Results 211 to 220 of about 123,487 (278)

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

Van der Waals/MCT heterostructure enabled high-performance uncooled mid-infrared photodetectors via synergistic suppression of dark current and interfacial recombination. [PDF]

Light Sci Appl
Zhang X, Zhou T, Cui Y, Li R, Wu H, Zhang Y, Lin R, Yang F, Liu K, Wu J, Wan D, Zhang J, Lu J, Ni Z.   +13 more
europepmc   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Broadband Fourier-Transform Optical Photothermal Infrared Spectroscopy and Imaging. [PDF]

Anal Chem
Razumtcev A, Turner GA, Zayats S, Borondics F, Polyzos A, Simpson GJ, Bechtel HA.   +6 more
europepmc   +1 more source

Fatigue of AM TiAl6V4: Probabilistic Modelling of the Size Influence as a Transfer Method From Test Specimen to Part

Fatigue &Fracture of Engineering Materials &Structures, EarlyView.
ABSTRACT This paper investigates the fatigue behavior of additively manufactured TiAl6V4 by comparing two specimen geometries with different highly stressed volumes. A fracture mechanical approach based on the El‐Haddad–Smith–Topper model is combined with defect analysis through X‐ray computed tomography.
Sebastian Mansky, Dirk Herzog, Ingomar Kelbassa   +2 more
wiley   +1 more source

Intrinsic Negative Magnetoresistance and Broadband Photoresponse in Magnetic van der Waals Crystal TaFeTe₂. [PDF]

Adv Sci (Weinh)
Li C, Wu J, Lu S, Liang L, Zhou W, Zhang B, Zhao D, Liu F.   +7 more
europepmc   +1 more source

Poorly differentiated lung adenocarcinomas with concurrent ALK and CD30 expression: a diagnostic pitfall mimicking ALK‐positive anaplastic large‐cell lymphoma

Histopathology, EarlyView.
Poorly differentiated lung adenocarcinomas with concurrent anaplastic lymphoma kinase (ALK) and CD30 expression closely mimic ALK‐positive anaplastic large‐cell lymphoma, creating a significant diagnostic pitfall. Accurate classification requires comprehensive integration of clinical, radiologic, morphologic, immunophenotypic and molecular findings ...
Jietian Jin, Wenjian Cen, Qin Yan, Yangshan Chen, Chaoyun Huang, Yanfeng Feng, Neng Jiang   +6 more
wiley   +1 more source

Early‐life pathways to inequalities in child mental health: evidence from eight birth cohorts

Journal of Child Psychology and Psychiatry, EarlyView.
Background Socioeconomic inequalities in children's emotional and behavioural problems are already present at school entry. We examined associations between early‐life socioeconomic conditions and children's externalising and internalising problems and assessed whether early‐life risk factors mediated these associations.
Demetris Avraam, Gabriella Melis, Tim Cadman, Jennie Carson, Marie Aline Charles, Yu Wei Chua, Ahmed Elhakeem, Joaquín Escribano, Veit Grote, Dariusz Gruszfeld, Kathrin Guerlich, Rae‐Chi Huang, Jennifer R. Harris, Jesus Ibarluzea, Jordi Julvez, Berthold Koletzko, Ashleigh Lin, Unai Martin, Rosemary McEachan, Maria Melchior, Phillip Melton, Johanna Thorbjornsrud Nader, Angela Pinot de Moira, Maja Popovic, Simona Porru, Lorenzo Richiardi, Blanca Sarzo, Daniela Schlüter, Jordi Sunyer, Morris Swertz, Elvira Verduci, John Wright, Annick Xhonneux, Tiffany Yang, Daniela Zugna, Anne‐Marie Nybo Andersen, Katrine Strandberg‐Larsen, David Taylor‐Robinson   +37 more
wiley   +1 more source

Ultrafast Electrical Charge Injection in Operating Perovskite Light-Emitting Diodes by Infrared Optical Control

Bakulin A, Gao R, Yuan Z, Yang B, Li L, Houot M, Huang M, Spencer B, Park S, Gasparini N, Snaith H, Chen Z.   +11 more
europepmc   +1 more source

Suppressed excitonic effects enable high mobility and high-yield photoconductivity in a pyridine-coordinated two-dimensional polymer crystal. [PDF]

Nat Commun
Fu S, Yang Y, Gao G, Zhao S, Položij M, Zhu T, Gao L, Heine T, Wang Z, Bonn M, Feng X.   +10 more
europepmc   +1 more source