Results 221 to 230 of about 16,972 (295)

Unconventional bipartite entanglement in the quantum dimer magnet Yb₂Be₂SiO₇. [PDF]

Nat Commun
Brassington A, Ma Q, Duan G, Calder S, Kolesnikov AI, Taddei KM, Sala G, Choi ES, Wang H, Xie W, Frandsen BA, Li N, Sun XF, Liu C, Yu R, Zhou HD, Aczel AA.   +16 more
europepmc   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Development of Time-Resolved Luminescence Measurement Instruments for Biosensing and Bioimaging - An Overview. [PDF]

Measurement (Lond)
Sreenan B, Kafil V, Wells D, Kharal G, Hunt T, Gulbag A, Park J, Xu H, Sanad M, Fadali MS, Jia Y, Cheng Q, AuCoin D, Miller LW, Zhu X.   +14 more
europepmc   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

Single-pixel infrared imaging thermometry maps human inner canthi temperature. [PDF]

Nat Commun
Jiang C, Kilcullen P, Lai Y, Ozaki T, Liang J.   +4 more
europepmc   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Photothermal effects control ultrafast charge transport in titanium carbide MXenes. [PDF]

Nat Commun
Zheng W, Ramsden H, Ippolito S, van Hemert M, Zhang D, Zhang T, Li D, Wen G, Geuchies JJ, Yu M, Feng X, Gogotsi Y, Tielrooij KJ, Wang HI.   +13 more
europepmc   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Design and Implementation of a Low-Power Biopotential Amplifier in 28 nm CMOS Technology with a Compact Die-Area of 2500 μm² and an Ultra-High Input Impedance. [PDF]

Sensors (Basel)
Ranjbar Koleibi E, Lemaire W, Koua K, Benhouria M, Bostani R, Serri Mazandarani M, Gauthier LP, Besrour M, Ménard J, Majdoub M, Gosselin B, Roy S, Fontaine R.   +12 more
europepmc   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source