Results 1 to 10 of about 5,065 (135)

Expression of tumor necrosis factor alpha, interleukin-1 and matrix metalloproteinase-9 and pathomorphological changes in acquired middle ear cholesteatoma [PDF]

Biomedicinska istraživanja, 2021
Introduction. The inflammatory mediators play a central role in the pathogenesis of the inflammatory process of the middle ear and cholesteatoma from the aspect of initiating and maintaining the inflammatory response to infection and lesion.
Dalibor Vranješ, Predrag Špirić, Mirjana Gnjatić   +2 more
doaj   +1 more source

Analysis of mRNA m6A modification and mRNA expression profiles in middle ear cholesteatoma

Frontiers in Genetics, 2023
Introduction: Middle ear cholesteatoma is characterized by the hyperproliferation of keratinocytes. In recent decades, N6-methyladenosine (m6A) modification has been shown to play an essential role in the pathogenesis of many proliferative diseases ...
Shumin Xie, Li Jin, Jun He, Jinfeng Fu, Tuanfang Yin, Jihao Ren, Wei Liu   +6 more
doaj   +1 more source

Microarray analysis and functional prediction of differentially expressed circular RNAs in acquired middle ear cholesteatoma

BioMedical Engineering OnLine, 2021
Background Middle ear cholesteatoma is characterized by hyper-proliferation of keratinocytes. Circular RNA (circRNA) plays an essential role in the pathogenesis of many proliferative diseases.
Shumin Xie, Li Jin, Tuanfang Yin, Jihao Ren, Wei Liu   +4 more
doaj   +1 more source

Classification and Stages of Middle Ear Cholesteatoma at the Southern Philippines Medical Center Using the European Academy of Otology and Neurotology / Japan Otological Society (EAONO / JOS) System

Philippine Journal of Otolaryngology Head and Neck Surgery, 2021
Objective: To determine the stage of middle ear cholesteatoma of patients who underwent middle ear surgery at the Southern Philippines Medical Center from January to December 2019, based on European Academy of Otology and Neurotology / Japan ...
Dominador Toral, Chris Robinson Laganao
doaj   +1 more source

Immunohistochemical localization of d‐β‐aspartic acid in congenital and acquired middle ear cholesteatoma

Laryngoscope Investigative Otolaryngology, 2022
Objective/Hypothesis Middle ear cholesteatoma is characterized by abnormal growth of the keratinizing squamous epithelium of the temporal bone. d‐β‐aspartic acid is the major isomer of d‐aspartic acid found in elderly tissue.
Shiori Kitaya, Ryoukichi Ikeda, Jun Suzuki, Hidetoshi Oshima, Yuri Nomura, Yusuke Kusano, Nobuo Ohta, Tetsuaki Kawase, Kazue Ise, Kazuhiro Murakami, Yasuhiro Nakamura, Hironobu Sasano, Yukio Katori   +12 more
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Research Progress on Non-coding RNAs in Cholesteatoma of the Middle Ear [PDF]

Clinical and Experimental Otorhinolaryngology, 2023
Cholesteatoma of the middle ear is a common disease in otolaryngology that is receiving increasing attention. It is estimated that over five million people around the world have suffered from middle ear cholesteatoma.
Dongliang Liu, Hang Zhang, Xiulan Ma, Yaodong Dong   +3 more
doaj   +1 more source

Value of Endoscopy in Cholesteatoma Clearance: A Systematic Review [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: The primary goal of cholesteatoma surgery is to eradicate it from the middle ear cleft. However, due to linear axis of illumination of the microscope, in some of the recesses or hidden areas in middle ear are not visualised.
Prakash S Handi, Harish Onkarappa Mudhbasalar   +1 more
doaj   +1 more source

Extensive qPCR analysis reveals altered gene expression in middle ear mucosa from cholesteatoma patients

PLoS ONE, 2020
The middle ear is a small and hard to reach compartment, limiting the amount of tissue that can be extracted and the possibilities for studying the molecular mechanisms behind diseases like cholesteatoma.
Cecilia Drakskog, Nele de Klerk, Johanna Westerberg, Elina Mäki-Torkko, Susanna Kumlien Georén, Lars Olaf Cardell, Rafael da Costa Monsanto   +6 more
doaj   +2 more sources

The significance of the expression of cell proliferation and inflammation markers in the development of acquired middle ear cholesteatoma [PDF]

Vojnosanitetski Pregled, 2018
Background/Aim. Permanent proliferation and periodical infection are the main clinical characteristics of acquired middle ear cholesteatoma. The aim of this study was to research immunohistochemical characteristics of the skin along with the ...
Erdoglija Milan, Grgurević Uglješa, Cerović Snežana, Jović Milena, Baletić Nenad, Sotirović Jelena   +5 more
doaj   +1 more source

Transcanal Endoscopic Ear Surgery for Congenital Cholesteatoma [PDF]

Clinical and Experimental Otorhinolaryngology, 2018
Objectives As endoscopic instrumentation, techniques and knowledges have significantly improved recently, endoscopic ear surgery has become increasingly popular. Transcanal endoscopic ear surgery (TEES) can provide better visualization of hidden areas in
Joo Hyun Park, Jungmin Ahn, Il Joon Moon
doaj   +1 more source