Results 81 to 90 of about 51,968 (202)

Endoscopic Visualization of a Jejuno‐Colonic Fistula in a Case of Monomorphic Epitheliotropic Intestinal T‐Cell Lymphoma

DEN Open, Volume 7, Issue 1, April 2027.
Monomorphic epitheliotropic intestinal T‐cell lymphoma (MEITL) rarely presents with gastrointestinal fistula formation. A rare case of MEITL is identified in an elderly woman with marked weight loss and hypoalbuminemia, in whom a jejunocolic fistula is directly visualized endoscopically.
Kanami Ota, Yuichi Matsuno, Yoshiaki Taniguchi, Noriyuki Imazu, Shinichiro Kawatoko, Yutaro Ihara, Tomohiro Nagasue, Keisuke Kawasaki, Tomohiko Moriyama, Junji Umeno   +9 more
wiley   +1 more source

Gallbladder‐Related Adverse Events With Semaglutide 2.4 mg: Pooled Analysis of Placebo‐Controlled STEP Trials

Diabetes, Obesity and Metabolism, EarlyView.
Mika Ukkonen, Antti Kivivuori, Peter Starckjohann, Pekka Lammi, Anna Junttila, Valtteri Panula   +5 more
wiley   +1 more source

Initial Experience With Endoscopic Ultrasound‐Guided Gallbladder Drainage Using Lumen‐apposing Metal Stents in Extremely Elderly and Frail Patients

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Objectives Endoscopic ultrasound‐guided gallbladder drainage (EUS‐GBD) using lumen‐apposing metal stents (LAMS) is a treatment option for acute cholecystitis in high‐risk surgical patients. However, data on extremely elderly and frail patients are limited. We report our initial experience with EUS‐GBD using electrocautery‐enhanced LAMS in this
Kiyoyuki Kobayashi, Takako Nomura, Maki Ayaki, Tomohiro Ogi, Yudai Sato, Manabu Yamada, Daisuke Namima, Naoki Fujita, Hiroki Yamana, Hideki Kamada, Toshiharu Funaki, Akihiro Kondo, Yasuhisa Ando, Hironobu Suto, Minoru Oshima, Keiichi Okano, Hideki Kobara   +16 more
wiley   +1 more source

Gastric Metastasis of Uterine Leiomyosarcoma Detected During Surveillance Endoscopy and Resected by Endoscopic Submucosal Dissection After Multiple Metachronous Metastases: A Case Report

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Uterine leiomyosarcoma (uLMS) is a rare, aggressive uterine malignancy that usually metastasizes hematogenously, whereas gastrointestinal involvement is uncommon. A 69‐year‐old woman with uLMS treated by hysterectomy and adjuvant chemotherapy developed metachronous lung, sigmoid colon, gallbladder, and abdominal wall metastases.
Yuiko Nagasawa, Takahiro Hiratsuka, Daisuke Minezaki, Wataru Miyoshino, Ryo Ogawa, Tomonori Akagi, Hidefumi Shiroshita, Yoshitake Ueda, Kazuhiro Mizukami, Masafumi Inomata   +9 more
wiley   +1 more source

Time to Confirmed Completion of Bowel Preparation as a Preprocedural Indicator of Colonoscope Insertion Difficulty: A Prospective Observational Study

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Background and Aims Runway time, defined as the interval between completion of polyethylene glycol ingestion and the start of colonoscopy, has been studied as a determinant of bowel cleansing quality. However, whether the bowel preparation course itself is associated with colonoscope insertion difficulty remains unclear.
Kazuki Horiuchi, Yusuke Ishibashi, Hiroki Ueda   +2 more
wiley   +1 more source

Cumulative Antigen Suppression Reduces Clonal Plasma Cell Evolution in Gaucher Disease

American Journal of Hematology, Volume 101, Issue 9, Page 2197-2213, September 2026.
ABSTRACT Chronic antigenic stimulation is implicated in the pathogenesis of monoclonal gammopathy and multiple myeloma, yet longitudinal human evidence linking sustained antigen exposure to modifiable clonal plasma cell evolution remains limited. Gaucher disease (GD), caused by biallelic GBA1 pathogenic variants, is characterized by accumulation of ...
Noor Ul Ain, Noffar Bar, Lilu Guo, Katherine Klinger, Punita Gupta, Atta Ur Rahman, Ruhua Yang, Yanhong Deng, Natalia Neparidze, Shiny Nair, Pramod K. Mistry   +10 more
wiley   +1 more source

Application of Virtual Twin PBPK Models in Individuals with Obesity via CYP3A4 Phenotyping Using Endogenous Biomarker Data

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 762-773, September 2026.
Plasma 4β‐hydroxycholesterol (4β‐OHC) normalized for the levels of its parent cholesterol (4β‐OHC/C) is an endogenous biomarker for hepatic CYP3A4. This study evaluated CYP3A4 activity longitudinally in individuals while their obesity status was changing. 4β‐OHC/C was measured pre‐surgery (n = 54) and 2 years after Roux‐en‐Y gastric bypass (n = 30) and
Nihan Izat, Haribhau Kangne, Rasmus Jansson‐Löfmark, Jens K. Hertel, Amin Rostami‐Hodjegan, Ida Robertsen, Aleksandra Galetin   +6 more
wiley   +1 more source

Association between cholecystectomy and the risk of new-onset metabolic dysfunction-associated steatotic liver disease: a risk-stratified cohort study

Scientific Reports
Cholecystectomy has been reported to be associated with an increased risk of metabolic dysfunction-associated steatotic liver disease (MASLD), but the extent and modifying factors of this association remain unclear.
Hong Jae Jeon, Hyuk Soo Eun, Woo Sun Rou, Seok Hyun Kim, Byung Seok Lee, Soon-Ki Ahn   +5 more
doaj   +1 more source

Deferred Cytoreductive Nephrectomy With Partial Hepatectomy for Giant Renal Cell Carcinoma of the Right Kidney With Extensive Hepatic Invasion: A Case Report in the Era of Systemic Immune Checkpoint Inhibitors and Tyrosine Kinase Inhibitors

IJU Case Reports, Volume 9, Issue 5, September 2026.
ABSTRACT Introduction Deferred cytoreductive nephrectomy may improve the prognosis of patients with metastatic renal cell carcinoma (RCC). However, reports of combined hepatic resection for RCC with liver invasion are limited, and treatment strategies remain insufficiently established.
Yuki Hiroshi, Takamitsu Inoue, Takuya Minagawa, Masaki Takahashi, Akinobu Katami, Mizuki Onozawa, Masahiro Shinoda, Osamu Itano, Jun Miyazaki   +8 more
wiley   +1 more source

Prostate Cancer Development, Progression, and Therapy

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin, Zicheng Xiao, Zexian Ding, Wei Li, Ruijiang Zeng, Yujun Shuai, Weimin Ci, Dan Xia, Xu Zhang, Haojie Huang   +9 more
wiley   +1 more source