Results 71 to 80 of about 61,668 (230)

Stem cells in middle ear cholesteatoma contribute to its pathogenesis

Scientific Reports, 2018
Cholesteatoma is a potentially life-threatening middle ear lesion due to the formation of an inflamed ectopic mass of keratinizing squamous epithelium.
J. Nagel, Saskia Wöllner, M. Schürmann, Viktoria Brotzmann, Janine Müller, J. Greiner, P. Goon, B. Kaltschmidt, C. Kaltschmidt, H. Sudhoff   +9 more
semanticscholar   +1 more source

A Novel Decellularized Fibrocartilage Graft Promotes Tympanic Membrane Repair

Advanced Healthcare Materials, Volume 15, Issue 29, 7 August 2026.
An off‐the‐shelf decellularized porcine meniscus fibrocartilage graft (MEND) is engineered for pediatric tympanoplasty. Featuring a microchannel architecture that promotes host cell invasion, MEND rapidly closes tympanic membrane perforations and fully remodels in vivo, outperforming fascia and matching cartilage grafts while avoiding donor‐site ...
Paul M. Gehret, Ryan M. Friedman, Gautham Nair, Stephanie L. Fung, Dana D. Ragbirsingh, John Germiller, Riccardo Gottardi   +6 more
wiley   +1 more source

Bone Auditory Thresholds Variations in Cholesteatoma Middle Ear Surgery

International Journal of Otolaryngology and Head & Neck Surgery, 2023
Xiongguang Liu, Qing Zhou, Li Yao, Tiantian Tang, Wen Wang   +4 more
semanticscholar   +1 more source

Microarray Analysis of Differentially-expressed MicroRNAs in Acquired Middle Ear Cholesteatoma

International Journal of Medical Sciences, 2018
Objectives: To analyze the miRNAs expression profiling between acquired middle ear cholesteatoma and normal skin, and to identify several novel miRNAs which may be involved in the etiopathogenesis of middle ear cholesteatoma.
S. Xie, Xiao-yong Liu, Zhen Pan, Xing Chen, A. Peng, T. Yin, Jihao Ren, Wei Liu   +7 more
semanticscholar   +1 more source

Sinonasal Inflammatory Burden on Computed Tomography in Adults With Obstructive Eustachian Tube Dysfunction: A Case–Control Study

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 4, August 2026.
ABSTRACT Introduction Chronic rhinosinusitis (CRS) and Eustachian tube dysfunction (ETD) frequently coexist, yet objective data quantifying their relationship remain scarce. Because both conditions can reflect shared mucosal inflammation, we investigated whether adults with objectively verified ETD harbor a larger paranasal sinus inflammatory burden on
Dachan Kim, Jeong Gum Lee, Seong Hoon Bae   +2 more
wiley   +1 more source

Systematic Reanalysis of Whole‐Exome Sequencing in Genetically Unsolved Pediatric Primary Ciliary Dyskinesia

Pediatric Pulmonology, Volume 61, Issue 8, August 2026.
ABSTRACT Background Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder, and despite advances in next‐generation sequencing, a substantial proportion of clinically suspected pediatric cases remain without a molecular diagnosis.
Tilbe Hakçıl Öz, Tuğba Şişmanlar Eyüboğlu, Ayşe Tana Aslan, Nilgün Kula, Gülsüm Kayhan   +4 more
wiley   +1 more source

Expression of periostin in the epithelium of cholesteatoma with different degrees of ossicular chain destruction and its clinical value in predicting postoperative hearing recovery

BioMedical Engineering OnLine
Objectives To explore the expression of periostin in the epithelium of cholesteatoma with different destruction degrees of the ossicular chain and its clinical value in predicting postoperative hearing recovery.
Cuncun Xie, Xiaodong Jia, Shaoguang Ding, Xiaoli Ding, Guangke Wang, Hongjian Liu   +5 more
doaj   +1 more source

Primary Ciliary Dyskinesia: A Suggested Pathway to Transition From Pediatric to Adult Care

Pediatric Pulmonology, Volume 61, Issue 8, August 2026.
ABSTRACT Primary ciliary dyskinesia (PCD) is a rare, genetically heterogeneous disorder characterized by motile ciliary dysfunction that impairs mucociliary clearance. Symptoms of PCD can include unexplained neonatal respiratory issues, chronic sino‐otopulmonary symptoms, recurrent infections, bronchiectasis, and subfertility.
Abel De Castro, Melanie Sue Collins, Raksha Jain, Jennifer B. Walsh, Juliana Alba‐Suárez, Yadira M. Rivera‐Sánchez   +5 more
wiley   +1 more source

Spontaneous external auditory canal cholesteatoma in a young male: Imaging findings and differential diagnoses

Indian Journal of Radiology and Imaging, 2016
A cholesteatoma is a non-neoplastic lesion of the petrous temporal bone commonly described as “skin in the wrong place.” It typically arises within the middle ear cavity, may drain externally via tympanic membrane (mural type), or may originate in the ...
Yashant Aswani, Ravi Varma, Gayathri Achuthan   +2 more
doaj   +1 more source

Expression of Prostaglandin E2 Receptors in Acquired Middle Ear Cholesteatoma

Clinical and Experimental Otorhinolaryngology, 2017
Objectives To investigate the expression of prostaglandin E2 receptor subtypes, E-prostanoid (EP) 1–4 receptors, in acquired cholesteatoma and its possible role in the pathologic process of this disorder. Methods Specimens of human acquired cholesteatoma
Su Wang, Li Xie, Yanfei Zhang, Pengfei Xu, Aiguo Liu   +4 more
semanticscholar   +1 more source