Results 71 to 80 of about 24,793 (292)

Obinutuzumab in hematologic malignancies: Lessons learned to date [PDF]

, 2015
The routine use of anti-CD20 monoclonal antibodies (mAbs) has improved patient outcomes in CD20-positive non-Hodgkin’s lymphoma (NHL) and chronic lymphocytic leukemia (CLL).
Abes, Ahlgrimm, Alduaij, Alduaij, Andrew Davies, Beers, Berinstein, Beum, Beum, Bezombes, Bonavida, Bosch, Bottcher, Brown, Carlotti, Cartron, Cartron, Cartron, Cartron, Cartron, Casulo, Chan, Cheadle, Cheney, Christian Klein, Clynes, Coiffier, Coiffier, Coiffier, Cragg, Cragg, Dalle, Davis, Davis, de Romeuf, Deans, Dornan, Eichhorst, Fabisiewicz, Farag, Ferrara, Ferrara, Flynn, Foran, Forero-Torres, Fowler, Freeman, Freeman, Ghesquieres, Gibiansky, Gilles Salles, Goede, Goede, Goede, Golay, Goldenberg, Guillaume Cartron, Hallek, Hallek, Hamaguchi, Heider, Herter, Herter, Herting, Hiddemann, Hilchey, Hillmen, Hiraga, Honeychurch, Illidge, Ivanov, Jak, Jefferis, Kennedy, Kern, Kim, Klein, Laprevotte, Laurie H. Sehn, Le Garff-Tavernier, Lim, Maloney, Marcus, Masuda, Minard-Colin, Mitrovic, Mizushima, Morschhauser, Morschhauser, Mossner, Muller, Niederfellner, Niwa, Ogura, O’Brien, O’Brien, Patz, Persky, Pfreundschuh, Polyak, Prochazka, Radford, Rawal, Salles, Salles, Salles, Sehn, Sehn, Shibata-Koyama, Shinkawa, Smith, Teeling, Terszowski, Tim Illidge, Tobinai, Uchida, van Oers, Varoczy, Zhang   +118 more
core   +2 more sources

Molecular iodine‐mediated functionalization of α‐Carbonyl Sulfoxonium ylides with Thiocyanates, Xanthates and Dithiocarbamates

European Journal of Organic Chemistry, Accepted Article.
In this work, we present a straightforward, rapid, and cost‐effective protocol for synthesizing three distinct classes of α‐functionalized sulfoxonium ylides—α‐xanthate, α‐thiocyanate, and α‐dithiocarbamate—via molecular iodine‐mediated reactions. This method demonstrates broad substrate tolerance, including heterocycles and steroids, delivering 25 ...
Kauê C. Capellaro, Antonio C. B. Burtoloso   +1 more
wiley   +1 more source

Necrobiotic xanthogranuloma treated with chlorambucil

Dermatology Online Journal, 2006
We report a case of necrobiotic xanthogranuloma that responded to treatment with chlorambucil. A 56-year-old man presented with a 5-year history of multiple, mildly pruritic, brown-to-violaceous plaques with central ulceration and atrophy involving the periorbital area, extremities, and trunk.
Torabian, Sima Z, Fazel, Nasim, Knuttel, Robin   +2 more
openaire   +5 more sources

The Quinoline Photoremovable Group (PPG) Platform—A Medicinal Chemist's Approach for Photocage Development and Applications

Medicinal Research Reviews, EarlyView.
ABSTRACT Photoremovable protecting groups (PPGs) offer a straightforward solution for the temporary inactivation of biologically active substrates and their subsequent controlled release by light irradiation. Their relatively easy design and mode of application have made them useful tools for studying dynamic biological processes in vitro and in vivo ...
Bence Kontra, Zoltán Mucsi, Janez Ilaš, Petra Dunkel   +3 more
wiley   +1 more source

