Results 91 to 100 of about 39,766 (263)

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

Residual Benefits of Poultry Litter Applied by Subsurface Band vs. Surface Broadcast to Cotton

Agronomy
Poultry litter (PL) is known to have residual effects on crop productivity long after applications cease. Whether this advantage is greater if applied by subsurface vs. surface broadcast is unknown.
Haile Tewolde, Thomas R. Way, Normie Buehring, Johnie N. Jenkins   +3 more
doaj   +1 more source

Modificările structural-funcţionale ale aparatului fotosintetic la pomii de măr sub acţiunea factorilor interni şi externi de formare

Agricultural Science, 2013
The purpose of our investigations was to identify the photosynthetic functional peculiarities of apple variety Florina using the fluorometric method and depending on the leave position on the shoot, presence/absence of the photo-assimilating acceptor ...
DRUŢĂ Ala , GAVRILAŞ Tamara , ŞIŞCANU Gh.   +2 more
doaj  

Transcripts of wheat at a target locus on chromosome 6B associated with increased yield, leaf mass and chlorophyll index under combined drought and heat stress. [PDF]

PLoS One, 2020
Schmidt J, Garcia M, Brien C, Kalambettu P, Garnett T, Fleury D, Tricker PJ.   +6 more
europepmc   +1 more source

Species Dynamics and Gene Expression in Algal Polycultures Under Mixotrophic Cultivation in Outdoor Pilot‐Scale Nordic Conditions

Biotechnology and Bioengineering, EarlyView.
These results demonstrate that mixotrophic conditions drive both microbial community shifts and metabolic reprogramming, underscoring the importance of cultivation strategy and polyculture selection for targeted applications such as nutrient recovery and bioproduct generation.
Quyen Nham, Hanna Farnelid, Catherine Legrand, Elin Lindehoff   +3 more
wiley   +1 more source

Quantitative Partitioning of Photoautotrophic and Photoheterotrophic Contributions During Mixotrophic Growth of Scenedesmus obliquus

Biotechnology and Bioengineering, EarlyView.
Carbon and oxygen fluxes during photoautotrophic, photoheterotrophic and mixotrophic growth of Scenedesmus obliquus. ABSTRACT Mixotrophic growth of microalgae involves the simultaneous assimilation of inorganic and organic carbon sources, but the quantitative contributions of photoautotrophic and photoheterotrophic metabolisms remain poorly resolved ...
Solène Jahan, Thibault Combroux, Samy Kemel, Hélène Marec, Mariana Titica, Howard Fallowfield, Jérémy Pruvost, Guillaume Cogne   +7 more
wiley   +1 more source

Vacancy defect‐induced electron homing breaks phosphodiester bonds for RNA depletion‐driven cancer therapy

BMEMat, EarlyView.
Illustration of 5% S‐vacancy Bi2S3 mediated phosphodiester bonds cleavage in RNA of hepatocellular carcinoma cells, which suppressing ERI3 expression, inhibiting cell proliferation and promoting apoptosis. Abstract Genome‐wide hypertranscription is a hallmark of malignant progression.
Chuncheng Yang, Zehao Shen, Guangming Xiang, Zhe Liu, Huaxin Liu, Jiabei Li, Ao Wang, Yelin Wu, Peiran Zhao, Xingwu Jiang, Jinghan Wang, Xiaoqing Jiang, Wenbo Bu   +12 more
wiley   +1 more source

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

Adaptive Genomic Divergence Across Altitudes in Capsella bursa‐pastoris

Biological Diversity, EarlyView.
Genomic divergence was observed between high‐altitude and low‐altitude populations of Capsella bursa‐pastoris in China, consistent with an important role of ecological factors. Candidate adaptive loci associated with enhanced energy metabolism, photoprotection, and growth plasticity under altitudinal stress were identified.
Lu Liu, Jia Li, Xin Liu, Xue‐Jun Ge, Hui‐Run Huang   +4 more
wiley   +1 more source

Comparative Assessment of Landsat‐8 and SPOT‐7 Satellite Data With Field Spectral Measurements for Estimating Plant Diversity in Sandy Grasslands

Biological Diversity, EarlyView.
We compared Landsat‐8 OLI, SPOT, and hyperspectral data for estimating vascular plant diversity in China's Hunshandak Sandland. SPOT data showed the strongest correlation with alpha diversity, followed by hyperspectral data, with Landsat‐8 performing the weakest.
Ying Ye, Jianxiong Lan, Xiaoyue Zhang, Yu Peng   +3 more
wiley   +1 more source