Results 41 to 50 of about 8,937 (172)

Acute and Chronic Leukemia in Sub‐Saharan Africa: A Systematic Review

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background The four primary subgroups of leukemia include chronic myeloid leukemia (CML), acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and chronic lymphocytic leukemia (CLL). Very little is known about the regional variation of leukemia and subtypes in sub‐Saharan Africa (SSA).
Allwell A. Ayirebi, Stephen Twumasi, Linda K. Olaga, Benedict Sackey, Daniel N. M. Antonio, Richard O. Ansah, Eugene A. Ansah, John A. Sah, Enoch O. Anto, Yvonne Anang‐Quartey, Antoinette Koomson, Angela Opoku, Godfred A. Donkor, Paulina Duah, Ama G. Boadu, Samuel Essien‐Baidoo, Wina I. O. Boadu, Lilian A. Boateng   +17 more
wiley   +1 more source

Combined Application of CAR-T Cells and Chlorambucil for CLL Treatment: Insights from Nonlinear Dynamical Systems and Model-Based Design for Dose Finding

Hemato
Background: This work presents a mechanistic nonlinear model, formulated as a system of first-order Ordinary Differential Equations, to investigate the dynamics of Chronic Lymphocytic Leukemia (CLL) under combined chemoimmunotherapy using CAR-T cells and
Paul A. Valle, Luis N. Coria, Yolocuauhtli Salazar, Corina Plata, Luis A. Ramirez   +4 more
doaj   +1 more source

New potential therapeutic approach for the treatment of B-Cell malignancies using chlorambucil/hydroxychloroquine-loaded anti-CD20 nanoparticles. [PDF]

PLoS ONE, 2013
Current B-cell disorder treatments take advantage of dose-intensive chemotherapy regimens and immunotherapy via use of monoclonal antibodies. Unfortunately, they may lead to insufficient tumor distribution of therapeutic agents, and often cause adverse ...
Nelly Mezzaroba, Sonia Zorzet, Erika Secco, Stefania Biffi, Claudio Tripodo, Marco Calvaruso, Ramiro Mendoza-Maldonado, Sara Capolla, Marilena Granzotto, Ruben Spretz, Gustavo Larsen, Sandra Noriega, Marianna Lucafò, Eduardo Mansilla, Chiara Garrovo, Gustavo H Marín, Gabriele Baj, Valter Gattei, Gabriele Pozzato, Luis Núñez, Paolo Macor   +20 more
doaj   +1 more source

Resolution of Paraneoplastic Cutaneous Angioendotheliomatosis After CAR T‐Cell Therapy in TP53‐Deleted CLL: A Case Report

eJHaem, Volume 7, Issue 4, August 2026.
ABSTRACT Cutaneous manifestations of chronic lymphocytic leukemia (CLL) are heterogeneous and may result from leukemic infiltration, secondary malignancies, infectious complications, or reactive inflammatory processes. Reactive angioendotheliomatosis (RAE) is a rare vascular proliferation that has only infrequently been reported in association with ...
Feras Alfraih, Mostafa F. Mohammed Saleh, David Li, Razan Mohty, Mohamed Kharfan‐Dabaja   +4 more
wiley   +1 more source

Primary identification of compounds targeting hepatitis B virus capsid formation from the FDA approved drugs

Di-san junyi daxue xuebao, 2019
Objective To identify the candidates targeting capsid formation of HBV by screening a FDA approved drug library. Methods SRluc-HBc6 cells, which indicates the formation of HBc dimers by the split luciferase complementation (SLC), were used as the 1st ...
YUAN Yi, LI Zhiying, WEI Xiafe, SHEN Jing, HU Jieli   +4 more
doaj   +1 more source

First‐Line Treatment of IGHV‐Unmutated Chronic Lymphocytic Leukemia: A Network Meta‐Analysis of Targeted and Chemoimmunotherapy Regimens

European Journal of Haematology, Volume 117, Issue 2, Page 375-383, August 2026.
ABSTRACT Immunoglobulin heavy chain variable region‐unmutated (IGHV‐U) chronic lymphocytic leukemia (CLL) represents a biologically aggressive subgroup with limited responsiveness to chemoimmunotherapy (CIT). To clarify the comparative effectiveness of available frontline options, we conducted a comprehensive Bayesian network meta‐analysis of ...
Santino Caserta, Enrica Antonia Martino, Danilo Lofaro, Ernesto Vigna, Antonella Bruzzese, Francesco Mendicino, Maria Eugenia Alvaro, Caterina Labanca, Eugenio Lucia, Virginia Olivito, Nicola Amodio, Fortunato Morabito, Valter Gattei, Massimo Gentile   +13 more
wiley   +1 more source

From Time‐Limited Therapy to Treatment‐Free Observation: The Evolving Role of MRD in CLL Management

European Journal of Haematology, Volume 117, Issue 2, Page 305-319, August 2026.
ABSTRACT The integration of measurable residual disease (MRD) into the management of chronic lymphocytic leukemia (CLL) has emerged as a major advance in risk stratification and trial design, particularly in the context of time‐limited, targeted regimens.
Enrica Antonia Martino, Santino Caserta, Ernesto Vigna, Antonella Bruzzese, Maria Eugenia Alvaro, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Mamdouh Skafi, Valter Gattei, Fortunato Morabito, Massimo Gentile   +13 more
wiley   +1 more source

Obinutuzumab treatment in the elderly patient with chronic lymphocytic leukemia

Clinical Interventions in Aging, 2015
Karen Seiter, Aleksandra Mamorska-DygaDepartment of Medicine, Division of Hematology/Oncology, New York Medical College, Valhalla, NY, USA Abstract: Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in Western countries ...
Seiter K, Mamorska-Dyga A
doaj  

Chlorambucil-Iron Oxide Nanoparticles as a Drug Delivery System for Leukemia Cancer Cells

International Journal of Nanomedicine, 2021
Samer Hasan Hussein-Al-Ali,1,2 Mohd Zobir Hussein,3 Saifullah Bullo,3 Palanisamy Arulselvan4 1Faculty of Pharmacy, Isra University, Amman, 11622, Jordan; 2Department of Chemistry, Faculty of Science, Isra University, Amman, 11622, Jordan; 3Materials ...
Hussein-Al-Ali SH, Hussein MZ, Bullo S, Arulselvan P   +3 more
doaj  

Chlorambucil Conjugated Ugi Dendrimers with PAMAM-NH₂ Core and Evaluation of Their Anticancer Activity

Pharmaceutics, 2019
Herein, a new Ugi multicomponent reaction strategy is described to enhance activity and solubility of the chemotherapeutic drug chlorambucil through its conjugation to poly(amidoamine) (PAMAM-NH2) dendrimers with the simultaneous introduction of lipidic (
Nalin Seixas, Bruno B. Ravanello, Ibrahim Morgan, Goran N. Kaluđerović, Ludger A. Wessjohann   +4 more
doaj   +1 more source