Results 101 to 110 of about 35,575 (190)

Safety of Advanced Combination Treatment With Selective JAK1 Inhibitors and Biological Therapies in Inflammatory Bowel Diseases: A Real World Experience

Alimentary Pharmacology &Therapeutics, Volume 61, Issue 10, Page 1692-1696, May 2025.
This multicenter study evaluates advanced combination treatment (ACT) with selective JAK1 inhibitors and biologics in 18 difficult‐to‐treat IBD patients. It shows that 77% of CD patients and 80% of UC patients achieved steroid‐free clinical remission at 3 months.
Cécile Cussac, Pauline Rivière, Romain Altwegg, Ludovic Caillo, Florian Poullenot, David Laharie, Cyrielle Gilletta, Guillaume Le Cosquer   +7 more
wiley   +1 more source

Medical Management of Chronic Cholestatic Liver Diseases

Canadian Journal of Gastroenterology, 2000
The purpose of the present review is to discuss the diagnosis and management of cholestatic liver diseases. Differential diagnoses to consider are described, including causes of extrahepatic biliary obstruction such as gallstones, strictures ...
Andrea A Gossard, Keith D Lindor
doaj   +1 more source

Diabetes Mellitus in Patients With Autoimmune Hepatitis: Frequency, Risk Factors and Effect on Outcome

Alimentary Pharmacology &Therapeutics, EarlyView.
New‐onset DM occurred in 13% of patients with AIH, was related to older age, non‐Caucasian ethnicity, higher prednisolone dose, higher BMI at diagnosis and weight gain and was an independent predictor of all‐cause death/transplantation and of cirrhosis development, underlining the need to minimise steroid burden in AIH.
Sarah Flatley, Selena Dixon, Eleanor Pilsworth, Asha Dube, Barbara Hoeroldt, Laura Harrison, Dermot Gleeson   +6 more
wiley   +1 more source

IgG4-Related Sclerosing Cholangitis Involving the Intrahepatic Bile Ducts Diagnosed with Liver Biopsy

Case Reports in Pathology, 2018
IgG4-related disease is characterized by lymphoplasmacytic inflammation and fibrosis, often leading to mass-forming lesions in different organs. When IgG4-related disease affects the bile ducts, it is called IgG4-related sclerosing cholangitis. A 74-year-
Malene Theilmann Thinesen, Ove B. Schaffalitzky de Muckadell, Sönke Detlefsen   +2 more
doaj   +1 more source

Biliary Bicarbonate Secretion Constitutes a Protective Mechanism against Bile Acid-Induced Injury in Man [PDF]

, 2011
Background: Cholangiocytes expose a striking resistance against bile acids: while other cell types, such as hepatocytes, are susceptible to bile acid-induced toxicity and apoptosis already at micromolar concentrations, cholangiocytes are continuously ...
Amelsberg A, Batzri S, Beuers U, Beuers U, Douglas M. Jefferson, Duane WC, Eastwood GL, Hofmann AF, Hohenester S, Hov JR, Lucas Maillette de Buy Wenniger, Medina JF, Melero S, Minagawa N, Poupon R, Prieto J, Prieto J, Ronald P. Oude Elferink, Rust C, Simon Hohenester, Spivey JR, Ulrich Beuers   +21 more
core   +1 more source

Endoscopic management of primary sclerosing cholangitis

Digestive Endoscopy, EarlyView.
Primary sclerosing cholangitis (PSC) is a progressive autoimmune hepatobiliary disease characterized by fibrotic strictures in the bile ducts, leading to chronic cholestasis and cirrhosis. Magnetic resonance cholangiopancreatography (MRCP) is a noninvasive method for evaluating the condition of the bile ducts, and has high sensitivity and specificity ...
Suguru Mizuno, Yoshihito Uchida, Satsuki Ando, Masamitsu Nakao, Kayoko Sugawara, Nobuaki Nakayama, Yukinori Imai, Tomoaki Tomiya, Satoshi Mochida   +8 more
wiley   +1 more source

Neonatal cholestasis due to primary sclerosing cholangitis

Journal of Family Medicine and Primary Care, 2016
Neonatal cholestasis is rarely caused due to primary sclerosing cholangitis, which is an inflammatory disease of the bile ducts, which results in obstructive fibrosis of the ducts.
Naman Sadanand Shetty, Ira Shah
doaj   +1 more source

Endoscopic diagnosis of immunoglobulin G4‐related sclerosing cholangitis

Digestive Endoscopy, EarlyView.
Immunoglobulin G4 (IgG4)‐related sclerosing cholangitis (IgG4‐SC) is a distinct form of sclerosing cholangitis frequently associated with autoimmune pancreatitis and is recognized as a biliary manifestation of IgG4‐related disease. Endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasonography (EUS) are key diagnostic modalities ...
Itaru Naitoh, Michihiro Yoshida, Takahiro Nakazawa   +2 more
wiley   +1 more source

Atezolizumab-induced Sclerosing Cholangitis in a patient with lung cancer: A case report

Cancer Treatment and Research Communications, 2021
Atezolizumab is an immune checkpoint inhibitor that is a key drug in non-small-cell lung cancer treatment. However, it can cause immune-related adverse events, including liver injury.
Shinji Nabeshima, Masahiro Yamasaki, Naoko Matsumoto, Shintaro Takaki, Yumi Nishi, Kazuma Kawamoto, Masaya Taniwaki, Nobuyuki Ohashi, Noboru Hattori   +8 more
doaj  

Phenotypic Differences and Clinical Outcomes of South Asian Children With IBD: A Singapore–Malaysia Study From the Asian PIBD Registry Network

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background and Aim Existing literature largely contrasts pediatric inflammatory bowel disease (PIBD) phenotypic differences and outcomes of South Asians (SAs) with Caucasians. No published comparative data exist between SAs and non‐SAs within Asia‐Pacific.
James Guoxian Huang, Kee Seang Chew, Veena Logarajah, Way Seah Lee, Marion Margaret Aw   +4 more
wiley   +1 more source