Results 91 to 100 of about 36,868 (221)

The Lupus Damage Index Revision Program: Results From the Item Generation and Reduction Phases

open access: yesArthritis Care &Research, Volume 78, Issue 10, Page 1449-1466, October 2026.
Objective A data‐driven and expert/patient consensus‐based project to develop a revised Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) is under way supported by SLICC, ACR, and the Lupus Foundation of America. Our objective is to report the item generation and reduction phase results
Burak Kundakci   +25 more
wiley   +1 more source

Gallstone formation and hepatobiliary tumour risk: Clinical implications of the bile acid–gut microbiota axis

open access: yesClinical and Translational Discovery, Volume 6, Issue 5, October 2026.
1. Irregular dietary patterns (e.g., late breakfast, reduced meal frequency) upregulate the bai gene cluster by disrupting cholecystokinin (CCK) release rhythms and gut microbiota circadian rhythms, leading to increased production of secondary bile acids, particularly DCA. High‐carbohydrate dietary patterns increase gallstone risk (OR = 1.329).
Rui Li   +6 more
wiley   +1 more source

Evaluation of progranulin and inflammatory markers in the diagnosis of acute cholecystitis

open access: yesMedicine Science
This study aimed to investigate the role of inflammatory markers and progranulin levels in diagnosing cholecystitis, assessing their potential as diagnostic biomarkers. The research involved 54 patients diagnosed with acute cholecystitis in the emergency
Ali Ihsan Kilci   +5 more
doaj   +1 more source

Long‐Term Safety and Efficacy of Obeticholic Acid in Patients With Primary Biliary Cholangitis: Final Results of the POISE Long‐Term Safety Extension

open access: yesAlimentary Pharmacology &Therapeutics, Volume 64, Issue 8, Page 1083-1096, October 2026.
In the POISE open‐label extension, patients with primary biliary cholangitis with inadequate response or intolerance to ursodeoxycholic acid received long‐term obeticholic acid (OCA) treatment. Findings demonstrated a safety profile consistent with the known characteristics of OCA, with no unexpected safety signals, while supporting sustained efficacy ...
Christopher L. Bowlus   +8 more
wiley   +1 more source

Genetic evidence causally linking gastroesophageal reflux disease to cholecystitis: a two-sample mendelian randomization study

open access: yesBMC Gastroenterology
Background Gastroesophageal reflux disease (GERD) and cholecystitis share overlapping symptoms, including belching, acid reflux, and heartburn. Despite this, the causal relationship between these two conditions remains unclear.
Chao Wang   +3 more
doaj   +1 more source

Artificially Intelligent Simulated Patients in Undergraduate Surgical Teaching: A Single Blinded Randomized Controlled Study

open access: yesThe Clinical Teacher, Volume 23, Issue 5, October 2026.
ABSTRACT Introduction Self‐directed learning (SDL) and reflection are critically important for clinicians. There is limited evidence describing the utilization of artificial intelligence (AI) to support medical SDL. AI simulated patients (AISP) may allow for high‐fidelity, reflective educational interactions.
W. Baraza   +7 more
wiley   +1 more source

Xanthogranulomatous Cholecystitis Cohort Study: A Clinicopathological And Incidental Frequency Analysis

open access: yesPakistan Journal of Medicine and Dentistry
Background: Xanthogranulomatous cholecystitis is a benign, uncommon, localized or diffuse inflammatory pathological condition of the gallbladder and a catastrophic distinct transformation of chronic cholecystitis.
Irum Masood, Ahmed Raheem
doaj  

Derivation and Validation of a Predictive Model for Advanced Colorectal Neoplasia Among Average‐Risk Adults in China

open access: yesInternational Journal of Cancer, Volume 159, Issue 6, Page 1455-1463, 15 September 2026.
Efficient pre‐colonoscopy risk stratification tools are needed, especially in China. Using multicenter colorectal cancer screening data from Shandong Province, the authors developed and validated a risk prediction model for advanced colorectal neoplasia in asymptomatic individuals using sociodemographic characteristics, lifestyle factors, and medical ...
Yan Liu   +6 more
wiley   +1 more source

Short‐Term Outcomes and Cost Drivers of Emergency Surgery for Acute Abdominal Disease in Super‐Elderly Patients: A Study in the Japanese Tertiary Care Hospital

open access: yesAnnals of Gastroenterological Surgery, Volume 10, Issue 5, Page 1486-1495, September 2026.
This retrospective study analyzed patients aged ≥ 85 years undergoing emergency abdominal surgery, focusing on short‐term outcomes and inpatient cost structure under the Japanese DPC system. Although major complications occurred in 19.4% of patients, more than 70% were discharged home.
Yuta Kobayashi   +8 more
wiley   +1 more source

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