Results 261 to 270 of about 24,793 (292)
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Study of Chlorambucil and Chlorambucil–Trimethyl-β-cyclodextrin Inclusion Complex by CE
Chromatographia, 2007The results of CE studies of solid inclusion complexes of chlorambucil (CHL) and trimethyl-β-cyclodextrin (TM-β-CD) are presented. Chlorambucil has low stability in aqueous solution, so the formation of complexes with β-CD is a good way to improve its stability and dissolution. The experimental results confirm the existence of inclusion complexes.
Marco A. Leyva +10 more
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Kinetics and Mechanism of Chlorambucil Hydrolysis
Journal of Pharmaceutical Sciences, 1979The kinetics and mechanism of hydrolysis of the cytotoxic drug chlorambucil were investigated. A study of the reaction order and of the pH, dielectric constant, and ionic strength effects on the reaction rate revealed that the hydrolysis was a limiting unimolecular nucleophilic substitution, the rate-determining step being the ionization of the first 2-
Owen W.R., Stewart P.J.
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Potentiation of chlorambucil activity by phenylbutazone
Cancer Letters, 1978Phenylbutazone increased the cytotoxicity of chlorambucil to L1210 and P388 leukemia cells in vitro by displacing alkylating agent bound to serum of the tissue culture medium. Administration of phenylbutazone with chlorambucil to mice bearing the P388 tumor lowers the dose of chlorambucil required to achieve maximum increase in life span, but also ...
Yoshimasa Uehara +3 more
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Polymer-Chlorambucil Drug Conjugates: A Dynamic Platform of Anticancer Drug Delivery.
Macromolecular rapid communications, 2016Recently, polymer drug conjugates (PDCs) have attracted considerable attention in the treatment of cancer. In this work, a simple strategy has been developed to make PDCs of an antitumor alkylating agent, chlorambucil, using a biocompatible disulphide ...
B. Saha, Ujjal Haldar, Priyadarsi De
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Chlorambucil Therapy in Sympathetic Ophthalmia
American Journal of Ophthalmology, 1995We used chlorambucil therapy in a 28-year-old man with sympathetic ophthalmia, which was incompletely controlled with systemic corticosteroids, and the patient developed serious side effects.The patient sustained a penetrating injury with an intraocular metal foreign body. Attempts to remove it with a magnet failed.
Jorn Hon Liu, Chang-Sue Yang
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Effects of Chlorambucil on human chromosomes
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1973Abstract No significant amount of chromosomal damage was found in the 48-h cultures of lymphocytes of 18 patients who had been treated with the bifunctional alkylating agent chlorambucil (CBC). However, there was suggestive evidence of chromatid damage ( i.e. of types attributable to damage during or after DNA synthesis in the cell cycle). In marrow
Alan C. Stevenson, Chandrakant Patel
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Chlorambucil carcinogenesis in BALBc mice
Cancer Letters, 1990Chlorambucil, a drug used in the treatment of neoplastic and non-neoplastic disease, was administered by gavage to BALB/c mice at a dose of 1.0 mg/kg body wt. 5 times per week for 12 weeks to test its carcinogenicity. The survival was statistically reduced in treated animals of both sexes (P less than 0.001).
Antonio Cavaliere +3 more
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Chlorambucil in Behçet's Disease
Ophthalmology, 1983Ten patients with Behçet's disease were treated with chlorambucil alone. At the therapeutic drug level of 0.2 mg/kg, seven patients developed oligospermia and three patients developed azoospermia. A 30-year-old patient underwent a testicular biopsy two years after the cessation of therapy. Histopathology revealed evidence of testicular atrophy. Fifteen
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Lichen Myxedematosus Treated with Chlorambucil
The Journal of Dermatologic Surgery and Oncology, 1993BACKGROUND. Chemotherapy with various alkylating agents has been reported to be successful in the treatment of lichen myxedematosus. However, serious toxicities have accompanied such use.OBJECTIVE. To report a case of treatment of lichen myxedematosus with chlorambucil.RESULT.
Keyoumars Soltani +3 more
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Necrobiotic xanthogranuloma: Response to chlorambucil
Australasian Journal of Dermatology, 2010ABSTRACTThis report of necrobiotic xanthogranuloma associated with chronic lymphocytic leukaemia describes the response of skin lesions to chlorambucil. Characteristic clinical and histological features of necrobiotic xanthogranuloma are presented, as well as a discussion regarding management and the use of chlorambucil.
Lachlan Warren, Ferenc Szabo, Emma Ryan
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