Results 41 to 50 of about 3,714 (283)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Compound Heterozygote Friedreich Ataxia Patients With Covert Proximal FXN Gene Deletions
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT We present Friedreich ataxia patients with frataxin gene deletions. Data and records were collected at the Children's Hospital of Philadelphia from patients enrolled in the FACOMS natural history study. Patients with proximal deletions initially diagnosed with only one GAA expanded allele had more severe disease than their homozygous expansion
Michael P. Lazaropoulos +5 more
wiley +1 more source
A Dynamic Instrumentation Amplifier for Low-Power and Low-Noise Biopotential Acquisition
Sensors, 2016 A low-power and low-noise dynamic instrumentation amplifier (IA) for biopotential acquisition is presented. A dynamic IA that can reduce power consumption with a timely piecewise power-gating method, and noise level with an alternating input and chopper ...
Jongpal Kim, Hyoungho Ko
doaj +1 more source
Advanced Engineering Materials, EarlyView.Additive manufacturing provides precise control over the placement of continuous fibres within polymer matrices, enabling customised mechanical performance in composite components. This article explores processing strategies, mechanical testing, and modelling approaches for additive manufactured continuous fibre‐reinforced composites.
Cherian Thomas, Amir Hosein Sakhaei
wiley +1 more source
Advanced Functional Materials, EarlyView.Bandgap‐engineered AlGaAs/GaAs heterostructures exhibit wavelength‐selective dual‐polarity photoelectrochemistry, switching from photocathodic to photoanodic response depending on excitation wavelength. The polarity transition is governed by band‐selective absorption, built‐in electric‐field‐driven carrier transport, and interfacial charge‐transfer ...
Yukai Mao +9 more
wiley +1 more source
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
Advanced Functional Materials, EarlyView.All‐solution‐processed, low‐cost extended short‐wavelength infrared photodetectors are realized by coupling colloidal HgTe quantum dots to plasmonic In2O3:Sn,F nanocrystals. Localized surface plasmon resonances boost and spectrally tailor light absorption between 1500 and 3000 nm, enabling responsivities above 40 A W−1.
Kseniia A. Sergeeva +9 more
wiley +1 more source
Second‐Harmonic Hyper‐Mie Optical Activity Enables Closed‐Loop Chiral Photochemistry
Advanced Materials, EarlyView.Nonlinear chiral photochemistry is demonstrated in CdTe/CdO nanohelices, where circularly polarized infrared light both drives and tracks photo‐oxidation via second‐harmonic scattering. This closed‐loop process reveals real‐time structural evolution, including shell fracturing and core exposure, accompanied by a transition from hyper‐Mie to hyper ...
Hoyeon Choi +6 more
wiley +1 more source
Applied Sciences, 2022 A low-noise and -power readout integrated circuit (IC) for two-electrode electrocardiogram (ECG) recording is developed in this study using a common-mode charge pump (CMCP) for a robust 20-VPP common-mode interference (CMI).
Kyeongsik Nam +7 more
doaj +1 more source