Results 191 to 200 of about 10,439,347 (402)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Are Healthcare Choices Predictable? The Impact of Discrete Choice Experiment Designs and Models.

Value in Health, 2019
E. D. de Bekker-Grob, J. Swait, H. Kassahun, M. Bliemer, M. Jonker, J. Veldwijk, Karen Cong, J. Rose, B. Donkers   +8 more
semanticscholar   +1 more source

EFFICIENT VERSUS NON-EFFICIENT STATED CHOICE DESIGNS. A COMPARISON IN A MODE CHOICE CONTEXT [PDF]

This paper evaluates gains in efficiency produced by the use of efficient designs to analyze stated choice (SC) data. Based on a standard experiment used in a previous research, we compare the efficiency of this design with that of the efficient design ...
Ana Isabel Arencibia, Concepción Román, Juan Carlos Martín, Raquel Espino   +3 more
core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Developing a discrete choice experiment in Malawi: eliciting preferences for breast cancer early detection services

Patient Preference and Adherence, 2015
Racquel E Kohler,1 Clara N Lee,2 Satish Gopal,3 Bryce B Reeve,1 Bryan J Weiner,1 Stephanie B Wheeler11Department of Health Policy and Management, Gillings School of Global Public Health, 2Lineberger Comprehensive Cancer Center, University of North ...
Kohler RE, Lee CN, Gopal S, Reeve BB, Weiner BJ, Wheeler SB   +5 more
doaj  

Exploring the Perceived Difficulty and Importance of Lower Limb Physical Activities for People With and Without Osteoarthritis: A Discrete Choice Experiment [PDF]

Andrés Pierobon, W Taylor, Richard J. Siegert, Robin Willink, Kim L. Bennell, Kelli Allen, Jackie L. Whittaker, J Pearson, Margo Norton, Jane Clark, Hilal Ata Tay, D. Schiphof, Ben Darlow   +12 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Climate Information in Retail Investors’ Decision-Making: Evidence From a Choice Experiment

, 2019
A. Bassen, K. Gödker, Florian Lüdeke‐Freund, Josua Oll   +3 more
semanticscholar   +1 more source

Divergent Preferences for HIV Prevention: A Discrete Choice Experiment for Multipurpose HIV Prevention Products in South Africa

Medical decision making, 2018
M. Quaife, R. Eakle, M. C. Cabrera Escobar, P. Vickerman, M. Kilbourne-Brook, Mercy Mvundura, S. Delany-Moretlwe, F. Terris-Prestholt   +7 more
semanticscholar   +1 more source