Results 41 to 50 of about 411,746 (267)

Equity in network design: a latent class choice model for prioritising investment decisions

Transportation Research Interdisciplinary Perspectives
The allocation of resources in transport network investments is central to shaping accessibility, sustainability, and equity within infrastructure systems.
Ali Najmi, S.Travis Waller, Taha H. Rashidi   +2 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Optimizing Dog Rabies Vaccination Services to the Public: A Discrete Choice Experiment in Guangdong, China

Animals, 2023
Vaccination for dogs is essential for controlling rabies and achieving the goal of eliminating dog-mediated rabies globally by 2030. This paper aims to investigate the preferences for public services regarding rabies vaccination, in an effort to optimize
Ruiqi Chen, Yingxin Zeng, Zhile Deng, Hongfu Liu, Manyi Chen, Yaoming Liang   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Data on Europe-wide public preferences for plankton-based ecosystem services and marine biodiversity from a series of deliberative monetary valuation workshopsZenodo

Data in Brief
Our article describes data from a discrete choice experiment conducted within a series of deliberative monetary valuation workshops. The workshops were held across Europe and explored public preferences for plankton-based ecosystem services and marine ...
Gilles Jean-Louis, Julian R. Massenberg, Bartosz Bartkowski   +2 more
doaj   +1 more source

Vaccine eagerness: A new framework to analyse preferences in single profile discrete choice experiments. Application to HPV vaccination decisions among French adolescents

SSM: Population Health, 2022
Background: We previously conducted a single-profile discrete choice experiment to elicit preferences of adolescents around HPV vaccine communication, finding that only half of participants made variable choices (non-uniform respondents) from which ...
Sandra Chyderiotis, Jonathan Sicsic, Nathalie Thilly, Judith E. Mueller, Bonnay Stéphanie, Pulcini Céline, Agrinier Nelly, Fall Estelle, Gilberg Serge, Bruel Sébastien, Partouche Henri, Le Bel Josselin, Rossignol Louise, Ecollan Marie, Pinot Juliette, Tron Arthur, Hagiu Dragos-Paul, Zuo Minghui, Gauchet Aurélie, Bros Julie, Juneau Catherine, Vareilles Gaëlle, Epaulard Olivier, Banaszuk Anne-Sophie, Branchereau Marion, Gagneux-Brunon Amandine, Kalecinski Julie, Jeanleboeuf Florian, Jambon Géraldine, Botelho-Nevers Elisabeth, Lasset Christine, Laetitia Marie Dit Asse, Chevreul Karine, Michel Morgane, Raude Jocelyn, Barret Anne-Sophie, Bonmarin Isabelle, Levy-Bruhl Daniel, Giraudeau Bruno   +38 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Who should be prioritized for renal transplantation?: Analysis of key stakeholder preferences using discrete choice experiments

BMC Nephrology, 2012
Background Policies for allocating deceased donor kidneys have recently shifted from allocation based on Human Leucocyte Antigen (HLA) tissue matching in the UK and USA. Newer allocation algorithms incorporate waiting time as a primary factor, and in the
Clark Michael D, Leech Dennis, Gumber Anil, Moro Domenico, Szczepura Ala, West Nick, Higgins Robert   +6 more
doaj   +1 more source

Parent's preferences for unscheduled paediatric healthcare: A discrete choice experiment

Health Expectations, 2023
Background Unscheduled healthcare is a key component of healthcare delivery and makes up a significant proportion of healthcare access, with children being particularly high users of unscheduled healthcare.
Emma Nicholson, Thérèse McDonnell, Ciara Conlon, Aoife De Brún, Edel Doherty, Eilish McAuliffe   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source