Results 71 to 80 of about 19,748 (246)
Advanced Healthcare Materials, Volume 15, Issue 4, 26 January 2026.Polymer‐based drug delivery systems can effectively overcome the limitations of free drugs in terms of solubility, stability, and plasma half‐life, yet their development has traditionally relied on time‐consuming trial‐and‐error approaches. This review highlights recent advances in applying molecular simulation to the design of polymer‐based drug ...
Ping Gao +4 more
wiley +1 more source
242 Pharmacologic tumor PD-L1 depletion with chlorambucil treats ovarian cancer and melanomas in a tumor PD-L1-dependent manner and renders αPD-L1-resistant tumors αPD-L1-sensitive [PDF]
, 2021 Haiyan Bai +12 more
openalex +1 more source
Conjugation of Au Nanoparticles with Chlorambucil for Improved Anticancer Activity [PDF]
, 2016 Gold nanoparticles (AuNPs) of 30–40 nm in size has been prepared using A. hirsutus leaves extract as reducing agent for Au3+ ions under microwave irradiation from 60 to 360 s.
Manjanna, J. +4 more
core +1 more source
Obinutuzumab treatment in the elderly patient with chronic lymphocytic leukemia
Clinical Interventions in Aging, 2015 Karen Seiter, Aleksandra Mamorska-DygaDepartment of Medicine, Division of Hematology/Oncology, New York Medical College, Valhalla, NY, USA Abstract: Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in Western countries ...
Seiter K, Mamorska-Dyga A
doaj
Pharmaceutics, 2019 Herein, a new Ugi multicomponent reaction strategy is described to enhance activity and solubility of the chemotherapeutic drug chlorambucil through its conjugation to poly(amidoamine) (PAMAM-NH2) dendrimers with the simultaneous introduction of lipidic (
Nalin Seixas +4 more
doaj +1 more source
Recent progress in mitochondria-targeted drug and drug-free agents for cancer therapy [PDF]
, 2019 The mitochondrion is a dynamic eukaryotic organelle that controls lethal and vital functions of the cell. Being a critical center of metabolic activities and involved in many diseases, mitochondria have been attracting attention as a potential target for
Jeena, M.T. +3 more
core +1 more source
Recent Advances of In Situ Anticancer Nanomedicine from Enzyme‐Instructed Self‐Assembly
ChemNanoMat, Volume 11, Issue 12, December 2025.This review summarizes advances in enzymatic self‐assemblies for generating in situ anticancer nanomedicine over the past five years. It highlights the unique features of enzyme substrates for in situ anticancer nanomedicine by discussing the representative examples.
Linrui Zou, Meihui Yi, Bing Xu
wiley +1 more source
Cancer Reports, Volume 8, Issue 12, December 2025.ABSTRACT Background Mycosis fungoides (MF) is a type of cutaneous T‐cell lymphoma (CTCL) with slow progression, usually presenting with patches and plaques. The infiltration of histiocytes and eosinophils in skin cancers can mask the underlying condition, posing a diagnostic challenge.
Seyed Mohammad Vahabi +6 more
wiley +1 more source
New developments in the treatment of chronic lymphocytic leukemia: role of obinutuzumab
Therapeutics and Clinical Risk Management, 2015 Arpita Shah Department of Pharmacy, Georgia Regents University Medical Center, Augusta, GA, USA Abstract: Obinutuzumab is a novel glycoengineered type II anti-CD20 monoclonal antibody with a higher affinity for CD20 epitope, enhanced antibody-dependent
Shah A
doaj
Accelerated Chronic Lymphocytic Leukaemia Complicated by Bilateral Pathological Humeral Fractures
eJHaem, Volume 7, Issue 1, February 2026.
Mariyum Khawar +3 more
wiley +1 more source