Results 11 to 20 of about 14,466 (210)

Studies on the regulation of cholesterol 7 alpha-hydroxylase and HMG-CoA reductase in rat liver: effects of lymphatic drainage and ligation of the lymph duct.

Journal of Lipid Research, 1990
Lymphatic drainage leads to a significant stimulation of both the cholesterol 7 alpha-hydroxylase and HMG-CoA reductase activity in rats (Björkhem et al. 1978. Biochem. Biophys. Res. Commun. 85: (532-540).
JE Akerlund, I Björkhem
doaj   +2 more sources

On the possible use of the serum level of 7 alpha-hydroxycholesterol as a marker for increased activity of the cholesterol 7 alpha-hydroxylase in humans

Journal of Lipid Research, 1987
The possibility was investigated that the serum level of 7 alpha-hydroxycholesterol can be used as a marker for cholesterol 7 alpha-hydroxylase activity. Six patients with gallstone disease were found to have a mean level of 7 alpha-hydroxycholesterol in
I Björkhem, E Reihnér, B Angelin, S Ewerth, J E Akerlund, K Einarsson   +5 more
doaj   +2 more sources

Partial Cloning of cDNA for Hamster Liver Cholesterol 7.ALPHA.-Hydroxylase.

Internal Medicine, 1993
A partial cDNA clone encoding cholesterol 7 alpha-hydroxylase (pHA 7 alpha-3) was isolated from a hamster liver cDNA library using rat P-450 ch7 cDNA (p 7 alpha-11) as a probe. In comparison with the complete base sequence of p 7 alpha-11, pHA 7 alpha-3 lacked about 500 base pairs at the 5' end.
Kozo HAYASHI, Hitoshi KURUSHIMA, Masayumi SAEKI, Hiroshi AMIOKA, Jun-ichi KUROKAWA, Yoshio KUGH, Shuichi NOMURA, Yoshifumi OHKURA, Harumi OHTANI, Mitsuhide NOSHIRO, Goro KAJIYAMA   +10 more
openaire   +4 more sources

Regulation of cholesterol 7 alpha-hydroxylase expression by sterols in primary rat hepatocyte cultures.

Journal of Lipid Research, 1995
The importance of cholesterol and “oxysterols” in the regulation of cholesterol 7 alpha-hydroxylase is not clear. Previous in vivo studies suggest that cholesterol may up-regulate cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid ...
K.C. Doerner, E.C. Gurley, Z.R. Vlahcevic, P.B. Hylemon   +3 more
doaj   +2 more sources

The pool of free cholesterol is not of major importance for regulation of the cholesterol 7 alpha-hydroxylase activity in rat liver microsomes.

Journal of Lipid Research, 1987
The relationship between the cholesterol 7 alpha-hydroxylase activity and the pool of free cholesterol in rat liver microsomes was studied under experimental conditions aimed to stimulate (biliary drainage, cholestyramine treatment, and lymphatic ...
K Einarsson, J E Akerlund, I Björkhem
doaj   +2 more sources

Purification and characterization of cholesterol 7 alpha-hydroxylase from rat liver microsomes.

Journal of Biological Chemistry, 1987
Cholesterol 7 alpha-hydroxylase (cholesterol, NADPH: oxygen oxidoreductase, 7 alpha-hydroxylating, EC 1.14.13.17) was purified from liver microsomes of cholestryramine-fed male rats by using high-performance ion-exchange chromatography. The purified enzyme showed a single band on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (Mr = 52,000 ...
T, Ogishima, S, Deguchi, K, Okuda
openaire   +3 more sources

Cholesterol 7 alpha-hydroxylase (CYP7A1) gene polymorphisms are associated with increased LDL-cholesterol levels and the incidence of subclinical atherosclerosis [PDF]

Biomolecules & Biomedicine
The cholesterol 7 alpha-hydroxylase (CYP7A1) enzyme plays an important role in the conversion of cholesterol to bile acid, contributing to the reduction of cholesterol plasma levels in normal conditions.
Gilberto Vargas-Alarcón, Rosalinda Posadas-Sánchez, Oscar Peréz-Méndez, José Manuel Fragoso   +3 more
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Regulation of rat liver microsomal cholesterol 7 alpha-hydroxylase: presence of a cytosolic activator.

Journal of Lipid Research, 1981
Microsomal cholesterol 7 alpha-hydroxylase (EC 1.14.13.7) in rat liver was assayed by a single-isotope-incorporation method, and factors influencing its activity were studied. Crude cytosol contained a non-catalytic activator which was heat-stable and on-
C T Kwok, W Burnett, I R Hardie
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Hormonal regulation of the cholesterol 7 alpha-hydroxylase gene (CYP7)

Journal of Lipid Research, 1995
The transcriptional regulation of the rat cholesterol 7 alpha-hydroxylase gene (CYP7) by hormones and signal transduction pathways was studied by transient transfection assay of the promoter activity. HepG2 cells were transfected with deletion mutants of
M Crestani, D Stroup, J Y Chiang
doaj   +4 more sources

Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene (CYP7A) in HepG2 cells

Journal of Lipid Research, 1996
A stable HepG2 cell line harboring a human cholesterol 7 alpha-hydroxylase (CYP7A) minigene/luciferase reporter gene construct was selected for studying transcriptional regulation of CYP7A gene promoter.
D P Wang, D Stroup, M Marrapodi, M Crestani, G Galli, J Y Chiang   +5 more
doaj   +2 more sources