Results 201 to 210 of about 10,439,347 (402)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Quantum wave–particle superposition in a delayed-choice experiment

Nature Photonics, 2019
Kai Wang, Qian Xu, Shining Zhu, Xiao-song Ma   +3 more
semanticscholar   +1 more source

Additional file 4 of Patient preferences for pancreatic cancer treatment (PERSEUS): a multicenter discrete choice experiment

Marjolein F. Lansbergen, Ian P. Smith, Ernst van Alphen, Simone Augustinus, Ilse J. M. Fransen, Johanna W. Wilmink, Marc G. Besselink, I. Quintus. Molenaar, Marjolein Y V Homs, Ignace H J T de Hingh, Bert A. Bonsing, Judith de Vos – Geelen, Brigitte C. M. Haberkorn, Pauline A J Vissers, Pythia T. Nieuwkerk, Maarten F. Bijlsma, G. Frederix, H W M van Laarhoven   +17 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Environmental Labelling and Consumption Changes: A Food Choice Experiment

Environmental and Resource Economics, 2019
L. Muller, A. Lacroix, B. Ruffieux
semanticscholar   +1 more source

Community preferences for 'mental health insurance coverage in Tehran using a discrete choice experiment. [PDF]

Cost Eff Resour Alloc
Talebianpour H, Daroudi R, Jaafaripooyan E, Sharafi E, Rahmani H.   +4 more
europepmc   +1 more source

Full survey questionnaire and discrete choice experiment materials provided to participants.

Richard Muhindo (7402670), Rachel King (375111), Andrew Mujugira (342653), Whitney Irie (20910783), Patience Muwanguzi (7184522), Flavia Dhikusooka (17509659), Joseph Musaazi (834535), Barbara Castelnuovo (10700)   +7 more
openalex   +1 more source

What Drives Consumer Willingness to Pay for Environmental, Social, and Governance Initiatives? A Choice Experiment [PDF]

Seong Ok Lyu, Changwook Kim
openalex   +1 more source

Modeling ‘No-choice’ Responses in Attribute Based Valuation Surveys [PDF]

We examine the impact of providing a ‘no-choice’ option in an attribute based valuation experiment. The aim of the experiment was to assess monetary values of cockle fishery management practices in the Dutch Wadden Sea for different stakeholder groups ...
Arianne T. de Blaeij, Jeroen C.J.M. van den Bergh, Paulo A.L.D. Nunes   +2 more
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source