Results 61 to 70 of about 21,441 (140)

IGFBP4 is a Metric for Primary Biliary Cholangitis and Attenuates Biliary Epithelial Cell Injury

Liver International, Volume 46, Issue 3, March 2026.
ABSTRACT Background and Aims Immune‐mediated bile duct injury is the primary histological feature of autoimmune cholestatic liver diseases. Macrophages, the most abundant immune cell population in the liver, have been postulated to play a critical role in biliary repair. However, it is unclear whether activated macrophages interact with injured biliary
Xing Zhou, Shuyu Shao, Danning Yang, Ziyan Cheng, Toshihiro Tanaka, Patrick S. C. Leung, Koichi Tsuneyama, Aftab A. Ansari, William M. Ridgway, Pietro Invernizzi, Christopher L. Bowlus, M. Eric Gershwin, Weici Zhang   +12 more
wiley   +1 more source

An Atypical Presentation of Lemmel's Syndrome: A Rare Culprit of Intermittent Biliary Obstruction

Clinical Case Reports, Volume 14, Issue 2, February 2026.
Imaging features of Lemmel syndrome illustrating intermittent extrinsic compression of the common bile duct by a periampullary duodenal diverticulum. Current CT demonstrates abrupt CBD tapering with upstream biliary dilatation, while prior imaging shows preserved ductal caliber, supporting a dynamic obstructive process.
Tinsae Anebo, Michael Negussie, Phuuwadith Wattanachayakul, Karecia Byfield, Hamza Tahir, Adrian Zhou, Ghideon Ezaz   +6 more
wiley   +1 more source

Epstein‐Barr Virus Infection at Single‐Cell Resolution

Journal of Medical Virology, Volume 98, Issue 2, February 2026.
ABSTRACT Epstein‐Barr virus (EBV) infection has been studied at single‐cell resolution for six decades and counting. Such investigations can reveal virus‐host interactions and their dependence on viral strain, cellular niche, infection program, immune response regulation, and time.
Elliott D. SoRelle
wiley   +1 more source

Temporal Variability and Influence of Measurement Conditions of AI‐Based Atrial Fibrillation Risk Estimation

Journal of Arrhythmia, Volume 42, Issue 1, February 2026.
The atrial fibrillation (AF) risk estimated by artificial intelligence‐based program installed in electrocardiography (ECG) machine exhibited temporal variability. Reproducibility within one level of error was 100% for the same ECG, 95% for reproducibility within 4 min interval, and 87% for reproducibility over 15 min interval.
Satomi Hamada, Miki Amemiya, Mie Ochida, Susumu Tao, Iwanari Kawamura, Tetsuo Sasano   +5 more
wiley   +1 more source

Vedolizumab for extraintestinal manifestations in pediatric inflammatory bowel disease: Results from the VedoKids study

Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 2, Page 495-502, February 2026.
Abstract Extraintestinal manifestations (EIMs) manifest in 6%‐47% of patients with inflammatory bowel disease (IBD). Here, we characterize the course of EIMs in pediatric patients receiving vedolizumab included in the VedoKids cohort study. This was a subgroup analysis of the pediatric VedoKids cohort, a multicenter, prospective study of children (aged
Giulia D'Arcangelo, Dan Turner, Oren Ledder, Esther Orlanski‐Meyer, Efrat Broide, Maya Granot, Manar Matar, Seamus Hussey, Anat Yerushalmy‐Feler, Christoph Norden, Erasmo Miele, Marina Aloi   +11 more
wiley   +1 more source

Hepatopulmonary syndrome in children and adolescents with portal hypertension in Brazil: A multicenter study

Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 2, Page 366-373, February 2026.
Abstract Objectives To describe the clinical and laboratory characteristics and outcomes of pediatric hepatopulmonary syndrome (HPS) secondary to portal hypertension (PH) in Brazil. Methods Fifty‐four pediatric patients diagnosed with PH and HPS according to the European Respiratory Society criteria were included in this multicenter retrospective study.
Leticia Drumond Alberto, Eleonora Druve Tavares Fagundes, Adriana Teixeira Rodrigues, Thaís Costa Nascentes Queiroz, Gustavo Valverde de Castro, Carlos Oscar Kieling, Sandra Maria Gonçalves Vieira, Natália Lamounier dos Martires Guerra, Natascha Silva Sandy, Gilda Porta, Irene Kazue Miura, Maria Ângela Bellomo Brandão, Gabriel Hessel, Adriana Maria Alves de Tommaso, Alexandre Rodrigues Ferreira   +14 more
wiley   +1 more source

Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Chronic inflammation fuels tumorigenesis via “internal drivers” and “external attractions.” Targeting these core mechanisms with combined therapies/novel deliveries enables precise, potent anti‐inflammatory–antitumor treatment. ABSTRACT Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and ...
Xiaodie Liu, Ziyuan Wang, Huirong Zhu, Yicun Han, Qing Ji   +4 more
wiley   +1 more source

Was Motorized Spiral Enteroscopy Too Risky? A Systematic Review and Meta‐Analysis Including German Registry Data

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background and Study Aims Motorized spiral enteroscopy (MSE) was introduced as a major advancement in small‐bowel enteroscopy, enabling higher complete enteroscopy rates with shorter procedure times. However, after a fatal adverse event (AE) involving severe esophageal injury, the device was withdrawn from the market in July 2023.
Ingo Steinbrück, Armin Kuellmer, Siegbert Faiss, Hendrik Buchholz, Björn Lewerenz, Daniel Fitting, Felix Wiedbrauck, Stephan Hollerbach, Arthur Schmidt, Johannes Wilhelm Rey, Martha M. Kirstein, Franz‐Ludwig Dumoulin, Fabian Maximilian Wittich, Andreas Wannhoff, Jürgen Pohl, Matthias Friesicke, Viktor Rempel, Hans‐Peter Allgaier, Christian Wiessner, Thomas Rösch   +19 more
wiley   +1 more source

Prediction of Hepatocellular Carcinoma and Other Liver‐Related Events in Chronic Hepatitis B Patients With Metabolic Dysfunction or Metabolic Dysfunction‐Associated Steatotic Liver Disease

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 3, Page 374-382, February 2026.
This study evaluated the performance of the PAGE‐B score in HCC risk among CHB patients with metabolic dysfunction or MASLD. The PAGE‐B score effectively stratified HCC risk in both MASLD and non‐MASLD patients, especially in those without cirrhosis, where low scores were linked to negligible 5‐year HCC risk. ABSTRACT Introduction Metabolic dysfunction
Lesley A. Patmore, Ivana Carey, Jordan J. Feld, Willem P. Brouwer, Keyur Patel, Maria Buti, Pieter Honkoop, Douwe F. Postma, Hans Blokzijl, Özgur. M. Koc, Eva van Oorschot, Kosh Agarwal, Marc van der Valk, Faydra I. Lieveld, Mai Kilany, Matthijs Kramer, Joep de Bruijne, Mark A. A. Claassen, Bettina E. Hansen, Robert A. de Man, Harry L. A. Janssen, R. Bart Takkenberg, Milan J. Sonneveld   +22 more
wiley   +1 more source

Non‐Response to Obeticholic Acid Is Associated With Heightened Risks of Developing Clinical Events in Primary Biliary Cholangitis

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 4, Page 494-506, February 2026.
In a multi‐centre study of obeticholic acid in primary biliary cholangitis, 45% discontinued the drug over 4 years, with 11% moving to combination therapy (fibrates). Of those continuing, response rates increased from 37% (1 year) to 55% (4 years). Non‐response at 12 months and cirrhosis were independent predictors of liver‐related events.
Nadir Abbas, Rachel Smith, Ellina Lytvyak, Miki Scaravaglio, Neil Halliday, Amal Almahroos, Nadia Eden, Diane Lloyd‐Madden, Sanchit Sharma, James Ferguson, Jessica K. Dyson, Douglas Thorburn, David Jones, Aldo J. Montano‐Loza, Marco Carbone, Pietro Invernizzi, George Mells, Emma L. Culver, Palak J. Trivedi   +18 more
wiley   +1 more source