Chronic Lymphocytic Leukemia in Elderly Patients: Own Experience

Львівський клінічний вісник, 2017
Introduction. The annual incidence rate of chronic lymphocytic leukemia (CLL) in Europe is 1­4 per 100 000 population. The disease is more common in older patients.
Vyhovska O., Vyhovska Ya. , Shalay O. , Lukavetskyy L. , Voytsitskyy V. , Shevchenko L., Barilka V. , Maslyak Z.   +7 more
doaj   +1 more source

Hybrid inhibitors of DNA and HDACs remarkably enhance cytotoxicity in leukaemia cells

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Chlorambucil is a nitrogen mustard-based DNA alkylating drug, which is widely used as a front-line treatment of chronic lymphocytic leukaemia (CLL). Despite its widespread application and success for the initial treatment of leukaemia, a majority of ...
Yoojin Song, Sun You Park, Zhexue Wu, Kwang-Hyeon Liu, Young Ho Seo   +4 more
doaj   +1 more source

Front-Line Therapy for Elderly Chronic Lymphocytic Leukemia Patients: Bendamustine Plus Rituximab or Chlorambucil Plus Rituximab? Real-Life Retrospective Multicenter Study in the Lazio Region

Frontiers in Oncology, 2020
Previous studies investigated the efficacy and the safety of bendamustine (B) vs. chlorambucil (Chl) associated with rituximab (R) in fludarabine-ineligible patients with treated and untreated chronic lymphocytic leukemia (CLL).
Francesco Autore, Idanna Innocenti, Francesco Corrente, Maria Ilaria Del Principe, Serena Rosati, Paolo Falcucci, Alberto Fresa, Esmeralda Conte, Maria Assunta Limongiello, Daniela Renzi, Laura De Padua, Alessandro Andriani, Francesco Pisani, Giuseppe Cimino, Agostino Tafuri, Marco Montanaro, Francesca Romana Mauro, Giovanni Del Poeta, Luca Laurenti, Luca Laurenti   +19 more
doaj   +1 more source

Long‐term survival in a dog with suspected primary nodal plasmacytoma treated with surgical excision

Veterinary Record Case Reports, EarlyView.
Abstract An 8‐year‐old Staffordshire bull terrier presented for left submandibular lymphadenopathy. Cytology showed a monomorphic population of mature plasma cells suggestive of plasma cell neoplasia. On physical examination, no other lymphadenomegaly, cutaneous or oral lesions were found.
Celia Figueroa‐González, Jérémy Béguin, Sarah Stewart, Rachel Garty, Alexandra Guillén   +4 more
wiley   +1 more source

Redox-Responsive Heparin–Chlorambucil Conjugate Polymeric Prodrug for Improved Anti-Tumor Activity

Polymers, 2019
Polymeric prodrug-based delivery systems have been extensively studied to find a better solution for the limitations of a single drug and to improve the therapeutic and pharmacodynamics properties of chemotherapeutic agents, which can lead to efficient ...
Abegaz Andrgie, Y. Birhan, T. Mekonnen, Endiries Yibru Hanurry, H. F. Darge, R. Lee, Hsiao-Ying Chou, Hsieh-Chih Tsai   +7 more
semanticscholar   +1 more source

Chemical genetics analysis of an aniline mustard anticancer agent reveals complex I of the electron transport chain as a target [PDF]

, 2011
Supplementary information is available at the Journal of Biological Chemistry website.The antitumor agent 11β (CAS 865070-37-7), consisting of a DNA-damaging aniline mustard linked to an androgen receptor (AR) ligand, is known to form covalent DNA ...
Cossarizza, Das, Estornell, Fang, Fang, Frezza, Hengartner, Hillier, Jakubowski, Kapiszewska, Laurent, Le, Ling, Marquis, Matés, Murphy, Murphy, Nelson-Rees, Nicco, Nowak, Ott, Ozben, Petronilli, Poppe, Powis, Ravid, Robinson, Ruan, Turrens, Wallach-Dayan, Weiss   +30 more
core   +1 more source