Results 1 to 10 of about 14,421 (165)
Favorable effects of Anethum graveolens on liver oxidative stress and cholesterol 7 alpha-hydroxylase levels in non-alcoholic fatty liver disease (NAFLD) rat models [PDF]
Metabolism Open, 2021 Background: High-fat high-cholesterol diet induces a phenotype similar to non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in humans.
Ebrahim Abbasi +4 more
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Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis [PDF]
Liver Research, 2020 Cholesterol 7 alpha-hydroxylase (CYP7A1, EC1.14) is the first and rate-limiting enzyme in the classic bile acid synthesis pathway. Much progress has been made in understanding the transcriptional regulation of CYP7A1 gene expression and the underlying ...
John Y.L. Chiang, Jessica M. Ferrell
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Measurement of cholesterol 7 alpha-hydroxylase activity with selected ion monitoring.
Journal of Lipid Research, 1981 Formation of 7 alpha-hydroxycholesterol by rat liver microsomes was quantitated using a gas chromatograph-mass spectrometer operated in selected ion monitoring mode.
A Sanghvi +5 more
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Journal of Lipid Research, 1992 Interruption of the enterohepatic circulation by cholestyramine causes a several-fold increase in bile acid synthesis, reflected in a stimulation of cholesterol 7 alpha-hydroxylase activity; the synthesis of cholic acid being stimulated to a greater ...
K Einarsson +3 more
doaj +4 more sources
Journal of Lipid Research, 1993 Cholesterol 7 alpha-hydroxylase, the rate-determining enzyme in the bile acid biosynthesis pathway, is regulated in a negative feedback manner by hydrophobic bile salts returning to the liver via the portal circulation.
MP Jones +5 more
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Expression and purification of human cholesterol 7 alpha-hydroxylase in Escherichia coli.
Journal of Lipid Research, 1994 Cholesterol 7 alpha-hydroxylase (P450c7) is the first and rate-limiting enzyme in bile acid biosynthesis and is the product of a cytochrome P450 gene, CYP7.
W G Karam, J Y Chiang
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On the saturation of the cholesterol 7 alpha-hydroxylase in human liver microsomes.
Journal of Lipid Research, 1989 The relationships between cholesterol 7 alpha-hydroxylase activity, pool of free microsomal cholesterol, and degree of substrate saturation of the enzyme were studied in untreated (n = 5), cholesterol-fed (n = 4), and cholestyramine-treated (n = 6 ...
K Einarsson, E Reihnér, I Björkhem
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Journal of Lipid Research, 1993 Compared to BALB/c mice, inbred C57BL/6 mice are more susceptible to developing fatty streak atherosclerotic lesions when fed a cholesterol-rich diet containing taurocholate. We examined the metabolic basis for the taurocholate requirement.
S Dueland +5 more
doaj +4 more sources
Thyroid hormone induction of human cholesterol 7 alpha-hydroxylase (Cyp7a1) in vitro. [PDF]
Mol Cell Endocrinol, 2014 Thyroid hormone (TH) modulates serum cholesterol by acting on TH receptor β1 (TRβ1) in liver to regulate metabolic gene sets. In rodents, one important TH regulated step involves induction of Cyp7a1, an enzyme in the cytochrome P450 family, which enhances cholesterol to bile acid conversion and plays a crucial role in regulation of serum cholesterol ...
Lammel Lindemann JA +4 more
europepmc +4 more sources
Journal of Lipid Research, 1995 Inhibitors of protein kinases were screened for the ability to prevent the repression of cholesterol 7 alpha-hydroxylase mRNA by taurocholate in primary cultures of adult rat hepatocytes.
R T Stravitz +3 more
doaj +2 more sources