Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism
Cell Proliferation, EarlyView.Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang +11 more
wiley +1 more source
Advancing ultrafast (S)TEM with the combination of an RF cavity and an electrostatic beam blanker. [PDF]
Struct DynBongiovanni G +3 more
europepmc +1 more source
CKAP4 Regulates ERS‐Induced Apoptosis in Osteoclasts Through FOXO3 in Periodontitis
Cell Proliferation, EarlyView.CKAP4 promotes the transcription of PERK via FOXO3 in OCs, thereby facilitating ER stress‐induced apoptosis. In periodontitis, the reduction of CKAP4 in OCs leads to decreased OC apoptosis, which exacerbates alveolar bone resorption. ABSTRACT Periodontitis is a prevalent oral disease characterised by chronic inflammation and irreversible alveolar bone ...
Jiayu Cheng +12 more
wiley +1 more source
CMOS-Compatible ZrO<sub>2</sub>-Based Film for Photoplethysmography Sensors Enabling Accurate and Sensitive Health Monitoring. [PDF]
ACS Appl Mater InterfacesEstrócio N +13 more
europepmc +1 more source
Cell Proliferation, EarlyView.This study presents an NDs‐mediated localised combination strategy that integrates autophagy inhibition with low‐dose ATO sensitization, enabling effective tumour suppression while enhancing safety. NDs‐mediated autophagy blockade enhances ATO efficacy while minimising systemic toxicity, highlighting a promising approach for solid tumour treatment ...
Yiliu Wang +8 more
wiley +1 more source
Intrinsic Negative Magnetoresistance and Broadband Photoresponse in Magnetic van der Waals Crystal TaFeTe<sub>2</sub>. [PDF]
Adv Sci (Weinh)Li C +7 more
europepmc +1 more source
Cell Proliferation, EarlyView.Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao +7 more
wiley +1 more source
Broadband Fourier-Transform Optical Photothermal Infrared Spectroscopy and Imaging. [PDF]
Anal ChemRazumtcev A +6 more
europepmc +1 more source
Rare Secondary Neoplasms Arising in Epidermal Nevus: A Case Series and Literature Review
Journal of Cutaneous Pathology, EarlyView.ABSTRACT Malignant transformation is known to occur with many nevi, such as nevus sebaceus. However, cases of secondary tumors developing in an epidermal nevus (EN) are rare, with only a few case reports documented in the literature. We present three unique cases of syringocystadenoma papilliferum (SCAP), syringofibroadenoma, trichilemmoma, and basal ...
Haya A. Homsi +5 more
wiley +1 more source
Neuroimmune alterations and nociceptive behavior in oral carcinogenesis in rats
European Journal of Oral Sciences, EarlyView.Abstract Oral cancer pain is a frequent and debilitating symptom associated with tumor progression. Although neuronal mechanisms have been extensively studied, the role of immune and glial cells in the trigeminal nociceptive pathway remains poorly understood.
Joana Maria dos Santos Alves +7 more
wiley +1 more source