Pronounced expression of extracellular matrix proteoglycans regulated by Wnt pathway underlies the parallel evolution of lip hypertrophy in East African cichlids. [PDF]
Machii N+8 more
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Recent Advances in Enzymes and Chemoenzymatic Synthesis of Tetrasaccharide Linkage Region of Proteoglycans. [PDF]
Lin PH, Huang X.
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B7-H3 and CSPG4 co-targeting as Pan-CAR-T cell treatment of triple-negative breast cancer. [PDF]
Stucchi S+12 more
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Chondroitin sulfate proteoglycans in neural development and regeneration
Proteoglycans are of two main types, chondroitin sulfate (CSPGs) and heparin sulfate (HSPGs). The CSPGs act mainly as barrier-forming molecules, whereas the HSPGs stabilise the interactions of receptors and ligands. During development CSPGs pattern cell migration, axon growth pathways and axon terminations.
CARULLI, Daniela+3 more
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Detection of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Melanoma
Methods in molecular biology, 2013The tumor antigen chondroitin sulfate proteoglycan 4 (CSPG4) appears to be a useful biomarker to identify melanoma cells and an attractive target to apply antibody-based immunotherapy for the treatment of melanoma. Here we described the reverse transcription-polymerase chain reaction (RT-PCR) method and the immunohistochemical (IHC) staining method to ...
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Stimulation of Chondroitin Sulfate Proteoglycan Production by Chondrocytes in Monolayer
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Functional and Clinical Relevance of Chondroitin Sulfate Proteoglycan 4
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Neurocan: a brain chondroitin sulfate proteoglycan
Cellular and Molecular Life Sciences, 2001Neurocan is a chondroitin sulfate proteoglycan of the lectican family and a component of the extracellular matrix of the central nervous system. It is mainly expressed during modeling and remodeling stages of this tissue. Neurocan can bind to various structural extracellular matrix components, such as hyaluronan, heparin, tenascin-C and tenascin-R, and
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Inhibition of Chondroitin Sulfate Proteoglycans by APRIL
2020Chondroitin sulfate proteoglycans (CSPGs) are major constituents of the extracellular matrix and well-established obstacles to regeneration in the central nervous system. As such, they are promising targets for therapy in neurological pathologies where repair is needed, such as spinal cord injuries, and multiple sclerosis.
Bertrand Huard, Mashal Claude Ahmed
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