Results 181 to 190 of about 21,620 (229)
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Metabolism of chlorpyrifos and chlorpyrifos oxon by human hepatocytes*
Journal of Biochemical and Molecular Toxicology, 2006AbstractThe metabolism of chlorpyrifos (CPS) and chlorpyrifos oxon (CPO) by human hepatocytes and human liver S9 fractions was investigated using LC‐MS/MS. Cytochrome P450 (CYP)‐dependent and phase II‐related products were determined following incubation with CPS and CPO.
Kyoungju, Choi +3 more
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Journal of Molecular Modeling, 2021
A complete mechanism for the •OH-initiated atmospheric decomposition of the pesticides chlorpyrifos and chlorpyrifos-methyl is proposed, incorporating additional studies on the competing reaction with singlet oxygen. The computational study is based on density functional theory (DFT) at the double-hybrid functional level to treat static correlation in ...
Mateus M, Quintano, Willian R, Rocha
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A complete mechanism for the •OH-initiated atmospheric decomposition of the pesticides chlorpyrifos and chlorpyrifos-methyl is proposed, incorporating additional studies on the competing reaction with singlet oxygen. The computational study is based on density functional theory (DFT) at the double-hybrid functional level to treat static correlation in ...
Mateus M, Quintano, Willian R, Rocha
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1995
Chlorpyrifos is a broad-spectrum organophosphorothioate insecticide with a principal mechanism of toxicity by inactivation of acetylcholinesterase at nerve junctions. Unlike certain organochlorine pesticides, chlorpyrifos is relatively nonpersistent (Racke 1993), and its principal degradation products are less toxic than the parent chemical.
M G, Barron, K B, Woodburn
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Chlorpyrifos is a broad-spectrum organophosphorothioate insecticide with a principal mechanism of toxicity by inactivation of acetylcholinesterase at nerve junctions. Unlike certain organochlorine pesticides, chlorpyrifos is relatively nonpersistent (Racke 1993), and its principal degradation products are less toxic than the parent chemical.
M G, Barron, K B, Woodburn
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Chlorpyrifos intoxication in a bull
Journal of the American Veterinary Medical Association, 1986A mature Brangus bull received the recommended dose of chlorpyrifos and became dull and inappetent 3 days later. Clinical findings included weakness, dehydration, rumen stasis, and rumen distention with fluid and gas. Blood cholinesterase activity was 25% of normal.
W K, Scarratt, D J, Blodgett
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EFFECTS OF CHLORPYRIFOS ON A MICROECOSYSTEM
Environmental Toxicology and Chemistry, 1992Abstract A recirculating aquatic microecosystem consisting of three subsystems and with a total volume of 7.5 L was used to study effects of the insecticide chlorpyrifos. The three subsystems represent the trophic levels of primary producers (algae), herbivores (Daphnia magna), and decomposers (bacteria on a sand filter).
Kees Kersting, René van Wijngaarden
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Transformation of chlorpyrifos and chlorpyrifos-methyl in prairie pothole pore waters
Environmental Science: Processes & Impacts, 2016Reduced sulfur species and dissolved organic matter content are significant factors in determining the fate of organophosphate pesticides in prairie pothole pore waters.
Rachel M, Adams +3 more
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Outcome of patients with chlorpyrifos intoxication
Human & Experimental Toxicology, 2020Introduction: There is a paucity of literature analyzing outcome of chlorpyrifos intoxication. Methods: A total of 40 patients with chlorpyrifos intoxication were seen at Chang Gung Memorial Hospital between 2008 and 2017.
H-F Liu +9 more
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Drug Metabolism and Disposition, 2011
Age-dependent chlorpyrifos (CPF) metabolism was quantified by in vitro product formation in human hepatic microsomes (ages 13 days to 75 years) and plasma (ages 3 days to 43 years) with gas chromatography-mass spectrometry. Hepatic CPF cytochrome P450 desulfuration [CPF to chlorpyrifos-oxon (CPF-oxon)] and dearylation (CPF to 3,5,6-trichloro-2 ...
Jordan Ned, Smith +3 more
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Age-dependent chlorpyrifos (CPF) metabolism was quantified by in vitro product formation in human hepatic microsomes (ages 13 days to 75 years) and plasma (ages 3 days to 43 years) with gas chromatography-mass spectrometry. Hepatic CPF cytochrome P450 desulfuration [CPF to chlorpyrifos-oxon (CPF-oxon)] and dearylation (CPF to 3,5,6-trichloro-2 ...
Jordan Ned, Smith +3 more
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Oxidative desulfuration of chlorpyrifos, chlorpyrifos‐methyl, and leptophos by rat brain and liver
Journal of Biochemical Toxicology, 1989AbstractThe oxidative desulfuration of the three phosphorothionate insecticides—chlorpyrifos, chlorpyrifos‐methyl, and leptophos—was studied in rat brain and liver. Hepatic microsomes demonstrated activities of 4–28 nmol/g/min, with male activity 2‐ to 4‐fold higher than female activity.
J E, Chambers, H W, Chambers
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Toxicology and Applied Pharmacology, 2007
Diisopropylfluorophosphate, originally developed as a chemical warfare agent, is structurally similar to nerve agents, and chlorpyrifos has extensive worldwide use as an agricultural pesticide. While inhibition of cholinesterases underlies the acute toxicity of these organophosphates, we previously reported impaired axonal transport in the sciatic ...
Debra A, Gearhart +4 more
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Diisopropylfluorophosphate, originally developed as a chemical warfare agent, is structurally similar to nerve agents, and chlorpyrifos has extensive worldwide use as an agricultural pesticide. While inhibition of cholinesterases underlies the acute toxicity of these organophosphates, we previously reported impaired axonal transport in the sciatic ...
Debra A, Gearhart +4 more
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