Results 51 to 60 of about 299,019 (288)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

A Dynamic Instrumentation Amplifier for Low-Power and Low-Noise Biopotential Acquisition

Sensors, 2016
A low-power and low-noise dynamic instrumentation amplifier (IA) for biopotential acquisition is presented. A dynamic IA that can reduce power consumption with a timely piecewise power-gating method, and noise level with an alternating input and chopper ...
Jongpal Kim, Hyoungho Ko
doaj   +1 more source

Compound Heterozygote Friedreich Ataxia Patients With Covert Proximal FXN Gene Deletions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We present Friedreich ataxia patients with frataxin gene deletions. Data and records were collected at the Children's Hospital of Philadelphia from patients enrolled in the FACOMS natural history study. Patients with proximal deletions initially diagnosed with only one GAA expanded allele had more severe disease than their homozygous expansion
Michael P. Lazaropoulos, Morgan C. Devore, Christina Lam, Courtney Park, Sanjay Bidichandani, David R. Lynch   +5 more
wiley   +1 more source

Tailored Diketopyrrolopyrrole Derivatives for Efficient Deep‐Red Organic Lasers

Advanced Functional Materials, EarlyView.
Tailored diketopyrrolopyrrole derivatives exhibit high stable amplified spontaneous emission with single or dual bands. Incorporated into distributed‐feedback lasers based on one‐ and two‐dimensional dichromated‐gelatin diffractive gratings, these materials provide a robust, flexible platform for integrated organic deep‐red light sources. ABSTRACT Deep‐
Pablo Pasqués‐Gramage, Abelardo Sánchez‐Oliva, Álex Farrando‐Pérez, Pedro G. Boj, M. Victoria Gómez, Ana M. Rodríguez, Pilar Prieto, Rafael Muñoz‐Mármol, Andrew J. Musser, Iván Torres‐Moya, María A. Díaz‐García   +10 more
wiley   +1 more source

High‐Speed Photoresponse of CVD‐Grown Lateral TMD Heterostructures

Advanced Functional Materials, EarlyView.
Internal electric fields generated by p‐n junctions and asymmetric Schottky barriers enhance the photoresponse speed in CVD‐grown monolayer TMD lateral heterostructures. This results in a 1.5‐2 orders of magnitude reduction in rise and fall times for optimized device configurations compared to homogeneous single‐material devices, enabling bandwidths ...
Mario Martin, Axel Printschler, William Roberts, Jonas L. Hiller, Patrick Michel, Martin Eberle, Marco Hammer, Md Tarik Hossain, Andrey Turchanin, Marcus Scheele   +9 more
wiley   +1 more source

Zero Drift Infrared Radiation Thermometer Using Chopper Stabilised Pre-Amplifier

Applied Sciences, 2020
A zero-drift, mid–wave infrared (MWIR) thermometer constructed using a chopper stabilised operational amplifier (op-amp) was compared against an identical thermometer that utilised a precision op-amp.
Andrew D. Heeley, Matthew J. Hobbs, Jon R. Willmott   +2 more
doaj   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Low-Noise, Low-Power Readout IC for Two-Electrode ECG Recording Using Common-Mode Charge Pump for Robust 20-V_PP Common-Mode Interference

Applied Sciences, 2022
A low-noise and -power readout integrated circuit (IC) for two-electrode electrocardiogram (ECG) recording is developed in this study using a common-mode charge pump (CMCP) for a robust 20-VPP common-mode interference (CMI).
Kyeongsik Nam, Gyuri Choi, Mookyoung Yoo, Sanggyun Kang, Byeongkwan Jin, Hyeoktae Son, Kyounghwan Kim, Hyoungho Ko   +7 more
doaj   +1 more source

Dynamic Mechanical Loading Modulates Extracellular Vesicle Production and Cargo in Meniscus Fibrochondrocytes

Advanced Materials Interfaces, EarlyView.
Dynamic mechanical loading of outer meniscus fibrochondrocytes increases extracellular vesicle (EV) yield and alters EV composition. When applied to progenitor cells, these mechanically primed EVs modulate the expression of matrix‐related genes.
Catherine Cheung, Zizhao Li, Sung‐Han Jo, Se‐Hwan Lee, Il Keun Kwon, Jina Ko, Su Chin Heo   +6 more
wiley   +1 more source

Design of sigma-delta modulator 10-16 bits for resolver digital converter

Dianzi Jishu Yingyong, 2022
In this paper, a sigma-delta modulator for 10-16 bit resolver digital converter is designed. The modulator is a second-order structure. On this basis, a chopper modulator circuit is added to eliminate the flicker noise.
Gu Jun, Zhang Guohua, Zhu Xiaoyu
doaj   +1 more source