Results 181 to 190 of about 53,010 (291)

Exosome-mediated cholesterol flow drives scoliosis progression via promoting the spinal cartilage-bone positive feedback. [PDF]

Commun Biol
Zuo M, Xu H, Yang Y, Wang W, Zhou J, Li G, Zhao J, Liu R, Chen H, Wang H.   +9 more
europepmc   +1 more source

Oxygen‐independent expression of HIF‐1α during the cell cycle in hepatocellular carcinoma cells controls essential metabolic pathways under normoxia

The FEBS Journal, EarlyView.
In Huh7 cells, HIF‐1α is essential as it maintains the expression of proteins involved in glycolysis and steroid/cholesterol biosynthesis both under normoxia and hypoxia. On the other hand, in HeLa cells, these pathways are induced by HIF‐1α only under hypoxia.
Ioanna‐Maria Gkotinakou, Christina Arseni, Kreon Koukoulas, Martina Samiotaki, George Panayotou, George Simos, Ilias Mylonis   +6 more
wiley   +1 more source

Editorial: Proteomics in atherosclerosis. [PDF]

Front Cardiovasc Med
Yuan XM, Singh SA.
europepmc   +1 more source

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

The FEBS Journal, EarlyView.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump, Leja Perne, Špela Koren, Eva Jarc Jovičić, Nastja Feguš, Carina Pinto Kozmus, Michele Wölk, Kristyna Brejchova, Maria Fedorova, Ondrej Kuda, Toni Petan   +10 more
wiley   +1 more source

Comparative Effectiveness of Cholesteryl Ester Transfer Protein (CETP) Inhibitors on Lipid Profiles in Adults With Hyperlipidemia: A Comprehensive Systematic Review and Frequentist Network Meta-Analysis of Randomized Controlled Trials. [PDF]

Clin Cardiol
Khalil I, Islam MR, Promi SA, Joy AD, Sayed MA, Acharjee D, Al-Shammari AS, Abrar S, Jamil TB, Taseen M, Biswas S, Mifty SK, Al-Badri SG, Debnath A, Hossain MI, Akter M.   +15 more
europepmc   +1 more source

1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty

The FEBS Journal, EarlyView.
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah, Grace Filbertine, Lucy Gill, Asangaedem Akpan, Marie M. Phelan, Helen Louise Wright   +5 more
wiley   +1 more source

Towards an integrated molecular understanding of plant hormones

Journal of Integrative Plant Biology, EarlyView.
This review offers a comprehensive overview of the nine plant hormones, delving into their biosynthesis, transport, signaling and crosstalk mechanisms. Because the complexity of plant hormonal control goes beyond these core elements, additional specific features are discussed. Lastly, this review highlights how fundamental insights drive hormonal‐based
Louise Vilain, Marie‐Laure Fauconnier, Manon Genva   +2 more
wiley   +1 more source

Dysfunction of the ABCA1 and ABCG1 Transporters and Their Impact on HDL Metabolism. [PDF]

Antioxidants (Basel)
Laguna-Maldonado KD, Uribe-Ramírez D, Vázquez-Carrada M, Matuz-Mares D, Vilchis-Landeros MM.   +4 more
europepmc   +1 more source

Extrusion and Pancreatin Superdosing Modulate the Metabolic Impact of 20% Chlorella vulgaris Inclusion in Broiler Diets

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Microalgae such as Chlorella vulgaris are gaining attention as sustainable and nutritionally valuable feed ingredients, with the potential to partially replace soybean meal in broiler diets. However, dietary inclusion of 20% C. vulgaris has been attempted, but negatively affected growth performance due to limited digestibility.
Ana Rita Mendes, Cátia Falcão Martins, Maria Pinheiro Spínola, Daniela Filipa Pires Carvalho, Obete Madacussengua, Joana Inês Ferreira, Ana Maria Fontes, Rui Manuel Amaro Pinto, Miguel Pedro Mourato, Adam Davis, André Martinho de Almeida, Madalena Lordelo, José António Mestre Prates   +12 more
wiley   +1 more source

Cholesterol-lowering drug targets reduce risk of dementia: Mendelian randomization and meta-analyses of 1 million individuals. [PDF]

Alzheimers Dement
Nordestgaard LT, Hanson A, Sanderson E, Anderson E, Walker V, Tybjærg-Hansen A, Smith GD, Nordestgaard BG.   +7 more
europepmc   +1 more source