Results 151 to 160 of about 3,158 (253)

Therapeutic potential of a Bax inhibitor‐1/TMBIM6 antagonist (BIA) and its analogues in Aspergillus fumigatus‐induced asthma via dual targeting of AKT and epithelial‐derived inflammatory cytokines

British Journal of Pharmacology, EarlyView.
Background and Purpose Aspergillus fumigatus (A. fumigatus) exposure causes of severe allergic asthma, characterized by airway inflammation and epithelial dysfunction. TMBIM6 (Bax inhibitor‐1) has been implicated in airway epithelial stress responses and AKT signalling.
Young‐Jin Yu, Ahsan Ullah, Jisun Kim, Mehedi Hasan Bappi, Yerim Heo, Jin Hee Ahn, Hyun‐Kyoung Kim, Han‐Jung Chae   +7 more
wiley   +1 more source

Integrated transmission-reflection strong-field terahertz time-domain spectroscopy. [PDF]

iScience
Li J, Xu A, Kong D, Cai J, Qu W, Zhang Z, Zhang M, Liu Y, Yang Y, Weng S, Wu X.   +10 more
europepmc   +1 more source

Techniques of Reducing Switching Artifacts in Chopper Amplifiers

IEICE Transactions on Electronics, 2020
openaire   +2 more sources

Hypericin Suppresses Liver Cancer Through Autophagic Degradation of AKT and Eliciting Antitumor Immune Response

Cancer Science, EarlyView.
Hypericin induces autophagic AKT degradation by promoting AKT‐HSPA5 interaction in an S473 phosphorylation‐dependent manner, suppressing HCC growth. It enhances CD8+ T cell‐mediated antitumor immunity and synergizes with anti‐PD‐L1 therapy, showing favorable safety for HCC treatment. ABSTRACT Hepatocellular carcinoma (HCC) is the most prevalent primary
Sien Ma, Qianqian Xu, Mengjuan Zhu, Xianming Ge, Jian Xu, Yan Pan, Mengli Wang, Yuting Zhu, Aoxuan Xu, Hanmeng Liu, GuangHai Xiang, Weipeng Gong, Bao Zhao   +12 more
wiley   +1 more source

Exploring Culturally Safe Oral Health Services for a Regional Aboriginal Community in Victoria

Community Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT Objectives National policies have been introduced to promote the delivery of Culturally Safe dental care for Aboriginal and Torres Strait Islander Australians. However, the understanding of what constitutes Culturally Safe dental care and how it can be effectively implemented into clinical practice, remains limited.
Eliza Collins, Shawana Andrews, Julie Satur   +2 more
wiley   +1 more source

Two-Photon Sub-Bandgap Photocurrent in Surface-Nanotextured Black Diamond Films for Solar Energy Conversion. [PDF]

ACS Photonics
Girolami M, Bellucci A, Mastellone M, Orlando S, Pettinato S, Serpente V, Salvatori S, Trucchi DM.   +7 more
europepmc   +1 more source

Listening to Children's Need to Matter in Skipped Generation Migrant Households: A Study in Rural Hunan, China

Child &Family Social Work, EarlyView.
ABSTRACT This article explores the experiences of children who live in skipped generation households because of parental migration. Drawing on our matched interviews with 34 children and 20 grandparents from 19 skipped generation households in rural Hunan, central China, we examine what the children wanted significant adults to know about their care ...
Rachel Murphy, Li Mi, Xiaoyan Huang
wiley   +1 more source

Advancing ultrafast (S)TEM with the combination of an RF cavity and an electrostatic beam blanker. [PDF]

Struct Dyn
Bongiovanni G, van Rijt MMJ, Sháněl O, Kieft ER.   +3 more
europepmc   +1 more source

Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism

Cell Proliferation, EarlyView.
Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang, Yuan‐Tao Qiu, Jing‐Yue Cao, Yi‐Feng Huang, Ye‐Lin Lan, Yu‐Li Zhao, Fu Wu, Chen‐Long Wang, Guo‐Run Tang, Jing‐Yun Ji, Zhang Zhang, Guan‐Zheng Luo   +11 more
wiley   +1 more source

CKAP4 Regulates ERS‐Induced Apoptosis in Osteoclasts Through FOXO3 in Periodontitis

Cell Proliferation, EarlyView.
CKAP4 promotes the transcription of PERK via FOXO3 in OCs, thereby facilitating ER stress‐induced apoptosis. In periodontitis, the reduction of CKAP4 in OCs leads to decreased OC apoptosis, which exacerbates alveolar bone resorption. ABSTRACT Periodontitis is a prevalent oral disease characterised by chronic inflammation and irreversible alveolar bone ...
Jiayu Cheng, Dihao Tao, Wenzhe Wang, Huiyu Wang, Hanzhe Wang, Yufan Liang, Jia Guo, Wenhao Liu, Yiming Wang, Jianhua Yang, Xiaoning He, Ce Shan, Bei Li   +12 more
wiley   +1 more source