Results 71 to 80 of about 3,714 (283)

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, EarlyView.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source

Reconfigurable Sensor Analog Front-End Using Low-Noise Chopper-Stabilized Delta-Sigma Capacitance-to-Digital Converter

Micromachines, 2018
This paper proposes a reconfigurable sensor analog front-end using low-noise chopper-stabilized delta-sigma capacitance-to-digital converter (CDC) for capacitive microsensors.
Hyungseup Kim, Byeoncheol Lee, Yeongjin Mun, Jaesung Kim, Kwonsang Han, Youngtaek Roh, Dongkyu Song, Seounghoon Huh, Hyoungho Ko   +8 more
doaj   +1 more source

Dipole‐Manipulated Built‐In Electric Field Enables Ultrafast Charge Separation in Perylene Diimide Polymers for Photoelectrochemical Water Splitting

Advanced Science, EarlyView.
Molecular dipole engineering in dendritic perylene diimide polymers through nitrogen‐rich heterocyclic linkers amplifies the built‐in electric field, enabling sub‐picosecond charge separation and efficient multi‐electron accumulation. This structure–dynamics–performance relationship establishes a versatile design strategy for high‐performance organic ...
Ying‐Xin Qiao, Zicong Situ, Yi‐Jing Chen, Shuo‐Xiang Liu, Jing‐Lan Zhang, Xingqing Li, Luo‐Han Xie, Si‐Hang Xie, Qing‐Xiao Tong, Andong Xia, Zhuoran Kuang, Jing‐Xin Jian   +11 more
wiley   +1 more source

Amplification of Endoplasmic Reticulum Stress via Inhibiting Lipid Droplet Formation to Enhance Chemodynamic Immunotherapy

Advanced Science, EarlyView.
An endoplasmic reticulum (ER)‐targeted chemodynamic nanoagent (TCBQ/iLD‐ER NPs) comprising •OH‐generating tetrachloro‐1,4‐benzoquinone (TCBQ) and lipid droplets (LDs) formation inhibitor (iLD) is developed for chemodynamic immunotherapy of tumors. After ingestion by cancer cells, TCBQ/iLD‐ER NPs preferentially accumulate in the ER and react with ER ...
Huilan Cai, Shaoru Zhuang, Yang Zhu, Rujiang Ao, Meili Yu, Tingting Cui, Jun Wang, Xuegang Niu, Hongwei Huang, Shanshan Peng, Yu He, Lisen Lin, Huanghao Yang   +12 more
wiley   +1 more source

Ultrafast Dynamics of Spin Current and Electron Temperature in Spintronic Terahertz Emitters

Advanced Science, EarlyView.
This work quantifies optical‐pump‐induced THz transmission variations to reveal electron and lattice temperature dynamics and presents time‐resolved THz spectral maps for sub‐picosecond analysis. A 63 ± 8 fs time lag between THz emission and laser excitation is identified, serving as an intrinsic parameter limiting the upper frequency of spintronic THz
Yifan Wang, Zuanming Jin, Miao Cai, Zhiqiang Lan, Zhenjie Ge, Zheng Feng, Wei Tan, Alexei V. Balakin, Alexander P. Shkurinov, Yan Peng, Yiming Zhu   +10 more
wiley   +1 more source

A Low-Input Current Chopper Amplifier

, 2012
This thesis describes the implementation of a low input-current chopper amplifier. Chopper amplifiers are attractive in applications where high DC precision is required, due to their low offset, drift & 1/f noise.
Chava, B.C. (author)
core  

Low-voltage DDA-based chopper-stabilized amplifier for biosignal processing

, 2023
This dissertation presents a low-voltage chopper-stabilized Differential Difference Amplifier (DDA) instrumentation amplifier. The proposed DDA incorporates feed-forward frequency compensation and a Type II compensator to achieve good bandwidth and phase
Fan, Xinlan
core  

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

A 55 V, 6.6 nV/√Hz Chopper Operational Amplifier with Dual Auto-Zero and Common-Mode Voltage Tracking

Eng
For high-voltage signal detection applications, an auto-zero and chopper operational amplifier (OPA) is proposed in this paper. With the auto-zero and chopper technique, the OPA adopts an eight-channel Ping-Pong mechanism to reduce the high-frequency ...
Zhifeng Chen, Yuyan Zhang, Yaguang Yang, Chengying Chen   +3 more
doaj   +1 more source

Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing

Advanced Science, EarlyView.
We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Linsha Ma, Pengcheng Yao, Shengqi Wu, Yuanyuan Shi, Lang Qin, Baitao Li, Jiayi Zhu, Minhua Huang, Yichong Zhu, Yuwen Song, Jinhuan Pang, Ziping Guo, Guochuan Wu, Chen Wang, Kewei Xu, Ruihua Huang, Quan Kuang, Liang Qu, Changtian Pan, Xianrong Xie, Qinlong Zhu, Jiaying Huang, Qiupeng Lin   +22 more
wiley   +1 more source