plasma concentrations (less than 5 microM) of the alkylating metabolites chlorambucil ...
D. R. Newell +2 more
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Angewandte Chemie, 2016
Among the well-known phototriggers, the p-hydroxyphenacyl (pHP) group has consistently enabled the very fast, efficient, and high-conversion release of active molecules.
Shrabani Barman +7 more
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Among the well-known phototriggers, the p-hydroxyphenacyl (pHP) group has consistently enabled the very fast, efficient, and high-conversion release of active molecules.
Shrabani Barman +7 more
semanticscholar +1 more source
Medical Hypotheses, 1980
Chlorambucil alkylation of pyridine, a model for nucleotides, appears to be first order in chlorambucil, but zero order in pyridine, and is strongly inhibited by dimethylsulfoxide. The same results are seen with chlorambucilyl [3H]prolyl proline; full alkylation activity was regained upon removal of dimethylsulfoxide.
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Chlorambucil alkylation of pyridine, a model for nucleotides, appears to be first order in chlorambucil, but zero order in pyridine, and is strongly inhibited by dimethylsulfoxide. The same results are seen with chlorambucilyl [3H]prolyl proline; full alkylation activity was regained upon removal of dimethylsulfoxide.
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A Binding Site for Chlorambucil on Metallothionein
Biochemistry, 1996It is of interest to test the hypothesis that induced metallothionein (MT) acts in acquired drug resistance by covalent sequestration. In this study MT was incubated in vitro with chlorambucil (CHB) under conditions where only 1:1 covalent adducts were formed.
Joseph Zaia +6 more
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Treatment of Behcet's Disease With Chlorambucil
Archives of Ophthalmology, 1970Eleven patients with Behcet's (and neuro-Behcet's) disease in the active and progressive stages were treated with chlorambucil (Leukeran). Follow-up varied between three weeks and 17 months. Results were favorable in all, and the drug was superior to other forms of treatment in that there was arrest and some amelioration of the disease.
Jubran G. Mamo, Samir A. Azzam
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