Results 181 to 190 of about 5,773 (216)
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Antithyroid Effect of Chlorpropamide?
Human Toxicology, 19831 The relationship between plasma chlorpropamide concentration and thyroid function was examined in 87 maturity onset diabetic patients receiving chronic therapy. 2 Although plasma chlorpropamide concentration was weakly negatively correlated with serum thyroxine (r= 0.33, P< 0.01) the mean serum thyroxine and thyrotrophin (TSH) were not different
S. McLaren +6 more
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Plasma chlorpropamide: A critical factor in chlorpropamide-alcohol flush
European Journal of Clinical Pharmacology, 1983The chlorpropamide-alcohol flush (CPAF) phenomenon was quantitatively related to blood levels of acetaldehyde and chlorpropamide in 105 Type II diabetics, of whom 74 had not previously taken the drug and 31 were on chronic treatment. Standardized skin temperature recordings were made with a sensitive probe.
Hans Öhlin +4 more
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Chlorpropamide and Angina Pectoris
Annals of Internal Medicine, 1973Excerpt To the editor: Chlorpropamide is useful in diabetes insipidus for reduction of free water clearance (1), but there have also been reports of water intoxication and low-sodium syndromes with...
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Chlorpropamide-Induced Agranulocytosis
JAMA: The Journal of the American Medical Association, 1977AGRANULOCYTOSIS is a rare complication of chlorpropamide (Diabinese) therapy; it usually subsides as the drug is withdrawn. Death from this form of agranulocytosis is rare, with overwhelming infection the usual cause. 1-3 We report a case of spontaneously remitting agranulocytosis.
Stanley C. Tucker +2 more
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Interaction of Rifampin and Chlorpropamide
Chest, 1980A 62-year-old man who had been taking 250 mg of chlorpropamide daily for several years received rifampin concomitantly and had a subsequent increased dosing requirement of chlorpropamide. When rifampin was discontinued several months later, the serum chlorpropamide concentration rose dramatically.
Timothy H. Self, Tandy Morris
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Chlorpropamide in the Management of Diabetes
Archives of Internal Medicine, 1959Chlorpropamide is a new oral antidiabetic agent. Its chemical name isN-propyl-N'-(p-chloro-benzenesulfonyl)urea. The structural formula (Fig. 1) is similar to other sulfonamide derivatives which have been observed to have a blood-sugar-lowering effect.
Teodora M. Eugenio +2 more
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SEVERE CHLORPROPAMIDE TOXICITY
Journal of the American Medical Association, 1960Chlorpropamide (Diabinese) is a potent, orally used, hypoglycemic sulfonylurea derivative that recently has been used in the management of diabetes mellitus. Earlier reports 1 of clinical trials have, in general, mentioned only minimal sideeffects or none at all when the drug is used in recommended therapeutic doses.
Edwin L. Rothfeld +3 more
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CHLORPROPAMIDE‐INDUCED HYPONATRAEMIA
Medical Journal of Australia, 1975A case of hyponatraemia occurring in a 69-year-old diabetic woman taking chlorpropamide is reported. Increasing the dose of chlorpropamide aggravated the hyponatraemia, and the condition corrected itself when the chlorpropamide was withdrawn. It is believed, therefore, that, in the absence of any other cause for the hyponatraemia, chlorpropamide was ...
Arthur Horniblow, Howard J. Peak
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Metabolism of Chlorpropamide [PDF]
Diabetes Care, 1981 Campbell Rk, Hansten Pd
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