Results 221 to 230 of about 250,109 (264)

Glucosamine and Chondroitin Sulfate

Rheumatic Disease Clinics of North America, 2011
Glucosamine and chondroitin sulfate, components of normal cartilage that are marketed as dietary supplements in the United States, have been evaluated for their potential role in the treatment of osteoarthritis. Due to claims of efficacy, increased prevalence of osteoarthritis, and a lack of other effective therapies, there has been substantial ...
Karla L, Miller, Daniel O, Clegg
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The biosynthesis of chondroitin sulfate

Archives of Biochemistry and Biophysics, 1966
Abstract A particulate enzyme preparation from embryonic chick cartilage catalyzes incorporation of radioactivity from UDP-GalNAc- 3 H or UDP-Glc-UA- 14 C into chondroitin sulfate. In the absence of added oligosaccharide acceptor, incorporation of radioactivity from either nucleotide required the presence of the alternate unlabeled nucleotide ...
A, Telser, H C, Robinson, A, Dorfman
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Structure of Chondroitin Sulfate

2006
Publisher Summary This chapter presents the up‐to‐date information on the structure of chondroitin sulfate (CS) and dermatan sulfate (DS). CS is an anionic linear polysaccharide, which is synthesized as part of proteoglycan (PG) molecules in vertebrates and invertebrates.
Fotini N, Lamari, Nikos K, Karamanos
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Synthesis of Chondroitin Sulfate Oligosaccharides and Chondroitin Sulfate Glycopeptides

2019
Chondroitin sulfate (CS) and chondroitin sulfate proteoglycan (CSPG) belong to the glycosaminoglycan (GAG) family, a class of poly-anionic glyco-conjugates widely expressed by animal cells. They play important roles in many biological events. Here, we summarize the main considerations in the design of chemical and enzymatic methodologies to access ...
Sherif Ramadan, Weizhun Yang, Xuefei Huang   +2 more
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Conjugation of chondroitin sulfates with amines

Russian Journal of Bioorganic Chemistry, 2008
Conjugation of chondroitin sulfates with pharmacologically important amines in a water medium in the presence of 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide was studied. Conjugates with amide and isoureidocarbonyl groups were synthesized.
I Iu, Ponedel'kina, V N, Odinokov, E S, Lukina, U M, Dzhemilev   +3 more
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Biosynthesis and function of chondroitin sulfate

Biochimica et Biophysica Acta (BBA) - General Subjects, 2013
Chondroitin sulfate proteoglycans (CSPGs) are principal pericellular and extracellular components that form regulatory milieu involving numerous biological and pathophysiological phenomena. Diverse functions of CSPGs can be mainly attributed to structural variability of their polysaccharide moieties, chondroitin sulfate glycosaminoglycans (CS-GAG ...
Tadahisa, Mikami, Hiroshi, Kitagawa
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Calcium binding by chondroitin sulfate

Calcified Tissue Research, 1968
The binding of calcium by chondroitin sulfate C was studied by employing biological and physicochemical methods for the quantitative determination of ionic calcium. Mean values for logKj, the logarithm of the uncorrected formation constant for a calcium-chondroitin sulfate complex, were 1.64 with the frog heart technique, 1.55 with the murexide method,
M R, Urist, D P, Speer, K J, Ibsen, B S, Strates   +3 more
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Biosynthesis of Chondroitin/Dermatan Sulfate

IUBMB Life, 2002
AbstractChondroitin sulfate and dermatan sulfate are synthesized as galactosaminoglycan polymers containing N ‐acetylgalactosmine alternating with glucuronic acid. The sugar residues are sulfated to varying degrees and positions depending upon the tissue sources and varying conditions of formation.
Jeremiah E, Silbert, Geetha, Sugumaran
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Chondroitin Sulfate in Osteoarthritis Therapy

Orthopedics, 2009
Despite the news of aid from chondroitin sulfate, recent research has questioned its efficacy in treating osteoarthritis.
Jonathan D, Morris, Kelly M, Smith
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Stability studies of chondroitin sulfate

Carbohydrate Research, 1999
The stability of chondroitin sulfate (CS) was studied under acidic, neutral and basic conditions at 30 and 60 degrees C. CS is remarkably stable under neutral conditions at low temperature, while it degrades at 60 degrees C producing low-molecular-mass fragments and desulfated products. This decomposition process begins at ca.
VOLPI, Nicola, MUCCI, Adele, SCHENETTI, Luisa   +2 more
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