Results 21 to 30 of about 14,466 (210)

Bile acid excretion and cholesterol 7 alpha-hydroxylase expression in hypercholesterolemia-resistant rabbits

Journal of Lipid Research, 1993
We have developed a partially inbred substrain of New Zealand white rabbits (CRT/mlo) that are resistant to the hypercholesterolemia that accompanies cholesterol feeding to normal rabbits.
JA Poorman, RA Buck, SA Smith, ML Overturf, DS Loose-Mitchell   +4 more
doaj   +3 more sources

Rat liver cholesterol 7 alpha-hydroxylase. Pretranslational regulation for circadian rhythm.

Journal of Biological Chemistry, 1990
A complete cDNA encoding cholesterol 7 alpha-monooxygenase (EC 1.14.13.17) which had been isolated from rat liver cDNA libraries by using specific antibodies to the enzyme (Noshiro, M., Nishimoto, M., and Okuda, K. (1989) FEBS Lett. 257, 97-100) was totally sequenced.
M, Noshiro, M, Nishimoto, K, Okuda
openaire   +3 more sources

Studies on the link between HMG-CoA reductase and cholesterol 7 alpha-hydroxylase in lymph-fistula rats: evidence for both transcriptional and post-transcriptional mechanisms for down-regulation of the two enzymes by bile acids

Journal of Lipid Research, 1993
The mechanism of down-regulation of hepatic HMG-CoA reductase and cholesterol 7 alpha-hydroxylase by cholic acid (CA) and chenodeoxycholic acid (CDCA) was investigated in rats with a lymph fistula.
I Björkhem, U Andersson, E Sudjama-Sugiaman, G Eggertsen, P Hylemon   +4 more
doaj   +2 more sources

Synchronous circadian rhythms of mRNA levels and activities of cholesterol 7 alpha-hydroxylase in the rabbit and rat.

Journal of Lipid Research, 1995
Cholesterol 7 alpha-hydroxylase, the key enzyme in a series of metabolic changes for the production of bile acids from cholesterol, shows circadian rhythms.
M Kai, T Eto, K Kondo, Y Setoguchi, S Higashi, Y Maeda, T Setoguchi   +6 more
doaj   +2 more sources

Cholesterol 7 alpha-hydroxylase from human liver: partial purification and reconstruction into defined phospholipid-cholesterol vesicles.

Journal of Lipid Research, 1981
Cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme for bile acid synthesis, was shown to be copurified with human liver microsomal cytochrome P-450.
S K Erickson, B Bösterling
doaj   +3 more sources

Dietary fats modulate the regulatory potential of dietary cholesterol on cholesterol 7 alpha-hydroxylase gene expression

Journal of Lipid Research, 1997
Cholesterol 7 alpha-hydroxylase (cyp7) is the rate-limiting enzyme in bile acid biosynthesis. Previously, dietary cholesterol was shown to induce cyp7 gene expression. However, recent studies have produced data that are inconsistent with this observation,
S K Cheema, D Cikaluk, L B Agellon
doaj   +3 more sources

Age-Related Change in the Cholesterol 7α-Hydroxylase Activity in SHRSP

Japanese Heart Journal, 1992
Hiroshi Ogawa, Tomoyo Tanaka, Sukenari Sasagawa   +2 more
openaire   +3 more sources

Oxysterol 7α-Hydroxylase Activity by Cholesterol 7α-Hydroxylase (CYP7A) [PDF]

Journal of Biological Chemistry, 2000
A 7 alpha-hydroxylation is necessary for conversion of both cholesterol and 27-hydroxycholesterol into bile acids. According to current theories, cholesterol 7 alpha-hydroxylase (CYP7A) is responsible for the former and oxysterol 7 alpha-hydroxylase (CYP7B) for the latter reaction.
M, Norlin, U, Andersson, I, Björkhem, K, Wikvall   +3 more
openaire   +2 more sources

Differing effects of cholesterol and taurocholate on steady state hepatic HMG-CoA reductase and cholesterol 7 alpha-hydroxylase activities and mRNA levels in the rat.

Journal of Lipid Research, 1992
We investigated the effects of cholesterol, cholestyramine, and taurocholate feeding on steady state specific activities and mRNA levels of hepatic 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase and cholesterol 7 alpha-hydroxylase in the rat ...
S Shefer, L B Nguyen, G Salen, G C Ness, I R Chowdhary, S Lerner, A K Batta, G S Tint   +7 more
doaj   +1 more source

Bile acid synthesis. VI. Regulation of cholesterol 7 alpha-hydroxylase by taurocholate and mevalonate.

Journal of Lipid Research, 1992
Taurocholate, a relatively hydrophobic bile salt, is a potent down-regulator of HMG-CoA reductase and cholesterol 7 alpha-hydroxylase (C7 alpha H), the rate-determining enzymes of the cholesterol and bile acid biosynthetic pathways, respectively ...
WM Pandak, ZR Vlahcevic, JY Chiang, DM Heuman, PB Hylemon   +4 more
doaj   +1 more source