Results 101 to 110 of about 265,373 (265)

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Mechanism study of an articular cartilage repair material and its forward‐looking test for space medicine

BMEMat, EarlyView.
The regeneration process following dLhCG engraftment progressed through four distinct and interconnected stages. dLhCG maintained its regenerative efficacy after 6 months of cosmic exposure, supporting its potential application in space medicine.
Xu Hu, Hang Yao, Zhen Zhang, Zhonglian Wu, Huiqun Zhou, Bangheng Liu, Liang Ma, Yulei Mu, Dong‐An Wang   +8 more
wiley   +1 more source

THE EFFECT OF EXOGENOUS GLUCOSAMINE HYDROCHLORIDE AND CHONDROITIN SULFATE ON THE SYNTHESIS OF NUCLEIC ACIDS IN PERIODONTAL TISSUES DURING EXPERIMENTAL INFLAMMATION

Кубанский научный медицинский вестник, 2017
The article discusses the study of effect of exogenous glucosamine hydrochloride and chondroitin sulfate on the synthesis of nucleic acids in experimental gingivitis.
N. I. BYKOVA, A. V. ODOLSKI, V. A. GRIGORYAN   +2 more
doaj   +1 more source

Harnessing bacterial extracellular vesicles for bone and cartilage organoids

BMEMat, EarlyView.
This review presents bacterial extracellular vesicles (BEVs) as programmable bioactive regulators for bone and cartilage organoids by delivering functional cargos that modulate skeletal remodeling. It highlights key engineering strategies and future directions to advance next‐generation organoid models for bone aging related diseases.
Han Liu, Xukun Lv, Ting Cheng, Lei Yan, Yuxiao Lai, Keying Guo, Yingying Jing, Hao Shen, Jiacan Su   +8 more
wiley   +1 more source

Comparison between dispersive hidroxypropylmethylcellulose and sodium hyaluronate in phacoemulsification: a systematic review and meta-analysis [PDF]

Revista Brasileira de Oftalmologia
Background: There is a debate regarding the differences in intraocular pressure values between different types of dispersive ophthalmic viscosurgical devices in patients after phacoemulsification for cataracts.
Francisco Victor Carvalho Barroso, Dillan Cunha Amaral, Samuel Montenegro Pereira, David Rocha Lucena, Ricardo Noguera Louzada   +4 more
doaj   +1 more source

Preparation and Biological Activity of N-Sulfated Chondroitin and Dermatan Sulfate Derivatives

, 1996
Carbohydrate Research, 290, 87-96Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY.
VanGorp, C.L., Caldwell, E.E.O., Hansen, K.P., Linhardt, Robert J., Weiler, J.M., Toida, T., Schubert, R.L., Nadkarni, V.D.   +7 more
core   +1 more source

Engineering programmable peptide hydrogels for chronic refractory wounds: A mechanism‐driven framework

BMEMat, EarlyView.
To break the self‐perpetuating pathology of chronic wounds, we propose a mechanism‐driven engineering framework for peptide‐based hydrogels. This review elucidates a hierarchical strategy—from molecular design to intelligent, multi‐functional systems—that enables these programmable biomaterials to dynamically intervene in key pathological loops and ...
Xiaoyu Lv, Xinyi Chao, Jiamin Zhang, Jianfeng Liu   +3 more
wiley   +1 more source

Changes in synovial fluid biomarkers and clinical efficacy of intra‐articular injections of hyaluronic acid for patients with knee osteoarthritis

Journal of Experimental Orthopaedics, 2014
Background The changes in synovial fluid biomarkers after intra‐articular injection of hyarulonic acid (IA HA) remain controversial. We investigate the changes in the properties of synovial fluid (SF) and clinical symptoms before the first and fifth IA ...
Yoshihiro Kusayama, Yasushi Akamatsu, Ken Kumagai, Hideo Kobayashi, Masato Aratake, Tomoyuki Saito   +5 more
doaj   +1 more source

Metabolic Fate of Partially Depolymerized Shark Chondroitin Sulfate in Man

, 1993
Chondroitin sulfates and other glycosaminoglycans are administered as drugs to man by intravenous, intramuscular or oral routes. There are some studies on the pharmacokinetics of heparin, heparan sulfate and dermatan sulfate, whereas few data are ...
G. RONCA, CONTE, Angela
core