Results 291 to 300 of about 51,688 (341)
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The effects of cholinergic agents upon fixated behavior
Psychopharmacologia, 1971A group of male albino rats were subjected to the Maier paradigm (insoluble problem followed by a soluble problem) using the Lashley jumping stand. Forty-two animals which failed the soluble problem by adopting a position stereotype were then randomly assigned to eight drug groups in a 2×2 design.
V P, Houser, R S, Feldman
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The alteration of aversive thresholds with cholinergic and adrenergic agents
Pharmacology Biochemistry and Behavior, 1973Abstract Several cholinergic and adrenergic agents were administered to five squirrel monkeys in a titration schedule to ascertain their effects upon aversive thresholds. A narcotic analgesic, morphine sulfate, in several doses was able to reliably increase the aversive threshold.
V P, Houser, F L, Houser
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Effect of cholinergic agents in Huntington's disease
Neurology, 1983The effects of centrally and peripherally active anti-cholinergic agents were investigated in four patients with Huntington's disease. Scopolamine reduced chorea, increased incoordination, induced sedation, and produced confusion. Benztropine produced similar but milder effects. A peripheral anticholinergic, glycopyrrolate, had no effect. These results,
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Influence of a cholinergic agent, oxotremorine, on sympathetic reflexes
European Journal of Pharmacology, 1978Administration of cholinergic substances by various routes has been reported to produce marked cardiovascular effects. The present study examined the influence of a muscarinic agonist, oxotremorine, on aspects of sympathetic function. The compound reduced blood pressure and spontaneous sympathetic outflow in anesthetized cats after blockade of ...
T, Baum, A T, Shropshire
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1997
Summary Muscarinic receptors play an obvious and important role in the parasympathetically mediated regulation of the internal environment. The muscarinic receptors exist in three pharmacologically defined forms (M1–M3) in contrast to the larger number of subtypes (m1–m5) determined by the techniques of molecular biology.
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Summary Muscarinic receptors play an obvious and important role in the parasympathetically mediated regulation of the internal environment. The muscarinic receptors exist in three pharmacologically defined forms (M1–M3) in contrast to the larger number of subtypes (m1–m5) determined by the techniques of molecular biology.
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Anti‐amyloidogenic activity of cholinergic agents
Drug Development Research, 2002AbstractOverproduction of the peptide amyloid β (Aβ) is thought to be a critical pathogenic event in Alzheimer's disease (AD), leading to the formation of senile (amyloid) plaques, which in turn lead to neurofibrillary tangles, neuronal and synaptic loss, and dementia.
Thomas G. Beach +3 more
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Seizure-related brain damage induced by cholinergic agents
Nature, 1983Distinctive acute brain damage involving limbic and related brain regions develops in adult rats following sustained limbic seizures induced by systemic administration of kainic acid or dipiperidinoethane (DPE) or by intra-amygdaloid injection of kainic acid or folic acid.
J W, Olney, T, de Gubareff, J, Labruyere
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Non-cholinergic intervention of sarin nerve agent poisoning
Toxicology, 2012The protective effects of selected anesthetic regimens on sarin (GB) were investigated in domestic swine. At 30% oxygen, the toxicity of this agent in isoflurane anesthetized animals (LD(50)=10.1μg/kg) was similar to literature sited values in awake swine (LD(50)=11.8μg/kg) and slightly higher than that of both ketamine (LD(50)=15.6μg/kg) and propofol (
Thomas W, Sawyer +4 more
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Methacholine, a cholinergic agent, stimulates catecholamine release in man
Acta Endocrinologica, 1981Abstract. To study the effect of cholinergic stimulation on catecholamine release, methacholine, a choline ester, was injected im into normal subjects. Significant increases in plasma norpinephrine and plasma epinephrine concentrations were observed in response to methacholine administration with significant haemodynamic changes, but there was no ...
S, Hata, S, Shigetomi, S, Fukuchi
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Catecholaminergic and cholinergic agents and duration regulation of ICSS in the rat
Pharmacology Biochemistry and Behavior, 1979Abstract ICSS in the diencephalon and midbrain was measured in a preferred duration situation as a function of pulse frequency and various pharmacological agents. Response measures were ON Time, the mean time ICSS was maintained; OFF Time, the mean time between the offset of a train and the initiation of the next; the log-log slopes of these two ...
M, Edwards, J, Wishik, H M, Sinnamon
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