Results 111 to 120 of about 120,843 (272)

Fmr1 knockout disrupts multiple intrinsic properties via reduced HCN channel activity in mediodorsal thalamocortical neurons

open access: yesExperimental Physiology, EarlyView.
Abstract The neurodevelopmental disorder fragile X syndrome (FXS) results from hypermethylation of the FMR1 gene, which prevents production of the FMRP protein. FMRP modulates the expression and function of a variety of proteins, including voltage‐gated ion channels, such as hyperpolarization‐activated and cyclic nucleotide‐gated (HCN) channels, which ...
Gregory J. Ordemann   +3 more
wiley   +1 more source

Detection and differentiation of antinuclear antibodies in serum of dengue suspected patients with or without systemic autoimmune disease in Kolkata, India

open access: yesVirulence
The pathophysiology of dengue may be influenced by antibodies released during infection. Several autoimmune diseases are accompanied by antinuclear antibodies (ANAs) but 8–10% of the general population have positive ANA tests. To test the hypothesis that
Rajendra Prasad Chatterjee   +4 more
doaj   +1 more source

Persistence of quantal synaptic vesicle recycling in virtual absence of dynamins

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Figure depicts the key finding from this study. While loss of all dynamins severely debilitates synaptic vesicle retrieval following repetitive activity, retrieval and recycling of individual synaptic vesicles following spontaneous fusion or sparse stimulation are minimally affected.
Olusoji A. T. Afuwape   +4 more
wiley   +1 more source

Evaluating the Potential of ChatGPT to Support Climate Risk and Adaptation Assessment

open access: yesClimate Resilience and Sustainability, Volume 4, Issue 2, December 2025.
Scaling up adaptation is essential for addressing climate risks, but there are no globally applicable, sector‐based inventories of adaptation options. Assistive technologies like ChatGPT can help with the rapid scoping of climate risks, adaptation actions, costs and benefits and flag potential maladaptation. Adaptation measures identified for national (
Robert L. Wilby
wiley   +1 more source

What Does a Climate‐Resilient Rural Water Supply System Look Like? An Interdisciplinary Approach to Climate Resilience Mapping in Nepal

open access: yesClimate Resilience and Sustainability, Volume 4, Issue 2, December 2025.
The climate resilience mapping framework (Lower left) was applied in the hill district of Nepal (upper left) to map Rural Water Supply Systems (right) ABSTRACT Climate change significantly affects the water, sanitation, and hygiene (WASH) services, especially in rural areas of developing countries like Nepal.
Santosh Nepal   +6 more
wiley   +1 more source

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