Results 241 to 250 of about 401,905 (313)

Treatment preferences of patients with recurrent or metastatic cervical cancer: a discrete choice experiment in the US. [PDF]

Gynecol Oncol Rep
Thaker PH, Lu H, Zhang YJ, Trapali M, Swinburn P, Krucien N, White D, Chaiprasert-Paguio J, Pothuri B, Ting J.   +9 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Nepalese Cancer Patients' Willingness to Pay for Improved Quality of Life: A Choice Experiment Study. [PDF]

Healthcare (Basel)
Shahid A, Bohara A.
europepmc   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

The Influence of Perspective on the Valuation of the EQ-5D-Y-3L: A Comparison Using the OPUF Tool and a Discrete Choice Experiment. [PDF]

Pharmacoeconomics
Hitch J, Kumar G, Schneider P, Devlin N, Shah K, Mott D.   +5 more
europepmc   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

The role of environmental impact in healthcare providers' choices of inhalers for treatment of asthma and COPD: a discrete choice experiment. [PDF]

BMC Prim Care
Arslan IG, Vervloet M, de Bekker-Grob EW, Hek K, Knottnerus BJ, Wagner C, van Eikenhorst L.   +6 more
europepmc   +1 more source

Diagnostic Testing Preferences in Rural and Vulnerable Populations During a Pandemic: Discrete Choice Experiment.

JMIR Public Health Surveill
van den Broek-Altenburg E, Benson J, Jonk Y, Leslie A, Carney J, Stein G.   +5 more
europepmc   +1 more source

Finding the Sweet Spot: Preferences for Effectiveness, Duration, and Side Effects in a Discrete Choice Experiment Among Uganda's Key Populations. [PDF]

Vaccines (Basel)
Ngaybe MGB, Muhumuza R, Antunes M, Musingye E, Joseph KK, Nakaggwa B, Mugamba S, Ssuna B, Valdez G, Ehiri J, Ingram M, Kiragga A, Mirembe G, Mwesigwa B, Kibuuka H, Madhivanan P.   +15 more
europepmc   +1 more source